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Showing 1 to 20 of 77 for “"vaccinia virus"”.
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Vaccinia virus BTB-Kelch proteins
Vaccinia virus (VACV) is a valuable tool to study host-virus interactions and encodes a plethora of immunomodulatory proteins, among which three, A55, C2 and F3, have a BTB/BACK-Kelch (BBK) structure and are the focus of this study. Proteins containing BTB and Kelch domains function as adapters for …
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A role for myotubularins in vaccinia virus egress
Vaccinia virus (VACV) generates multiple distinct forms of infectious virus. Intracellular mature virus (IMV) particles are surrounded by a single lipid membrane and are mostly released upon lysis of the infected cell. Some IMVs are wrapped by an additional double membrane to form intracellular …
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Vaccinia Virus Binding and Infection of Primary Human Leukocytes
Vaccinia virus (VV) is the prototypical member of the orthopoxvirus genus of the Poxviridae family, and is currently being evaluated as a vector for vaccine development and cancer cell-targeting therapy. Despite the importance of studying poxvirus effects on the human immune system, reports of the …
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Exploring antiviral effector cells in vaccinia virus-infected tissues
Vaccinia virus (VACV) is a large, double-stranded DNA virus belonging to the Poxviridae family that was used as the live vaccine leading to the eradication of smallpox. Despite eradication through global vaccination, the precise immune mechanisms underlying recovery from infection are incompletely …
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Viral and cellular proteins involved in vaccinia virus egress
Vaccinia virus (VACV) is a large double-stranded DNA virus with a cytoplasmic site of replication. It has a complex life cycle that produces two distinct infectious virion forms, Intracellular Mature Virions (IMVs) and Extracellular Enveloped Virions (EEVs). The host cell microtubule trafficking …
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The elaborate interplay of natural killer cells and vaccinia virus
Vaccinia virus (VACV) is a poxvirus and is the vaccine used to eradicate smallpox. It is also an expression vector for heterologous antigens and an oncolytic virus for cancer therapy. VACV encodes multiple proteins that aid evasion of the host immune response. There is, however, an incomplete …
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Investigations into the vaccinia virus immunomodulatory proteins C4 and C16
Vaccinia virus (VACV) is the most intensively studied orthopoxvirus and acts as an excellent model to investigate host-pathogen interactions. VACV encodes about 200 proteins, many of which modulate the immune response. This study focusses on two of these: C16 and C4, that share 43.7 % amino acid …
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Applicability of vaccinia virus as cloning and expression vector for bacterial genes: mice immune responses to vaccinia virus expressing Brucella abortus and Listeria monocytogenes antigens
Previous studies by our group showed that vaccinia virus recombinants expressing Brucella abortus (BA) antigens heat shock protein GroEL, 18 kDa protein and Cu/Zn SOD, were unable to induce protective immune responses against Brucella challenge. This dissertation analyzes the possible reasons for …
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Characterization of Vaccinia Virus-Induced Cytotoxic Cells in the Syrian Hamster
… of a T-cell marker, Thy 1.2, on noninduced and vaccinia virus-induced hamster cytotoxic cells was studied utilizing a murine monoclonal anti-mouse Thy 1.2 antiserum ((alpha)-Thy 1.2) which detects a Thy 1.2 homologue on hamster T cells. In the hamster, (alpha)-Thy 1.2 plus complement (C') killed …
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Presentation of Recombinant Proteins in Modified Vaccinia Virus Ankara Extracellular Enveloped Virions
Modified Vaccinia Virus Ankara is a highly attenuated vaccinia virus strain developed during the smallpox eradication campaign. Nowadays recombinant attenuated poxviruses gain importance as live carrier vaccines against different infectious diseases and in cancer therapy. The aim of this work was …
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Autoradiographs Relating Nucleic Acid Metabolism to the Appearance of Intracellular Vaccinia Virus
Made available in DSpace on 2014-12-05T21:45:35Z (GMT). No. of bitstreams: 1 6101664.pdf: 5961925 bytes, checksum: 4dce39cc8b91bef8c1767daf8368b5b9 (MD5) Previous issue date: 1961
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The Vaccinia Virus A56/Vcp Complex: Mechanism of Formation and Implications for Virulence
Vaccinia replication is complex, as it involves both producing new infectious particles as well as a myriad of proteins dedicated to combating the host’s immune response. Although these proteins are often called “non-essential”, they are frequently needed for the virus to achieve maximum virulence …
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Vaccinia Virus-Mediated Glioma Gene Therapy Using p53, IL-2 and IL-12
… attenuated variant of the Lister strain of vaccinia virus (VV) which has been proven to be a safe and effective vaccine vector. Other advantages include a wide host range, a strong promoter system, a high cloning capacity for foreign genes, and a high level of foreign gene expression. The …
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Characterization of the anti-viral effects inhibited by the vaccinia virus K1 protein
Vaccinia virus (VV), a member of the poxvirus family of double-stranded DNA viruses, is well-known as a highly effective vaccine against variola virus, the causative agent of smallpox. Poxviruses encode many strategies to evade the host immune and anti-viral response. One such host anti-viral …
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Mechanisms of Immunogenic Cell Death in Tumour Cells Infected with Oncolytic Vaccinia Virus
Oncolytic viruses (OVs) infect and kill cancer cells whilst generating anti-tumour immune responses. The anti-tumour effect of OVs is attributed to their ability to induce immunogenic cell death (ICD) during their infection of tumour cells. The mechanisms by which ICD occurs is not well defined and …
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In vitro characterization of the antiviral activity of Secomet V against vaccinia virus infections
The anti-poxvirus agent SECOMET V was the reference name for a plant extract produced in a bioreactor from primary plant stem cells, whose antiviral activity has been widely reported in folklore medicine. It exerted its anti-vaccinia virus activity by neutralizing cell-free virus rather than …
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Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia
… of injurious complement components. The vaccinia virus complement control protein (VCP) has the ability to simultaneously inhibit the classical and the alternative complement pathways by binding to the early components C3b and C4b. The complement component C3 is known to be the central …
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Specific Binding Affinity of the Non-Catalytic Domain of Eukaryotic Like Type IB Topoisomerase of vaccinia Virus
… during transcription and replication and. <em>vaccinia</em> and the closely related poxvirus <em>variola</em> virus, at 314 amino acids in length, encode the smallest of the type I topoisomerases(TopIB). TopIB is a two domain protein that recognizes the sequence 5’-T/CCCTT, cleaves at the …
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Characterization of the vaccinia virus M1 protein on caspase inhibition and the MVA/5.2KB virus on immunogenicity
Vaccinia virus (VACV) is a master manipulator of the immune response, and is also a prime candidate for vaccine vectors. This thesis explored both properties through (i) identification and characterization of the VACV M1 protein as a caspase inhibitor and (ii) investigating a previously unexplored …
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An investigation into the specific function of the vaccinia virus 13.8 kDa protein encoded by the N1
Vaccinia virus is the most extensively studied, prototype vertebrate poxvirus, which was used as a vaccine in the eradication of smallpox. The genome of this virus has characteristic variable termini encoding open reading frames that are not essential for virus replication in cell culture. One such …
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