Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"vascular cognitive impairment"”.
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Mechanisms of vascular cognitive impairment in cerebral small vessel disease and stroke
… brain and is a major contributor to stroke and vascular cognitive impairment (VCI). Although VCI poses a significant public health burden, the underlying biological processes and mechanisms remain poorly understood. The pursuit of this avenue of research has uncovered several mechanisms of …
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The Associations Between Cardiovascular Disease Risk Factors and Cognitive Function
Cardiovascular risk factors (CVRFs) are known to contribute to vascular cognitive impairment and dementia in later life. Their modifiability provides a promising avenue for reducing the risk of cognitive decline and dementia. This thesis summarizes the associations the current literature identifies …
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Pathological mechanisms of the ischemic white matter injury in animal model of lacunar infarction
… white matter injuries are associated with vascular cognitive impairment. Ischemic vascular cognitive impairment is caused by reduced signal conduction across white matter because of decreased signal conduction speed. Decreased signal conduction in ischemic white matter lesion results from …
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Investigating the role of TREM2 and neuroinflammation in an experimental model of chronic cerebral hypoperfusion
… cerebral hypoperfusion resulting from cerebrovascular disease is associated with the development of white matter damage, cognitive impairment and dementia. Although incompletely understood, recent studies suggest neuroinflammation is a key mechanism driving vascular pathology, white matter …
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Disease mechanisms and markers of progression in cerebral small vessel disease
… strokes, and is the major contributor to vascular cognitive impairment and dementia. Despite it being a major public health burden, understanding of the natural history is incomplete and the specific pathophysiological processes involved have not been fully elucidated. Consequently, there …
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Evaluating Magnetic Resonance Imaging and Serum Markers As Surrogate Endpoints for Clinical Trials in Cerebral Small Vessel Disease
… and is the most common pathology underlying vascular cognitive impairment and dementia. White matter hyperintensities, lacunar infarcts, cerebral microbleeds and brain atrophy are characteristic features on conventional magnetic resonance imaging (MRI). More sensitive methods such as …
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Effects of Sex and Aging in the Response to Global Cerebral Hypoperfusion
… to double by the year 2030 and triple by 2050. Vascular cognitive impairment and dementia (VCID) encompasses diseases that lead to cognitive decline and dementia due to cerebrovascular disease. VCID is the second most common form of dementia after Alzheimer’s disease, accounting for …
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Fatigue in Cerebral Small Vessel Disease and its Relationship to Cognitive Behavioural Symptoms
… brain. SVD is a leading cause of both stroke and vascular dementia, whilst cognitive behavioural symptoms such as fatigue are also frequent. Fatigue has a major impact on quality of life, yet little is known about its pathogenesis. This thesis aimed to assess the prevalence of, and possible …
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Sporadic cerebral small vessel disease and cognitive abilities
… small vessel disease (SVD) is a leading cause of vascular cognitive impairment, contributing to multiple neurological disorders ranging from stroke, to mild cognitive impairment and dementia. However, despite a huge number of studies on the subject, we have a limited understanding of how SVD …
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Mixed Dementia Induced by Right Common Carotid Artery Occlusion in an Alzheimer Mouse Model
Although vascular risk factors are associated with Alzheimer disease (AD), the effect of chronic cerebral hypoperfusion (CCH) on the progression of AD has not been widely evaluated. We aimed to evaluate whether CCH would aggravate the behavioral changes and plaque formation in an AD transgenic (Tg) …
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Investigation of inflammatory and oxidative stress mechanisms in the disruption of white matter structure and function following chronic cerebral hypoperfusion
Vascular cognitive impairment (VCI) describes a heterogeneous condition caused by cerebrovascular disease and disturbances in cerebral blood flow delivery. It is the second leading form of dementia and vascular factors such as hypertension, diabetes and obesity are associated with an increased risk …