Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"vacuolar ATPase"”.
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MODULATING TFEB ACTIVITY IN THE BIRT-HOGG-DUBE' SYNDROME BY TARGETING THE VACUOLAR ATPASE
… top hits were genes encoding subunits of the vacuolar ATPase (V-ATPase). The V-ATPase is a proton-pump protein complex responsible for maintaining the low pH of lysosomes, and it has been described as a positive regulator of mTORC1 signaling, although the exact contribute of the V-ATPase to …
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Regulation Of Inositol Biosynthesis And Cellular Consequences Of Inositol Depletion: Implications For The Mechanism Of Action Of Valproate
… which cannot synthesize inositol, perturbs vacuolar structure, decreases vacuolar ATPase (V-ATPase) proton pumping, and causes partial un-coupling of the V-ATPase. These perturbations were rescued by inositol supplementation. Furthermore, VPA compromised the synthesis of PI3,5P2, which is …
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V-ATPase regulation of Hypoxia Inducible transcription Factors
… Here, I have explored the role of the vacuolar H+-ATPase (V-ATPase), the major proton pump for acidifying intracellular vesicles and facilitating lysosomal degradation, in regulating HIF-$\alpha$ turnover. Unbiased forward genetic screens in near-haploid human cells identified that …