Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 2962 for “"variants"”.
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Goddard-problem variants
The problem of maximizing the altitude of a rocket in vertical flight has been extensively analyzed by many writers since the early days of rocketry. In the beginning, solutions were obtained using the classical theory of the Calculus of Variations, and later using Optimal Control theory. For …
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Characterizing Boolean satisfiability variants
We survey variants of the Boolean Satisfiability problem from over the years and organize them in what we believe to be the most comprehensive list of known results in SAT variants. We propose a new notation to specify them so that the problems can be compared with no ambiguities, and so that new …
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Molecular analysis of peasnRNA variants
… and sequenced. Comparison of the pea snRNA variants with other organisms suggest that functionally important primary sequences are conserved phylogenetically even though the overall sequences have diverged substantially. Structural variations occur in regions required for U1-specific protein …
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Common variants in antibody deficiencies
… with the genes known to harbour IEI-related rare variants. Finally I explore the shared genetic architecture of CVID, SIgAD, and serum antibody production production, and I adduce my findings in an argument for the relevance of common-variant analysis in the study of IEIs.
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MOVE: Mobile Observers Variants and Extensions
<p>Traffic state estimation is a fundamental task of Intelligent Transportation Systems. Recent advances in sensor technology and emerging computer and vehicular communications paradigms have brought the task of estimating traffic state parameters in real-time within reach.</p> <p>This has led to …
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Geometric Hitting Sets and Their Variants
<p>This thesis explores a few geometric optimization problems that arise</p><p>in robotics and sensor networks. In particular we present efficient</p><p>algorithms for the hitting-set problem and the budgeted hitting-set problem.</p><p>Given a set of objects and a collection of subsets of the …
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Rare Genetic Variants and Cancer Susceptibility
… breast cancer is known to be conferred by common variants, identified through GWAS, together with some rarer variants conferring higher disease risks. The latter, identified through genetic linkage or targeted sequencing studies, includes protein-truncating variants and some rare missense variants …
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Engineering structural variants with prime editing
… and the systematic exploration of structural variants.
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SARS-CoV-2 Variants and Vaccines
… to prevent infection but due to novel variants that arose, this later changed to preventing severe infection which may require hospitalisation. Several novel variants arose with substitutions occurring in the spike glycoprotein. As the spike protein is used by the virus for viral entry, …
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Biochemical and Functional Analyses of PANX1 Variants
… domains by introducing naturally occurring variants reported in melanoma and assessed their impact on the channel function of PANX1 at the cell surface. From this, we discovered a novel tyrosine phosphorylation site at Tyr150, that when disrupted via a missense mutation resulted in …
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Analysis of soluble high-affinity PD1 variants
… pay load. In this study soluble PD1 (sPD1) variants were generated with increased binding properties to PD-L1. The sPD1 variants were analysed using solid-phase protein competition studies as well as live pancreatic cell assays to assess their immune checkpoint inhibitory functions. These …
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Cross-Species Evolution of New AAV Variants
<p>Therapeutic gene transfer and genome editing require effective delivery of genetic cargo to target cells and tissues. Recombinant adeno-associated viral (AAV) vectors are a promising delivery platform, but ongoing clinical trials continue to highlight a relatively narrow therapeutic window. …
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Purepecha Aspirated Consonants and Their Phonetic Variants
… In Azajo Purepecha there are no documented variants of pre-aspiration.</p>
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Functional interpretation of cancer-associated genetic variants
… have hitherto identified several common genetic variants that may significantly modulate cancer susceptibility. However, the precise molecular mechanisms behind these associations remain largely uncharacterized, creating barriers to understanding the biological processes behind oncogenesis. This …
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Methods and models of screening genomic variants
Genomes are the basis of human biology and human disease. Understanding the role of each gene on a healthy or diseased phenotype requires an intervention to causally link between genotype and phenotype. Advances in RNA-guided endonucleases have enabled such pooled screens in human cells. I first …
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Approximate nearest neighbor and its many variants
This thesis investigates two variants of the approximate nearest neighbor problem. First, motivated by the recent research on diversity-aware search, we investigate the k-diverse near neighbor reporting problem. The problem is defined as follows: given a query point q, report the maximum diversity …
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Understanding and Improving Identification of Somatic Variants
… to understand the entire spectrum of somatic variants to gain more insight into mutations that occur in different cancers for development of better diagnostic, prognostic and therapeutic tools. This thesis outlines our work in understanding somatic variant calling, improving the identification …
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Apolipoprotein E variants, plasma lipids, lipoproteins and dysApolipoprotein E variants, plasma lipids, lipoproteins and dysβLipoproteinaemia during pregnancy in Zimbabwean women.
… pregnancy, To examine the prevalence of apoE variants, To evaluate dysβlipoproteinaemia in pregnancy, The correlation between dysβplipoproteinaemia and the apoE genotypes. This is the first study to systematically examine lipids and lipoproteins during pregnancy in black Africans.
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Characterizing CMT-causing variants in tryptophanyl- tRNA synthetase
… (CMT) disease, have been linked to variants identified in these enzymes. I created a humanized yeast model to assess the underlying disease-causing mechanism associated with two CMT variants, H257R and D314G, present in the human tryptophanyl-tRNA synthetase (WARS1). Using proteomic …
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Spectroscopic investigation of phytochromes and NIR fluorescent variants
… Various plant, cyanobacterial, and bacterial variants regulate biological processes through the light dependent switching between metastable states that absorb red and far-red light (Pr and Pfr). The aim of the work was the elucidation of the mechanisms of photoinduced processes in different …
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