Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"variants of concern"”.
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SARS-CoV-2 Variants of Concern: Biological Implications of Immunogenicity and Comorbidity
… SARS-CoV-2, besides that it had a high degree of similarity to severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). The prior published research on these viruses set a strong foundation for the research approaches needed to …
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Development and Characterization of a Modified Vaccinia Ankara Vaccine Candidate Expressing the SARS-CoV-2 Spike Glycoprotein
… COVID-19 pandemic and the continued evolution of the virus to escape host immunity, new vaccines and refinement of first-generation vaccines to improve protection against SARS-CoV-2 variants of concern is vital. In Africa, the cost of vaccine manufacturing as well as the scarcity in resources …
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AN IMPROVED GENOMIC SURVEILLANCE APPROACH TO DISSECT THE SARS-COV-2 PANDEMIC
Genomic surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only approach to rapidly monitor and tackle emerging variants of concern (VOC) of the COVID-19 pandemic. Such scrutiny is crucial to limit the spread of VOC that might escape the immune protection conferred …
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Learning from pre-pandemic data to forecast viral antibody escape
… strain prevalence to make reliable predictions of variants of concern. To address this, we developed EVEscape, a generalizable, modular framework that combines fitness predictions from a deep learning model of historical sequences with biophysical structural information. EVEscape quantifies the …
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SARS-CoV-2 Variants and Vaccines
… intervention to prevent death. Due to a lack of previous immunity, SARS-CoV-2 spread around the globe at a rapid rate requiring the declaration of a pandemic and for countries to enforce national responses, such as widespread lockdowns and preventative measures including mask wearing and …
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MINING SARS-COV-2 PHYLOGENETIC TREES TO ESTIMATE CIRCULATING INFECTIONS AND PATTERNS OF MIGRATION
The SARS-CoV-2 pandemic led to the formation of very large databases of genomic viral data. These databases contain information on transmission dynamics, emergence and evolution of SARS-CoV-2. However, extracting this information from sequences is difficult, as most methods of analyzing viral …
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Interpretations of Machine Learning and Their Application to Therapeutic Design
… discover overinterpretation as a failure mode of deep neural networks, and discuss how ML methods can be applied for therapeutic design, including a pan-variant COVID-19 vaccine. While ML models are widely deployed and often attain superior accuracy compared to traditional approaches, deep …
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Learning from pre-pandemic data to design and test future-proof therapeutics
… viral mutations to enable early detection of variants of concern and design vaccines and therapeutics that are resilient to future viral evolution. However, current strategies for viral evolution prediction are not available early in a pandemic and have limited predictive power – …
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COVID-19 Variant Analyzer through Genomic Sequences and Jaccard Similarities
… surveillance to track the emergence and spread of SARS-CoV-2 variants. This study developed a novel computational framework to enhance variant detection by leveraging a database-driven approach and genomic sequence analysis. The framework utilizes MySQL database architecture where each variant …
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Graph-Based Computational Approaches for Modeling Viral Evolution
… how pathogens adapt, spread, and generate new variants of concern. Yet, it remains challenging due to high mutation rates, minimal sequence divergence, and the scale of modern genomic data. Most phylogenetic trees enforce a strictly bifurcating structure that struggles to represent recurrent …
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Evolution-dependent SARS-CoV-2 vaccination success determined by neutralizing antibodies and reliability of point-of-care testing
… and isolated an early Wuhan-like type (wt) of SARS-CoV-2 and the variants of concern Alpha, Delta, Omicron BA.1, and Omicron BA.2. Moreover, we established a Vero cell-based virus neutralization test to validate various diagnostic systems and to estimate vaccination success. Since RT-qPCR …
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Genetic diversity of sars-cov-2 in southern province of Zambia.
… coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has spread globally with catastrophic effects on the public health system. Four main Variants of Concern (VOCs), namely Alpha, Beta, Delta and Omicron, have been associated with waves of high transmission …
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Genetic diversity of sars-cov-2 in southern province of Zambia.
… coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has spread globally with catastrophic effects on the public health system. Four main Variants of Concern (VOCs), namely Alpha, Beta, Delta and Omicron, have been associated with waves of high transmission …
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Aptamers that bind SARS-CoV-2 spike protein for COVID-19 rapid diagnostics and therapeutics
… and vaccines. One hurdle is the emergence of SARS-CoV-2 variants of concern, including the Omicron variant, which has enhanced infectivity and immune invasion. Improved rapid tests can limit viral spread by informing individuals of their infection status for personal risk assessment as well …
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Evolution of targets at the host-pathogen interface
… 1: Introduction <br>Background information of the origin, pathophysiology, and therapeutic options for both the bacterial pathogen Mycobacterium tuberculosis (Mtb) and betacoronaviruses – the Severe Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in particular – is presented. Chapter 2: …
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Engineering translational vaccine delivery systems with the polyphenol tannic acid
Supramolecular biomaterials, which are capable of spontaneous assembly via diverse non- covalent interactions, represent an exciting frontier in drug delivery due to their ease of formulation and modularity. Tannic acid (TA) is a naturally-occurring compound that has a demonstrated ability to …
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Responding to an Evolving Pandemic: Characterisation of Emerging Evolving Viruses and Population Immunity by the Example of SARS-CoV-2
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human population in 2019 presented extraordinary challenges to the scientific community, and at the same time unique opportunities. Following the evolution of a novel human virus, together with the development of …
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From Sample to Answer: Innovations in sample processing and CRISPR-based diagnostics for enhanced clinical translation and field deployment
The recent (re)emergence and rapid spread of infectious disease agents underscore the urgent need for effective disease prevention and control strategies. Accurate and timely diagnostics serve as the base for effective disease management, enabling the rapid identification of disease outbreaks, …
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Characterising the magnitude and breadth of T cell responses to SARS-CoV-2 vaccination
… most studies frequently measure the magnitude of spike-specific CD4 and CD8 responses, only a few studies have characterised their breadth of targeting across the spike. This characterization is crucial for predicting cross-reactivity in T cell responses against emerging variants of concern …
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Investigating SARS-CoV-2 immune responses in children
… oSen observed in adults. A severe manifesta<on of SARS-CoV-2 infec<on in children is mul<system inflammatory syndrome (MIS-C), a delayed hyperinflammatory disease that occurs aSer exposure to SARS-CoV-2 and shares clinical features with Kawasaki disease (KD). MIS-C develops in a small propor<on …
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