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Showing 1 to 2 of 2 for “"var genes"”.
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Characterization of a Novel Sensing Mechanism Governing Antigenic Variation in P. Falciparum
… expresses a multi-copy gene family called var in the intraerythroyctic stages of its life cycle in a mutually exclusive manner. var genes encode the chief antigenic and virulence determinant of P. falciparum, PfEMP1, and switching between active genes results in antigenic variation, …
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Identifying parasite virulence factors and host genetic and immunologic factors that contribute to severe malarial outcomes in Ugandan children
… PCR to estimate transcript levels of var genes encoding P.falciparum erythrocyte membrane protein 1 (PfEMP1), and used plasma to quantify a number of cytokines, chemokines, angiogenic growth factors, soluble EPCR and erythropoietin with ELISA-based assays. The work presented in this …