Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"vacuolar ATPase"”.
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Identifying the enzyme involved in Vacuolar ATPase acetylation during doxorubicin-induced cardiotoxicity
… leading to doxorubicin-induced cardiotoxicity. Vacuolar ATPases are a family of electrogenic proton pumps present on the lysosomal membrane that create an acidic environment for proteases to degrade proteins. Our preliminary study found that acetylated Vacuolar ATPase subunit V0 D1 levels …
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MODULATING TFEB ACTIVITY IN THE BIRT-HOGG-DUBE' SYNDROME BY TARGETING THE VACUOLAR ATPASE
… top hits were genes encoding subunits of the vacuolar ATPase (V-ATPase). The V-ATPase is a proton-pump protein complex responsible for maintaining the low pH of lysosomes, and it has been described as a positive regulator of mTORC1 signaling, although the exact contribute of the V-ATPase to …
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Regulation Of Inositol Biosynthesis And Cellular Consequences Of Inositol Depletion: Implications For The Mechanism Of Action Of Valproate
… which cannot synthesize inositol, perturbs vacuolar structure, decreases vacuolar ATPase (V-ATPase) proton pumping, and causes partial un-coupling of the V-ATPase. These perturbations were rescued by inositol supplementation. Furthermore, VPA compromised the synthesis of PI3,5P2, which is …
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V-ATPase regulation of Hypoxia Inducible transcription Factors
… Here, I have explored the role of the vacuolar H+-ATPase (V-ATPase), the major proton pump for acidifying intracellular vesicles and facilitating lysosomal degradation, in regulating HIF-$\alpha$ turnover. Unbiased forward genetic screens in near-haploid human cells identified that …