Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"vascular cell adhesion molecule-1"”.
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The Regulation of Bone Marrow Mesenchymal Stem Cells by Vascular Cell Adhesion Molecule-1
Bone marrow (BM) mesenchymal stem cells (MSCs) form specialized perivascular microenvironments or niches in the BM that regulate hematopoietic stem cell (HSC) function. Interactions between MSC niche factors and HSCs ensure hematopoietic homeostasis. Vascular Cell Adhesion Molecule-1 (VCAM1) is …
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Effects of Cadmium on VCAM-1 Expression
… 뇌혈관 내피세포인 bEnd.3에서 카드뮴을 처리했을 때 그로 인해 변화되는 부착분자 (adhesion molecule)의 발현이 어떠한 신호전달로 매개되는지를 알아보기 위하여, 카드뮴을 처리한 후 Vascular cell adhesion molecule-1 (VCAM-1)의 변화와 Mitogen Activated Protein Kinase (MAPK) 저해제들이 VCAM-1의 변화에 미치는 효과를 관찰하였다. 그 결과, 카드뮴 처리 2시간째 VCAM-1 mRNA의 발현이 증가하였고 카드뮴 처리 4시간째에 VCAM-1 단백질 …
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Roles For B-Raf Kinase In The Specific Regulation of Α4Β1 Integrin In T Cells
<p>The regulation of integrin-mediated adhesion is of vital importance to adaptive and innate immunity. Integrins are versatile proteins and mediate T cell migration and trafficking by binding to ECM or other cells, as well as initiating intracellular signaling cascades promoting survival or …
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Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study
… as a biomarker of oxidative stress - and soluble vascular cell adhesion molecule-1 (sVCAM-1), and E-selectin, as markers of endothelial dysfunction. The plasma glucose to vitamin C ratios were also calculated. Daily clinical measures in the patients included Sequential Organ Failure Assessment …
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Investigating the impact of flavonoid metabolites on endothelial function and vascular inflammation
… has been associated with reduced cardiovascular disease risk, however, many in vitro studies have demonstrated effects using supraphysiological concentrations of flavonoids, overlooking the potential bioactivity of flavonoid metabolites and additive effects in combination. This thesis …
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Determining the effect of lipid nanoemulsions on insulin signaling and the inflammatory pathways at the Blood-Brain Barrier
… observed in AD and T2DM contributes to vascular inflammation, which in turn, leads to endothelial insulin resistance by impairing insulin receptor (IR) and insulin resistance substrate (IRS)-1(1). The insulin resistance leads to a compensatory increase in circulating insulin leading to …
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EVALUATION OF YAK-KONG SOYBEAN (GLYCINE MAX) FOR ITS PHENOLICS AND METABOLITES WITH A FOCUS ON ATHEROSCLEROSIS PREVENTION
… noncommunicable diseases especially cardiovascular diseases (CVDs) which have been the number one cause of death in globe. Soybean (Glycine max) has been supported by significant scientific evidence particularly on the risk reduction of CVDs. With the aim of seeking a competitive functional …
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Adverse Childhood Experience-conditioned serum from young adults promotes a dysregulated endothelial cell gene expression profile
… with an increased risk of developing cardiovascular disease (CVD) in adulthood, although the mechanisms leading to these outcomes remain poorly understood. Endothelial dysfunction is one of the earliest signs of cardiac pathology and can establish long-term changes in inflammatory state, …
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Interaction between cell adhesion molecules and stress hormones following different intensities of cycling exercise in obese males.
… (NE), and cortisol (COR)] and soluble cell adhesion molecules [soluble intercellular adhesion molecule 1(sICAM-1), soluble vascular cell adhesion molecule 1(sVCAM-1), and soluble endothelial selectin (sE-selectin)] over 24 hours following different intensities of exercise in obese men. …
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The vascular and anti-inflammatory activity of Cyanidin-3-Glucoside and its metabolites in human vascular endothelial cells
… has been associated with a reduced risk of cardiovascular disease (CVD), which is supported by evidence from human, animal and in vitro studies. However, owing to anthocyanins’ poor bioavailability and extensive metabolism, it is likely their metabolites are responsible for their reported health …
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Use of Echogenic Immunoliposomes For Delivery of Both Drug and Stem Cells For Inhibition of Atheroma Progression
… for Delivery of both Drug and Stem Cells for Inhibition of Atheroma Progression </strong></p> <p>By Ali K. Naji B.S. Advisor: Dr. Melvin E. Klegerman PhD</p> <p><strong>Background</strong> and significance: Echogenic liposomes can be used as drug and cell delivery vehicles that …
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Effects of IL-33 on the interaction between HMC-1 cells and human airway smooth muscle cells
… airways inflammation. The interaction of mast cells and human airway smooth muscle (HASM) cells play an important role in the characteristic pathological processes involved with asthma. The recently discovered cytokine, interleukin 33 (IL-33), is thought to play an important role in a variety …
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Role of 11β-hydroxysteroid dehydrogenase type 2 in protection against inflammation during atherogenesis: studies in the Apoe-/- /11β-HSD2-/- double knockout mouse.
… role in the development and progression of cardiovascular disease. Mineralocorticoid receptor (MR) over-activation has been implicated in atherosclerosis. In mineralocorticoid-target tissues, 11β- Hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates glucocorticoids, conferring aldosterone …
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Improving sulforaphane bioavailability from cooked broccoli
… the DSS-increased expression of IL-6, CCR2 and vascular cell adhesion molecule 1 (VCAM-1). Our next hypothesis was that the quercetin-3-O-sophoroside (QS), the major flavonoid in broccoli, could improve the bioavailability of SF from CB, by modifying the gut microbiota composition. Because no …
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Fine Particulate Matter, Neuropathologies, & Dementia
… and short-term PM2.5 exposure and biomarkers of vascular injury (E-selectin, vascular cell adhesion molecule-1 (VCAM-1)) in the cerebrospinal fluid (CSF). This question is important to investigate because of the growing evidence of the role of cerebrovascular disease in dementia as well as …
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Molecular mechanisms of radiation-induced brain injury
… cytokines (e.g., TNF-α, IL-1β, and IL-6),adhesion molecules (e.g., intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin), chemokine MCP-1, and matrix metalloproteinase-9 (MMP-9), are significantly impaired in aged brain. This study suggests …
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Mechanisms of IFN-gamma-mediated Resistance against Development of Toxoplasmic Encephalitis
Toxoplasma gondii, an obligate intracellular protozoan parasite, establishes a latent, chronic infection by forming cysts preferentially in the brain after replication of tachyzoites in various organs during the acute stage of infection. Chronic infection with T. gondii is one of the most common …
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Fatty acid regulation of adhesion molecule expression in human vascular cells.
… releases inflammatory cytokines and vasoactive molecules that produce an inflammatory reaction. The endothelium becomes increasingly permeable to LDL and an increase in adhesion molecule expression leads to leukocytes being recruited from the blood flow into the arterial wall. If the …