Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"vascular dementia"”.
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Risk Factors for Vascular Dementia
Dementia is a devastating disorder that commonly affects people over the age of 65. Alzheimer's disease and vascular dementia are the most common forms of dementias. A number of studies have implicated cardiovascular risks as important factors in the development of dementia. These risks include …
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Observations on cerebral amyloid angiopathy and microvascular pathology in Alzheimer's disease and vascular dementia
Dementia is a state of permanent loss of cognitive function, most commonly affecting the elderly. With a rapidly growing aged population, the spectrum of disorders that lead to dementia is exerting an ever-increasing toll on patients, families and society alike. The most common dementing disorders …
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Investigating the interrelated roles of pain and cultural factors on cognitive task performance among patients living with vascular dementia
… cognitive task performance in individuals with Vascular Dementia. Vascular Dementia, a common form of dementia resulting from reduced blood flow to the brain, is characterised by cognitive impairments, executive function deficits, and behavioural and psychological symptoms. Chronic pain, a …
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HISTAMINERGIC H3 AND CANNABINOID CB1 RECEPTORS IN DEMENTIA
… status of H3 receptors remain unchanged under vascular dementia or mixed dementia pathology, and may serve as a therapeutic target for cognitive deficits. Measurements of CB1 receptors in postmortem brain samples of Lewy body dementia patients indicate the possible relationship between CB1 loss …
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Disruptive behaviour in nursing home residents: A study of some predisposing factors
… in two primary diagnostic categories; those with vascular dementia and those with dementia due to other causes, primarily Alzheimer's disease. A review of the literature suggested that the nature and frequency of disruptive behaviour differed across these two prevalent forms of dementia. The level …
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Dementia with Lewy bodies —an Investigation of Cause and Consequence
Dementia with Lewy bodies (DLB) is today considered to be the second most common primary neurodegenerative dementia after Alzheimer’s disease. However, the disease has only been a clearly defined entity for 13 years. Due to its recent recognition, DLB is still not as extensively studied as are …
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Neuropathological findings and staging in dementia
Dementia is a clinical syndrome with the development of impairment in multiple cognitive functions (including memory), severe enough to interfere with activities of daily living, as the main symptom. There are a large number of disorders that can lead to dementia, and neuropathological examination …
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Unravelling the Genetics of Cerebral Small Vessel Disease
… disease (CSVD) is a major cause of stroke and vascular dementia. While CSVD is mostly sporadic (caused by a complex mix of environmental and genetic risk factors), its rare monogenic forms have been increasingly identified. The most common of these, cerebral autosomal dominant arteriopathy with …
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Memory appraisals by older people : associated factors and spousal relationship quality
… of memory function in older people without dementia. Recent research suggests that subjective memory complaints may precede objective cognitive decline in older people, but whilst several factors have been associated with increased complaints, the pattern of factors associated with actual …
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The Relationship of Inflammatory Markers to Cognitive Function in a Population-Based Sample
… to play critical roles in atherosclerosis and vascular disease, and have been linked to Alzheimer’s Disease, vascular dementia, and subclinical levels of cognitive decline. The present study investigated the relationship of these four inflammatory markers to cognitive function prospectively, …
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Blood-Brain Barrier Permeability and Inflammation in Cerebral Small Vessel Disease
… third of strokes and is the most common cause of vascular dementia. It is characterised by white matter lesions and more diffuse damage outside of the lesions. Despite its importance, the mechanisms causing white matter damage are incompletely understood. Both increased blood-brain barrier (BBB) …
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An evaluative investigation of the effects of establishing a personalized system of prosthetic aids to memory for dementing persons in the home environment
… for individuals with mild to moderate dementia. The system of aids developed were in the form of a free-standing "Memory Center" unit. Caregivers were responsible for actively training their relatives to use the aids to compensate for deficits in orientation and memory for information …
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Potential Risk Factors Indicating the Likelihood of Aggression and Violence in Individuals with Dementia: a Systematic Review
BACKGROUND: Aggression in individuals with dementia is a common behavioural symptom of the disorder, and has been found to be the most reported source of caregiver distress, and the main reason why an individual will be placed in residential care.<br/>OBJECTIVES: To establish the factors which can …
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Genetics of Cerebral Small Vessel Disease
… disease (SVD) is a leading cause of stroke and vascular dementia. The majority of cases are sporadic, occurring in the elderly hypertensive population. However, there also exist patients with familial disease. The most common form is Cerebral Autosomal Dominant Arteriopathy with Subcortical …
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Fatigue in Cerebral Small Vessel Disease and its Relationship to Cognitive Behavioural Symptoms
… brain. SVD is a leading cause of both stroke and vascular dementia, whilst cognitive behavioural symptoms such as fatigue are also frequent. Fatigue has a major impact on quality of life, yet little is known about its pathogenesis. This thesis aimed to assess the prevalence of, and possible …
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Mechanisms of vascular cognitive impairment in cerebral small vessel disease and stroke
… brain and is a major contributor to stroke and vascular cognitive impairment (VCI). Although VCI poses a significant public health burden, the underlying biological processes and mechanisms remain poorly understood. The pursuit of this avenue of research has uncovered several mechanisms of …
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Predictors of Response to Acetylcholinesterase Inhibitors: An Observational Case Register-Based Cohort Study
… inhibitors (AChEIs) are a key component of dementia care. Longitudinal cognitive change in patients before and after AChEI initiation has never been described previously, although individual responses have been described as heterogeneous. Predictors of such responses are not well …
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Cardiovascular magnetic resonance characterisation of the phenotype of resistant uncontrolled hypertension
… with RH are significantly predisposed to cardiovascular (CV) diseases compared to patients with controlled BP. Consequences of RH include left ventricular hypertrophy, heart failure, ischaemic heart disease, chronic kidney disease leading to end-stage renal disease, stroke, vascular dementia, CV …
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Vascular contributors to cognitive impairment and dementia: insights from existing data
Cognitive impairment and dementia pose a significant and growing public health challenge, yet progress in developing effective interventions to prevent dementia or slow cognitive decline has been limited. Among potential targets, vascular risk factors have emerged as particularly promising. Given …
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