Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"valproate"”.
-
Neuromolecular basis of anomalous feeding behaviour in the valproate rat model of autism
Autism spectrum disorder (ASD), which affects circa 1% of the global population, is characterized by impairments in social communication, interaction, language disability, sensory anomalies, repetitive behaviours, and intellectual disability. Aberrant feeding behaviour is a common comorbidity of …
-
Epigenetic Therapy of Lung Cancers: Anti-tumoral effect of valproate on small cell lung cancer
… of this study was to evaluate the ability of valproate (VPA) to improve efficacy of chemotherapeutic regimen in SCLC. We show that VPA directly induces apoptosis of SCLC cell lines at concentrations relevant for clinical uses. Furthermore, VPA synergizes with two chemotherapeutic regimen used …
-
Regulation Of Inositol Biosynthesis And Cellular Consequences Of Inositol Depletion: Implications For The Mechanism Of Action Of Valproate
… </p> <p>Previous studies have shown that valproate (VPA), a branched chain fatty acid that has been successfully used for the treatment of bipolar disorder, epilepsy, and migraine, causes inositol depletion by inhibiting MIPS in vivo but not in vitro, which suggests that inhibition is …
-
The role of folic acid supplementation on exencephaly induced by maternal exposure to sodium valproate in the TO mouse
… at birth. This frequency is enhanced by sodium valproate (VPA), an anticonvulsant drug. Earlier workers have reported that folic acid (FA) supplementation during periconceptional period prevents a substantial proportion of neural tube defects (NTD). The mechanism of preventive effect of FA is …
-
ΜΟΝΟΘΕΡΑΠΕΙΑ ΜΕ ΜΙΑ ΔΟΣΗ ΒΑΛΠΡΟΙΚΟΥ ΝΑΤΡΙΟΥ ΤΗΝ ΗΜΕΡΑ ΣΕ ΠΑΙΔΙΑ. ΚΛΙΝΙΚΟΕΡΓΑΣΤΗΡΙΑΚΗ ΜΕΛΕΤΗ
MONOTHERAPY WITH ONCE DAILY SODIUM VALPROATE WAS GIVEN IN 55 CHILDREN WITH EPILEPSY. FOR 35 PATIENTS (35/55) ALREADY ON SODIUM VALPROATE TWICE DAILY THE SAME DAILY DOSE WAS GIVEN ONCE DAILY. THEY WERE ALREADY FREE OF SEIZURES AND CONTINUED SO AFTER THE CHANGE. 19 OF THEM HAD AN ABNORMAL EEG WHILE …
-
Dynamic histone modifications at the promoters of Hox genes in embryonic stem cells
… Treatment with the histone deacetylase inhibitor valproate induced a coordinate increase in the levels of H3K9ac and H3K4me3 at all Hoxb promoters, but not other genes, whilst H3K27me3 was unaffected. Such increases were not maintained upon removal of the inhibitor. All Hoxb genes were silent in …
-
Valproic Acid-Induced Teratogenesis in Japanese Rice Fish (Oryzias Latipes) Embryogenesis
… as Japanese medaka, as an animal model to study valproate-induced teratogenesis during the period of embryogenesis. Fertilized embryos of Japanese rice fish at three developmental stages (group A: 0–2 dpf; group B: 1–3 dpf; group C: 4–6 dpf) were exposed to VPA (0–80 mM) for 48 hrs. The amounts …
-
A study of acetylcholinesterase and cholinesterase in the fetal mouse brain and a study of the effects of three teratogens, vitamin A, cyclophosphamide and sodium valproate on the fetal mouse central nervous system
… vitamin A, cyclophosphamide and sodium valproate when administered during embryonic development, on gross fetal parameters in C3H mice including embryolethality, gross morphological abnormalities, fetal weight, brain weight, brain acetylcholinesterase and its isoenzymes, and in some …
-
Health technology assessment for levetiracetam in the treatment of newly diagnosed epilepsy in the South African Public Health Sector
… lamotrigine, carbamazepine, phenytoin and valproate. The current first-line epilepsy treatment in South Africa is lamotrigine, phenytoin or carbamazepine. Levetiracetam is under consideration for use as a first-line treatment due to the reported minimal serious side effects, its ease of …
-
Pharmacist input into patients' self-reporting of adverse drug reactions.
