Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 24 for “"vancomycin resistant enterococci"”.
-
Optimal Control Applied to a Mathematical Model for Vancomycin-Resistant Enterococci
Enterococci bacteria that cannot be treated effectively with the antibiotic vancomycin are termed Vancomycin-Resistant Enterococci (VRE). In this thesis, we develop a mathematical framework for determining optimal strategies for prevention and treatment of VRE in an Intensive Care Unit (ICU). A …
-
Molecular Characterization of Vancomycin-resistant Enterococci from Clinical and Surveillance Specimens
BACKGROUND: Vancomycin-resistant enterococci(VRE) were first detected in Europe in 1986, and have been isolated from hospitalized patients worldwide. VanA resistance, characterized by high level resistance to vancomycin and teicoplanin, is the most prevalent in clinical enterococcal isolates. To …
-
Repurposing Antibacterial Compounds and Natural Products to Combat Vancomycin-Resistant Enterococci
… Among the most concerning pathogens are vancomycin-resistant Enterococcus (VRE), which causes serious bloodstream, urinary tract, and wound infections, particularly in hospitalized patients. This thesis explores two complementary strategies to address this challenge: natural product …
-
Detection of Vancomycin resistant Enterococci from clinical specimens at University Teaching Hospitals
Enterococci are commensal gram-positive bacteria in the gastrointestinal tract of humans. They have emerged as important nosocomial pathogens due to their ability to acquire and confer antimicrobial resistance genes, hence making management of infections due to Enterococcus species difficult. …
-
Detection of Vancomycin resistant Enterococci from clinical specimens at University Teaching Hospitals
Enterococci are commensal gram-positive bacteria in the gastrointestinal tract of humans. They have emerged as important nosocomial pathogens due to their ability to acquire and confer antimicrobial resistance genes, hence making management of infections due to Enterococcus species difficult. …
-
Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
… the gastrointestinal tract and the soft tissues. Vancomycin has been one of most important agents for the treatment of gram-positive bacterial infections. The emergence and spread of vancomycin resistance has become a serious public health issue and vancomycin resistant bacteria are world’s …
-
Molecular Characteristics and Dissemination Mechanism of Vancomycin-Resistant Enterococci: A Tertiary vs. Non-Tertiary Health Care Hospitals
Vancomycin-resistant enterococci (VRE) have been endemic in Korea as a nosocomial pathogen. The aim of this study was to examine genetic relatedness and dissemination mechanism by comparative analysis of the antimicrobial and biomolecular characteristics of VRE isolates from tertiary and …
-
Assessing the Presence of Antibiotic-Resistant Enterococcus in Reclaimed Water Used for Spray Irrigation
… the Mid-Atlantic and Midwest regions of the US. Enterococci were isolated using membrane filtration, confirmed using biochemical tests and PCR, and tested for antimicrobial susceptibility using the Sensititre® dilution system. We detected total enterococci and vancomycin-resistant enterococci …
-
Mechanistic Insights Into Vancomycin Resistance In Clostridioides Difficile
… become more hypervirulent over the last decade. Vancomycin is currently a frontline antibiotic for the treatment of <em>C. difficile</em> infections. Yet, strains of <em>C. difficile</em> are becoming non-susceptible to vancomycin. Emergence of the vancomycin non-susceptible phenotype has led to …
-
Potential of bacteriocin producing bacteria to control VRE infection
… the last decade. It is estimated that antibiotic resistant pathogens cause up to 700,000 deaths each year. The Centre for Disease Control ranks vancomycin resistant enterococci as a serious threat. They estimate that in 2017 alone there were at least 54,500 cases in hospitalized patients. The rise …
-
The prevalence of toxin-antitoxin systems and their tractability as novel antimicrobial targets
… prevalence of TA systems in clinical isolates of vancomycin-resistant enterococci and methicillin-resistant S. aureus to validate TA systems as an antibacterial target. Two TA systems, Axe-Txe and RelBE, were found to be common among the pathogenic bacteria surveyed and were therefore further …
-
Rectal culture screening for vancomycin-resistant enterococcus in chronic haemodialysis patients
Infection or colonisation with vancomycin-resistant enterococci (VRE) is common in chronic haemodialysis(HD) patients. However, there is limited information on the duration of VRE colonisation or on the reliability of consecutive negative rectal cultures to determine the clearance of VRE in chronic …
-
Biosynthesis of the antimicrobial peptide epilancin 15X
… pathogenic bacteria, including methicillin-resistant S. aureus and vancomycin-resistant Enterococci. Epilancin 15X contains an unusual N-terminal lactate group (Lac) that could be important for its bioactivity. To understand its biosynthesis, the epilancin 15X gene cluster was identified. …
-
Total Synthesis of Naturally Occurring Antimicrobial Peptides
… potent antimicrobial activity against highly resistant Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE), and several species of Streptococci. Previous chemoenzymatic synthesis, semi-synthesis, and combinatorial …
-
Gram-positive infections in patients with end-stage renal disease
… of infection. The effect on faecal carriage of vancomycin resistant enterococci (VRE) and Clostridium difficile toxins in patients treated with CAPD when empiric cephalosporin therapy was substituted for piperacillin/tazobactam was investigated. The introduction of piperacillin/tazobactam …
-
Functional and structural characterization of the mevalonate diphosphate decarboxylase and the isopentenyl diphosphate isomerase from Enterococcus faecalis
… blood stream and the endocardium), and multidrug-resistant strains have become a serious issue across countries. Vancomycin, a FDA-approved drug for the disruption of the bacterial cell wall biosynthesis, has been utilized to treat infectious diseases caused by Enterococci; however, the prevalence …
-
Genomics & Gastroenteritis - A Journey in Applied Epidemiology
… the prevalence and genomic profile of vanA vancomycin resistant enterococci (VRE) in Victorian health care facilities and compare this to patterns of patient movement between hospital networks. This study aimed to inform future studies on the transmission of vanA VRE and to provide valuable …
-
Genomics & Gastroenteritis - A Journey in Applied Epidemiology
… the prevalence and genomic profile of vanA vancomycin resistant enterococci (VRE) in Victorian health care facilities and compare this to patterns of patient movement between hospital networks. This study aimed to inform future studies on the transmission of vanA VRE and to provide valuable …
-
ANTIMICROBIAL CHARACTERIZATION AND THERAPEUTIC APPLICATIONS OF NOVEL SYNTHETIC THIAZOLE COMPOUNDS AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCI AND ENTEROCOCCI
… available antimicrobials. The emergence of drug-resistant bacterial species, namely methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), has limited the efficacy of several classes of antibiotics. Compounding this problem further is that many large …
Page 1 of 2