Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"valvular heart disease"”.
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Valvular heart disease: novel epidemiological and imaging studies
… and antibiotics have entered routine use, valvular heart disease (VHD) in the developed world is mostly degenerative in origin, rather than rheumatic. Our population is increasing with age, and therefore the burden of VHD is likely to increase. Despite this, the epidemiology & …
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Neurohormonal and inflammatory markers in valvular heart disease
Chronic valvular heart disease is characterised by compensatory mechanisms that result in a long asymptomatic phase associated with variable disease progression. After the development of symptoms or left ventricular dysfunction, mortality is high without surgical intervention. Currently there is no …
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Power velocity integral technique for quantification of flow in valvular heart disease
… referred to as regurgitant flow, associated with valvular heart disease has been an elusive medical goal. To date, techniques based on ultrasound have been unsatisfactory due to weak assumptions and indirect estimations. Here, instead, the proposal is to estimate regurgitant flow directly from the …
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Investigation of circulatory and tissue-specific metabolomic biomarkers in valvular heart disease using mass spectrometry
… metabolic biomarkers in patients with rheumatic heart disease (RHD) and degenerative aortic stenosis (AS), compared to matched, healthy controls. The study hypothesis was that cardiac tissue obtained from heart valve biopsies from RHD and degenerative AS patients would have distinct histological …
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A comparison of hemodynamic performance in mehcanical and biological heart valve prostheses
Heart valve prostheses are used to replace heart valves in patients afflicted with valvular heart disease. The malfunctioning heart valve adversely affects the fluid mechanical performance. While the choice of mechanical VS biological valve prostheses is dependent on the patient, the biological …
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Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers
Background: Rheumatic heart disease (RHD), concomitant to valvular damage, heart failure, arrhythmias and pulmonary hypertension is the major source of cardiovascular morbidity and mortality in the young, predominantly in low- and middle-income countries (LMICs). We investigated the association of …
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Optimisation of Surgical Timing in Rheumatic Mitral Valve Disease
Rheumatic heart disease is a consequence of Group A streptococcal infections, and disproportionately affects the world’s most disadvantaged people. Whilst the disease has been essentially eradicated from nonindigenous populations in Australia, Indigenous Australians continue to have some of the …
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Early prototyping and testing of a model of an expandable heart valve apparatus for paediatric deployment
Valvular heart disease is any abnormal condition which involves one or more of the heart valves - the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right. Valves diseases in infants are congenital and their effect is to burden the heart with an increased work to …
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Clinical characteristics, causes, adherence to heart failure treatment guidelines and mortality of patients with acute heart failure: the Groote Schuur Hospital experience
Background: There is limited information on acute heart failure (AHF) and the treatment thereof in sub-Saharan Africa. Therefore, the aim of this study was to describe the clinical characteristics, causes, adherence to heart failure (HF) treatment guidelines and mortality of patients presenting to …
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A tri-phasic continuum model for the numerical analysis of biological tissue proliferation using the Theory of Porous Media. Application to cardiac remodelling in rheumatic heart disease
… describing the mechanotransduction of Rheumatic Heart Disease, in order to study and predict long-term effects of new therapeutic concepts to treat inflammatory heart diseases and ultimately, estimate their effectiveness to prevent heart failure. Attention is given to Rheumatic Heart Disease …
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Clinical characteristics and outcomes of children with rheumatic heart disease: a global rheumatic heart disease registry (REMEDY) sub-analysis
Background: Despite Rheumatic Heart Disease (RHD) contributing to an estimated disease burden in 2019 of 40 million people and 285 500 deaths, few studies document the characteristics and outcomes in children. We undertook a sub-analysis of children from the multi-centre prospective two-year global …
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Normal and abnormal findings from exercise stress ECG vs. post-exercise echocardiography studies in a series of hypertensive and normotensive individuals
… patients had: history of myocardial infarction; valvular heart disease; ECG evidence of abnormal Q waves, left ventricular hypertrophy (LVH) with abnormal ST/T wave pattern, or left bundle branch block (LBBB); medications that would alter blood pressure responses or ECG interpretation; …
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The Role of Mammalian Lipid Transport Protein ORP1 During Coxiella Burnetii Infection
… an intracellular bacterium that causes the human disease Q fever. C. burnetii is transmitted from infected animals to humans through inhalation of infectious droplets. Acute Q fever is a flu-like illness lasting 10-14 days. Patients often have respiratory symptoms and present with pneumonia. …
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Poor anticoagulation control in patients taking warfarin at a tertiary and district-level prothrombin clinic in Cape Town, South Africa
… The most common indications for warfarin were valvular heart disease (45.7%) and atrial fibrillation (25.1%). The mean TTR was 47%, with only 91/363 patients having good INR control. In a multivariate model adjusted for age, sex, clinic and target INR, patients aged ≥55 years were more likely …
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Predicting pulmonary hypertension and outcomes in patients with left heart disease
… pulmonary arteries resulting from a variety of diseases including chronic infectious diseases, lung diseases and left heart diseases (LHD). It is a global health problem and accounts for a substantial portion of cardiovascular disease. PH due to LHD (PH-LHD) is credited to be the most common …
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Spectrum Of Causes Of Isolated Aortic Regurgitation At A South African Public Sector Tertiary Care Institution
… primary abnormalities of the aortic valve, peri-valvular apparatus and/or the aortic root and the ascending aorta. Whereas the etiology and mechanisms of AR are relatively well described in Europe and North America, little information exists about their spectrum and frequency in sub-Saharan and …
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In silico and in vitro analysis of calcific and rheumatic aortic stenosis
Aortic stenosis (AS) is a valvular heart disease characterised by the narrowing of the aortic valve opening that restricts blood flow from the left ventricle to the aorta. AS is caused by different pathologies that each result in a specific valve opening morphology. The most common types of AS are …
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Design and development of an electrospun polymeric transcatheter heart valve for tissue engineering
The growing global burden of valvular heart disease (VHD) remains a significant challenge to overcome. Despite the advancements in heart valve replacements and the ground-breaking introduction of transcatheter valve technologies, current solutions offer suboptimal therapy as they either require …
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Normal and Abnormal Findings from Exercise Stress ECG, Post-Exercise Echocardiography and Angiography Studies in a Series of Hypertensive and Normotensive Individuals
… patients had: history of myocardial infarction; valvular heart disease; ECG evidence of abnormal Q waves, left ventricular hypertrophy (LVH) with abnormal ST/T wave pattern, or left bundle branch block (LBBB); medications that would alter blood pressure responses or ECG interpretation, …
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