Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"vascular complications"”.
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Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha
Vascular complications of diabetes account for the majority of morbidity and mortality among diabetic patients. Large clinical trials have identified hyperglycemia as a risk factor in the development of diabetic vascular complications. The effects of hyperglycemia on the vessel wall are not fully …
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Role of nuclear factor kappa B (NFkB) in the vascular complications of diabetes.
… inflammatory mediators in the progression of the vascular complications of diabetes was investigated. Specifically, the role of nuclear factor kappa B1 (NFĸB1). There were 2 approaches used in this study: i) a bioinformatics approach to determine what single nucleotide polymorphisms (SNP) may …
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Early mobilisation after coronary angiography to reduce back pain
… Savik, 2008) in order to reduce the chances of complications at the groin site (Chair, Taylor-Piliae, Lam and Chan, 2003). Due to this enforced supine bed rest, immobilization and restricted positioning, patients frequently experience back pain (Chair et al., 2003). Prolonged bed rest causes …
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Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells.
… is associated with the development of chronic vascular complications, which cause morbidity and premature mortality. Many studies have highlighted that maintenance of normal blood glucose levels in all people with diabetes is the most effective way in which chronic complications can be reduced …
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Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells.
Chronic complications of diabetes mellitus are a pathological consequence of unregulated levels of blood glucose leading to disorders of the vascular system. When investigating the vascular complications the changes in the endothelium are of particular significance as they are central to vascular …
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Arterial Calcification and the Clinical Implications on Stent Function
… with peripheral arterial disease (PAD), endovascular stenting can be a promising therapy that alleviates plaque obstruction and restores blood flow. However, stent fracture is a serious problem and it can lead to vascular complications, including restenosis. Stent fracture can be affected by …
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Elucidating the underlying mechanisms of diabetic endotheliopathy using patient specific induced pluripotent stem cells
… cause for impaired angiogenesis and reduced neovascularization that lead to microvascular injury and vascular complications. The pathogenesis for vascular complications arising from diabetes is complex. Elucidation of key underlying mechanisms will help the development of novel therapies and the …
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French osteotomy for cubitus varus in children: a long term study over 27 years
… repeat surgery). There were no neuro-vascular complications. The mean LCPI was +0.14. Conclusions: The results of the French osteotomy are comparable to the more technically demanding dome, step-cut translation and multi-planar osteotomies, with a lower complication rate. The …
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An In-Shoe Laser Doppler Sensor for Assessing Plantar Blood Flow in the Diabetic Foot
… 11 diabetes mellitus. Although neuropathy, microvascular disease and biornechanical factors are all implicated, the mechanism by which the tissue becomes pre-disposed to damage remains unclear. Recent theories suggest that the nutritional supply to the tissue is compromised, either by increased …
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A multimodal lens into vascular recovery in a preclinical model of peripheral arterial disease
… either through injury or disease. Cardiovascular complications are among the leading causes of morbidity and mortality in diabetic patients, and account for over 80\% of diabetes-associated deaths. One of the most serious is peripheral arterial disease (PAD), which is defined as a …
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Erythropoietin Signaling in Pancreatic Beta Cells in Homeostasis and in Models of Type 1 and Type 2 Diabetes
… characterized by chronic hyperglycemia and vascular complications leading to significant morbidity and mortality. The common feature in all forms of diabetes is the insufficient functional β-cell mass to maintain euglycemia; therefore, the promotion of β-cell survival and growth is a …
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High-Speed Photoacoustic Microscopy In Vivo
… invasive procedures such as endoscopy and intravascular imaging. To achieve high imaging speed, we have constructed a PAM system using a linear ultrasound array and a kHz-repetition-rate tunable laser. The system has achieved a 249-Hz B-scan rate and a 0.5-Hz 3D imaging rate: over ~6 mm ├ù 10 mm …
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Studies of EHEC and the complement system in renal diseases
… mutations who developed severe systemic vascular complications in the absence of kidneys and aHUS recurrences. To our knowledge this is the first patient treated with eculizumab, an anti-C5 antibody blocking the terminal complement cascade, in the absence of kidney tissue. In summary this …
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Role of Transient Receptor Potential (TRP) Channels in Nociception
… be involved in peripheral neuropathy as well as vascular complications in diabetes. ROS production plays a critical role in the progress of diabetes. I propose that lower levels of ROS up-regulate the expression TRP channels in the early stages of diabetes, leading to hyperalgesia, and higher …
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Serum 1, 5 Anhydroglucitol and Glycated Haemoglobin as Markers of Hyperglycemia in Type 2 Diabetes Mellitus at University Teaching Hospital, Lusaka, Zambia
… control overtime leads to micro and macro vascular complications; thus, it is important to utilize biomarkers that would predict poor control. Aims: In this study, we aimed to determine the diagnostic characteristics of 1,5 AG and HbA1c serum levels as biomarkers of hyperglycaemia in Type 2 …
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Mechanisms underlying enhanced bone marrow adipogenesis in diabetes
… associated with diabetes are due to secondary vascular complications that include both micro- and macro-vascular organ dysfunctions. Our recent studies show that vascular dysfunction and inadequate vessel repair in diabetes may potentially be due to impaired vasculogenesis (de novo vessel …
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The relationship between glucose metabolism byproduct, D-lactate, and vascular endothelial cell dysfunction and possible role in diabetes
… mellitus is a chronic disease associated with vascular complications. Vascular endothelial dysfunction caused by increased endothelial cell apoptosis contributes to diabetic cardiovascular complications. The glucose metabolic by-product, D-lactate, is elevated in diabetics and it is unknown …
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Impact of Transradial Approach in Patients with High Risk Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention and Abciximab on In-Hospital Clinical Outcomes and Bleeding Complications
… clinical outcomes by reducing bleeding and vascular complications when compared with transfemoral coronary intervention (TFI). The benefit of TRI might be enlarged in patients at high risk of bleeding. The purpose of this study was to evaluate clinical outcomes comparing transradial and …
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The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies.
… levels of blood glucose are associated with the vascular complications of diabetes. Microvascular complications lead to delayed wound healing in patients suffering from diabetes. Hypoxia and hyperglycaemia characterise a wound environment of a person with diabetes. Angiogenesis is central to …
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An Investigation for Genetic Susceptibility to Type 1 Diabetes Mellitus and its Microvascular Complications
… implicated in the pathogenesis of diabetic microvascular diseases. Genetic mutation through the genes coding for enzymes involved in glucose metabolism and immuno-regulatory mechanisms may contribute to the susceptibility to type I diabetes mellitus (TIDM) and its chronic microvascular diseases. …
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