Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"vacuolation"”.
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Vacuolation, proliferation and neoplasia in the liver of Boston Harbor winter flounder (Pseudopleuronectes americanus)
… or were adjacent to neoplastic lesions. Vacuolation, biliary hyperplasia, aggregation of macrophages and necrosis were first seen in two year old fish. These lesions then appeared to progress, becoming more severe and prevalent as the fish grew. Of the fish for which age data were …
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Understanding the molecular mechanism on cell surface receptor interaction of helicobacter pylori vacuolation cytotoxin
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-12-01
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CDDO-ME induces apoptosis in breast cancer cells via Ca2+ influx-mediated dilation of endoplasmic reticulum and c-FLIP downregulation
… 13 2.CDDO-ME induces paraptosis-like cellular vacuolation prior to morphologies features of apoptosis in breast cancer cells 17 3.Ca2+ influx is crucial for CDDO-ME-induced vacuolation and subsequent apoptotic cell death 40 4.Cross-modulation between Ca2+ influx and ROS generation critically …
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Dilations of the Endoplasmic Reticulum Contribute to Spongiform Degeneration and Unlock a Door to a Unified Model of Neuropathological Features in Prion Diseases
… degeneration, which manifests as intracellular vacuolation in neurons, have remained unclear. We considered similarities between the spongiform degeneration in prion diseases and vacuolation in cells exposed to cardiac glycoside (CGs) inhibitors of Na+, K+-ATPases (NKAs). Such similarities were …
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Celastrol induces paraptosis-like cell death via mitochondrial Ca2+ overload in breast cancer cells
… by cycloheximide blocked celastrol-induced vacuolation and subsequent cell death indicating that protein synthesis is required for this process. Generation of reactive oxygen species and mitochondrial Ca²⁺ overload was shown to act as a critical early signal in celastrol-induced …
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Loperamide enhances bortezomib-mediated cell death in colon cancer cells
… is involved in the combined treatment-induced vacuolation 27 3. Combined treatment with loperamide and bortezomib induces ER stress, and CHOP is critically involved in the cell death by loperamide plus bortezomib 33 4. ROS generation is important for the cell death induced by loperamide plus …
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Comparative histology and histochemistry of the vascular system in the White Plymouth Rock hen and the pit fowl hen
… of the elastic lamina and elastica interna, and vacuolation of the tunica intima were observed in association with plaque formation. A 37.5% incidence of abdominal aortic plaques was common to both groups. Brachial arteries were found to have 50% and 16% incidence for pit fowl and White Rock …
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A comparison of the pathological effects on the midgut of the European corn borer treated with Bacillus thuringiensis and Bacillus subtilis
… pathology observed included slight swelling and vacuolation of the epithelial cells, cellular disruption, and complete breakdown of the epithelial tissue and subsequent bacteremia. It was observed that the degree of pathology increased with an increase in the bacterial spore …
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Nutlin-3 sensitizes cancer cells to bortezomib via induction of paraptosis-associated cell death
… of CHOP effectively inhibited the cellular vacuolation and subsequent cell death by the combined treatment, suggesting that upreugulation of CHOP plays an important role in this process. Taken together, our results suggest that MCU-mediated mitochondrial Ca²⁺ overload and CHOP-mediated ER …
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Neuropathologic characterization of a canine model of mucopolysaccharidosis IIIB and additional studies in anti-inflammatory therapy and neuroinflammatory kinetics
… Microscopic pathologic changes include early vacuolation of glial cells at 2 months of age, vacuolation of neurons at 10 months of age, and histochemical staining of storage inclusions as early as 2 months of age. Development of early neuroinflammation was demonstrated via quantitative …
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Helicobacter pylori VacA as a mitochondrial targeted pathogenic effector
… in gastric mucus production, parietal cell vacuolation, and induction of a humoral response to VacA. Altogether, these studies illustrate a model that VacA traffics to mitochondria by endosomes, and upon associating with the mitochondria and inducing dysfunction, a quality control response …
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Multigene Metabolic Engineering Via The Chloroplast Genome
… of the outer wall, enlarged endothecium and vacuolation, decreased the inner space of the locules, affecting pollen grain and resulted in the irregular shape and collapsed phenotype. Reversibility of the male sterility phenotype was achieved by exposing the plants to continuous illumination, …
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Distinct functional effects of NMDA receptors in normal and leukaemic megakaryocytes
… was associated with distinct cytoplasmic vacuolation in both leukaemic and normal cells. This was shown not to be due to apoptosis; the nature and significance of this phenomenon will require further elucidation. In conclusion, functional NMDARs support growth of leukaemic megakaryocytes …
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Comparative analysis of desiccation responses in three Xerophyta species at two stages of seedling development
… ultrastructural changes, such as vacuolation, chloroplast centralization, and starch degradation, typically observed in adult tissues, were also prevalent in the two-leaf seedlings of X. elegans and X. schlechteri. Notably, complete disassembly of the thylakoid membranes was …
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Obesity-Induced Alterations in Sperm Quality, Testicular Morphology, and Extracellular Vesicle Localisation in Male Mice
… (P=0.0011), as well as a high presence of vacuolation and disorganised cellular arrangements. IHC staining showed visible differences in EV localisation between control and obese testes for CD63, CD9 and ANXA1, with IF staining showing a decreased mean fluorescent intensity for CD63 …
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The role of the large T antigen in the in vitro replication of BPyV
… shown to be toxic to cells, with cells showing vacuolation and death. In addition, an individual clone of BPyV was isolated and sequenced. The consensus sequence was translated into amino acid, and several differences observed, one in particular that could affect the replication initiation and …
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<i>Vibrio cholerae</i> non-01 and <i>V. mimicus</i> in diarrhoeal disease : a study of virulence factors
… of strains, was expressed on Vero cells causing vacuolation of cell cytoplasm. Another putative "toxin" found in 19% of strains was demonstrated in a GMI-ELISA. This "toxin" had the ability to bind ganglioside GMI and shared antibody binding sites with CT. <i>V. cholerae</i> non-01 and <i>V. …
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Improvement of the Capripoxvirus, lumpy skin disease virus for use as a vaccine vector
… of CAMs infected with nLSDVdSOD-M showed vacuolation and oedema to a greater degree than nLSDV, Herbivac and nLSDVSODis-M. Herbivac showed greater immune cell infiltration. SOD knock-in, nLSDVSODis-M showed increased epithelial hyperplasia and fibroplasia. Another set of recombinants …
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Mechanistic study on the therapeutic strategy to enhance glioma cell death through inhibition of proteasome and lysosome
Malignant gliomas, the most common brain tumors with high mortality, remain largely incurable despite multimodal treatments including surgical resection, radiotherapy, and chemotherapy. Thus, the researchers are currently attempting to develop novel therapeutic strategies for malignant gliomas. …