… to 464 patients prescribed carbamazepine, sodium valproate, trazodone, doxepin and co-proxamol from three participating medical practices in a pilot study. Subsequently, it was sent to all patients (n=2307) prescribed tramadol, fentanyl patch, venlafaxine, nefazodone, citalopram, moclobemide, …
-
Quantitative assessment of the pharmacotherapy of biopolar disorder and schizophrenia
… was 4 (95% CI 3 to 9). Neither carbamazepine nor valproate was more effective than lithium. The response rate ratios were 1.01 (95% CI 0.54 to 1.88) for lithium compared to carbarnazepine and 1.22 (95% CI 0.91 to 1.64) for lithium against valproate. Haloperidol was no better than lithium on the …
-
Improving care coordination through virtual warm handoffs in telepsychiartry
… for patients on medications like lithium, valproate, or clozapine that require specific monitoring as per guidelines. Purpose: This QI/EBP DNP project assessed whether implementing a structured provider-to-nurse SBAR handoff would enhance the completion of nursing assessments in a community …
-
The Prevalence Of Metabolic Disorders And Their Associated Risk Factors In Forensic Patients With Schizophrenia Spectrum Disorders On Clozapine Compared To Haloperidol At Valkenberg Hospital
… 25 patients on concurrent Clozapine and sodium valproate did, (χ 2 (1) = 6.051, p = .023 V = .359). In terms of metabolic disorders, a significantly higher proportion of patients in the study group has hypertension and hyperlipidaemia (p = .003 and p = .021 respectively). Less than 25% of all …
-
Cerebral blood flow in the non-human primate : an in vivo model and drug interventions
… agonist used for treatment of migraine; sodium valproate (an anti-epileptic drug); nimodipine, a calcium channel blocker and nitro-glycerine, a vasodilator used for angina. Arterial blood pressures were recorded from a catheter in the femoral artery and heart rates were concurrently monitored. …
-
Disturbo bipolare e cefalea a grappolo: identificazione di geni e pathway molecolari e loro potenziale coinvolgimento nella risposta alla terapia con sali di litio tramite analisi dei profili di espressione genome‐wide
… positive clinical response to lithium and valproate treatments in a significant proportion of treated patients. In the present study, we sought to explore whether BD and CH patients responders to lithium share common molecular pathways potentially involved in predisposing to positively …
-
Συναπτική δράση παραγώγων νευροδιαβιβαστών και αντιεπιληπτικών φαρμάκων στον εγκέφαλο φυσιολογικών και επιληπτικών πειραματοζώων
… Carbamazepine, Phénobarbital, Ethosuximide, Valproate and Midazolam). The possibility of their exerting their antiepileptic action through NMDA receptor antagonism was examined. The results suggest that this is unlikely, the exception being Midazolam. The project took place by recording field …
-
The prevalence of and factors associated with antipsychotic polypharmacy in patients with serious mental illness: Findings from a cross-sectional study in a low-middle income country
… likely to have anticholinergic agents and sodium valproate co-prescribed in their treatment regimen. Discussion: The prevalence of APP found in our study is fairly high in comparison with international rates. Antipsychotic prescription patterns reflect a complex interplay among patient, illness …
-
A neural and behavioural investigation of aberrant feeding in animal models of autism spectrum disorder
… the exaggerated neophobic behaviours observed. Valproate (VPA), an anti-epileptic drug and known teratogen, induces an ASD phenotype in offspring when administered during the period of neural tube closure. Specific Aim 4 tested whether rats prenatally exposed to VPA exhibit impaired acquisition …
-
Immunological and biosynthetic studies of the human pyruvate dehydrogenase complex
… with decanoate and dodecanoate as well as valproate and trans-2-nonenoic acid. Interestingly, trans-2-nonenoic acid is a close relative of the major lipid peroxidation product, 4-hydroxynonenal that can be readily converted to 4-hydroxy trans-2-nonenoic acid in vivo. This compound is …
Page 1 of 2