Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"valproic acid"”.
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Placental epigenetic modifications and development in valproic acid-induced teratogenesis
Valproic acid (VPA) is an anti-epileptic and a teratogen. In utero exposure to VPA is associated with congenital malformations and neurodevelopment disorders. VPA exerts its teratogenic effects through epigenetic dysregulation, which interferes with tissue development and function. Evidence …
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A Nomogram for Valproic Acid and the Effect of Missed Doses
… or missed. For a neuropsychiatric agent like valproic acid (VPA), rational dosing recommendations are of particular importance. VPA is subject to therapeutic monitoring using total concentrations. Due to non-linear binding of VPA to plasma proteins, current dose titration schemes for VPA are …
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Metabolism and pharmacokinetic studies of valproic acid using stable isotope techniques
Valproic acid (VPA) is an anticonvulsant agent widely used in the treatment of several types of epileptic seizures. The drug is unique within its therapeutic class, in terms of its mechanism of action, its chemical structure, as well as its extensive biotransformation into at least 16 different …
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Valproic acid: A neural outgrowth model for the autism spectrum disorder
1 PDF file (vii, 43 pages)
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Valproic Acid-Induced Teratogenesis in Japanese Rice Fish (Oryzias Latipes) Embryogenesis
Valproic acid (VPA) was introduced as an antiepileptic in 1967 in France and it has become the most prescribed anticonvulsive drug therapy worldwide since then. In the clinic, valproic acid is selected to treat absence seizures, myoclonic seizures, generalized tonic-clonic seizures, atonic attacks …
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Valproic Acid Disrupts Hematopoiesis in Xenopus Laevis Through the Inhibition of Histone Deacetylase 3.
… employed the class I selective HDAC inhibitor, valproic acid (VPA), to identify hdac3 as an essential mediator of primitive hematopoiesis. Exposure to VPA during gastrulation results in a marked and specific block of primitive hematopoiesis in Xenopus embryos. Furthermore, pharmacological and …
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Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development
Many antiepileptic drugs on the market, including valproic acid (VPA), have a wide range of therapeutic effects in addition to treating epilepsy. In recent years, the use of VPA in the treatment of psychiatric conditions has been on the rise. However, studies have shown that in utero exposure to …
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Neurotrophic Theory of Accelerated Temporal Cortex Maturation in the Valproic Acid Rat Model of Autism
… with exposure to the autism-linked teratogen valproic acid (VPA). My overarching hypothesis was that the slow maturation of TeA neurons during the first three weeks of postnatal development is a result of low local production and/or secretion of brain derived neurotrophic factor (BDNF), and …
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The preparation and characterization of multi-component systems in drug pre-formulation
… (used to treat acute myelogenous leukaemia) and valproic acid (for treatment of epilepsy and bipolar disorders). Allopurinol and 6-thioguanine were fairly intractable, yielding very limited results following co-crystallization trials with a series of co-formers. However, a new polymorph of one of …
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Molecular Enhancement of Alpha 7 Integrin to Ameliorate Muscular Dystrophy
… Two such molecules were identified: HTCB and valproic acid increase alpha7 levels about 1.4-fold and 2-fold respectively. Valproic acid also activates the Akt/mTOR pathway, promoting myotube hypertrophy and survival. To test their effects in vivo, the molecules were administered to mdx/utr …
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Characterization and application of human pluripotent stem cell-derived neurons to evaluate the risk of developmental neurotoxicity with antiepileptic drugs in vitro
… impact of four major AEDs, namely phenobarbital, valproic acid, carbamazepine and lamotrigine, on cell viability, cell cycle and differentiation of TERA2.cl.SP-12 into neurons was studied. All AEDs tested reduced differentiating stem cell viability. Valproic acid and carbamazepine increased …
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Analysis of gene expression alterations in premalignant progression from normal mammary epithelium to ductal carcinoma in situ by multiple orthogonal tools
… as IGF-1 signaling, integrin signaling and fatty acid biosynthesis. To further enrich the expression data and identify low abundance transcripts we employed next generation sequencing (RNA-Seq) using Illumina Genome Analyzer GAIIx. Analysis of the sequencing data showed 295 consistently …
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Notch Signaling in Human Neuroblastoma Cells
… from degradation. In addition, we show that valproic acid (VPA) induces differentiation of neuroblastoma cells by modulation of the Notch signaling cascade. Aberrant signaling through the EGF receptor is involved in the genesis of some human cancers. Several reports have shown cross talk …
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The Domestic Chick as a Model for Studying Early Social Behaviors and Dopaminergic Dysfunctions in Autism and Fragile X Syndrome
… we will describe how embryonic exposure to valproic acid (VPA), a compound known to increase the risk of developing ASD and used in animals to model the disorder, impacts chicks’ early social orienting abilities, motivation, and dopaminergic development. Then, we will present the design and …
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Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
… we show that the histone deacetylase inhibitor valproic acid induced differentiation of neuroblastoma cells, in conjunction with activation of Notch-1 signaling. In addition, we also noted that the expression of the Notch target HES-1 was primarily regulated by ERK-MAP kinase signaling in a …
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Histone deacetylase inhibitors as novel neuroprotective agents in in vitro and in vivo models of Parkinson’s disease
… of the HDAC-Is, suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) were investigated in in vitro and in vivo models of PD. Neither inhibitors protected dopaminergic cell lines, SH-SY5Y and N1E-115, against hydrogen-peroxide (H2O2) and MPP+-induced toxicity. Except, at the highest …
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Design, synthesis, and analysis of conjugated activators for modulation of alternative splicing
… activators such as sodium phenylbutyrate and valproic acid, to viral vectors encoding antisense oligonucleotides. In particular, a synthetic peptide-oligonucleotide conjugate containing a short chain of arginine-serine dipeptides to mimic the RS domain has been shown to redirect splicing …
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