Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 42 for “"vascular development"”.
-
Pericytes in Early Vascular Development
… between endothelial cells and pericytes during development, we observed vascular morphology in three and four dimensions, as well as the genetic and molecular mechanisms underlying how these cells are recruited and interact in several experimental models. Thus, to thoroughly analyze the …
-
The use of small molecules to illuminate vascular development
Development of the vascular system is a multifactorial process. Its proper establishment has a big impact on life. Not only is this process essential for organismal growth but abnormal blood vessel formation leads to several pathologies. In some cases the disease itself triggers changes to the …
-
Fibronectin splice isoforms in wound healing and vascular development
… are present at high levels during embryonic development. In adult animals, these isoforms are expressed around the perimeter of blood vessels and are induced in response to injury. We have developed an in vitro system using a set of bacterially expressed fibronectins and fibronectin-null …
-
The Role of Semaphorin-Neuropilin-1 Signalling in Pulmonary Vascular Development
… evidence suggests that normal pulmonary vascular morphogenesis is critical for the formation and maintenance of the lung parenchyma, both pre- and postnatally. Indeed, the disruption of angiogenic pathways, whether through inherent genetic predisposition or as a consequence of life-saving …
-
Mesothelial and Mural Cell Contribution to Vascular Development through PDGF Signaling
Vascular development during embryogenesis and adulthood occurs through vasculogenesis and angiogenesis. Vasculogenesis is the de novo formation of blood vessels from mesoderm precursor cells. Angiogenesis is the formation of new vessels from existing vessels. Both processes involve hematopoietic, …
-
Extracellular Matrix Contributions to Early Vascular Development and Pericyte Precursor Dynamics
… from the body. The formation of a functioning vascular system depends on the close coordination of many cell types and, on the capillary level, specifically endothelial cells and pericytes as well as the surrounding protein microenvironment, known as the extracellular matrix (ECM). Impaired …
-
Modeling the Heterogeneous Brain Tumor Microenvironment to Analyze Mechanisms of Vascular Development and Chemoresistance
… factors could contribute to tumor initiation, development, and therapeutic resistance. Analyzing how the microenvironment drives tumor development and cancer cell heterogeneity is particularly important in cancers such as glioblastoma multiforme (GBM) that have no known risk factors and are …
-
A sorghum NAC gene is associated with variation in vascular development, biomass properties, and yield potential
… the rigidity and strength of the stalk. Vascular architecture influences not only stalk strength and rigidity, but also water, nutrient and sugar transport, which ultimately determine grain yield. The building blocks of the vascular system are secondary cell walls, which make up the …
-
Histone Deacetylase 7 and Transcriptional Regulatory Networks of the Vascular Endothelium
… their expression patterns, and each have unique developmental and physiological functions. The studies described here focus on HDAC7, a class II HDAC that is expressed in vascular endothelial cells and whose function is essential for the maintenance of vascular integrity during embryogenesis. …
-
Development Of Trophoblast Lined Blood Spaces In The Mouse Placenta
… (TGCs) have a unique ability to form pseudo-vascular spaces in the placenta. Proper development of these maternal blood spaces is crucial for successful pregnancy outcomes. Unlike blood vessels in other organs, the vascular space in placenta is line by non-endothelial TGCs. Previous work in …
-
Nkx3.2 regulates zebrafish vascular stabilization through recruitment of mural cells
Vascular stabilization is the process during vascular development where the immature endothelial cell tube gains structural support through the recruitment and adhesion of perivascular mural cells; pericytes and vascular smooth muscle cells (vSMC). When vessels are not well supported by mural cells …
-
Pericyte deficiencies in a foxf2 loss of function mutant
Pericytes are critical players in vascular development and disease but are not widely studied in the context of cerebral small vessel disease, a vascular condition related to stroke that progressively weakens brain microvessels. Foxf2, a pericyte-expressed gene, is involved in vascular stability …
-
Origins and Development of the Embryonic Vascular System in Xenopus
Each step of vascular development needs to be carefully regulated; endothelial precursors must be specified, these cells then proliferate and coalesce to form vascular cords, and finally they lumenate, undergo angiogenic branching and remodeling, and recruit smooth muscle cells to establish a …
-
Nanoparticle toxicity and molecular mechanisms in fish: A case study with silver nanoparticles
… effects and mechanisms of metal-based NPs on the vascular system. <em>In vitro</em> studies have shown that NPs are anti-angiogenic because they cause inflammation, oxidative stress, and apoptosis of endothelial cells resulting in increased permeability and decreased proliferation and migration. …
-
Notch deficiency leads to arteriovenous malformations and altered pericyte function
… membrane with the endothelium to provide vascular support. Pericytes are a critical component of the blood-brain barrier and regulate endothelial cell proliferation, vessel diameter, and vascular permeability. Endothelial cells express Notch1, whereas pericytes express both Notch1 and …
-
Notch Regulates Vascular Collagen IV Basement Membrane Through Modulation of Lysyl Hydroxylase 3 Trafficking
… essential for blood vessel stability. Defects in vascular Col IV deposition are the basis of heritable disorders, such as small vessel disease, marked by cerebral hemorrhage and drastically shorten lifespan. To date, little is known about how endothelial cells regulate the intracellular transport …
-
Impacts of Placental Growth Factor Deficiency and of Preeclampsia on Brain Development and Function
… PE, and brain structural and functional development in PE-F1s. It was hypothesized that PGF deficiency, which often manifests in PE, diminishes brain vascular development, leading to impaired cognition and elevated stroke risk postpartum. Uteroplacental angiogenesis was assessed in …
-
Regulation of Blood Vessel Development via Rho Family GTPase Signaling
… proteins and their regulators regulate mammalian vascular morphogenesis and maintenance. First we assessed the role of the Rho GTPase Cdc42 during vasculogenesis and angiogenesis. We find that Cdc42 is essential for organization of EC adhesion, as its loss results in disorganized cell-cell …
-
The Role of Angiopoietin-2 in Signaling Through the Endothelial Receptor Tyrosine Kinase Tie1
… a host of physiologic and pathologic processes. Vascular development and maintenance are tightly regulated by a number of signaling processes, among which the Tie proteins are two functioning receptors. Although they have been shown to exhibit essential roles in endothelial cell sprouting and …
Page 1 of 3