Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"vaccine vector"”.
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Recombinant Lactobacillus as a Vaccine Vector for HIV
… to evaluate the efficacy of Lactobacillus as a vaccine vector against human immunodeficiency virus (HIV) infection. Lactobacillus gasseri, a well characterized commensal of the human intestinal tract, was engineered to express HIV antigens. In this study we have genetically cloned the HIV gag …
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Listeria monocytogenes as a Biologic Vaccine Vector Against Feline Immunodeficiency Virus
… we evaluated a recombinant L. monocytogenes vaccine in an FIV challenge system. In the first study, five cats were immunized with recombinant L. monocytogenes (LMgag/pND14-Lc-env). Control cats were either sham immunized or immunized with wild-type L. monocytogenes (10403S, LM-wt). One year …
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Diagnostic assay and vaccine vector development for African Swine Fever Virus
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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OAdV7, an ovine adenoviral vector as a novel vaccine vector for tumour immunotherapy
… making them one of the most popular viral vectors for vaccine development. To date, the majority of the studies in the literature have focused upon human adenovirus serotype 5 (HAdV5) for the development of adenoviral vectors. However, the use of HAdV5 is limited due to its high prevalence …
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Improvement of the Capripoxvirus, lumpy skin disease virus for use as a vaccine vector
… skin disease virus (LSDV) has been used as a vaccine against LSD. The most successful LSD vaccine is the Neethling vaccine strain (nLSDV) from South Africa. There are however, reports of nLSDV being too attenuated or too virulent in different breeds of cattle. A South African produced vaccine …
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Characterisation of porcine cytomegalovirus and development as a vaccine vector for classical swine fever virus
… and mortality in pigs. Only one compatible vaccine that allows the differentiation between infected and vaccinated animals (DIVA), Suvaxyn® CSF Marker vaccine, is commercially available. However, due to e.g. trading issues caused by vaccination of animals this vaccine is not used …
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Construction of a modified live HP-PRRS virus vaccine and an attenuated listeria vaccine vector using reverse genetics
… genes, studying pathogenesis and developing vaccines. Replication-competent vaccines (e.g., modified live virus (MLV) vaccines and replicating viral/bacterial vectors) are considered the most efficacious approach for vaccine development. We constructed replication-competent candidate vaccines …
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A study of the host-restricted lumpy skin disease virus as a vaccine vector using rabies babies virus as a model
Bibliography: leaves 155-183. Also available online.
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Recombinant Salmonella enterica serovar Typhimurium vaccine vector expressing green fluorescent protein as a model antigen or human immunodeficiency virus type 1 subtype C Gag
Includes bibliographical references (leaves 172-200).
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Development of a conditionally-attenuated cytomegalovirus (CMV) vaccine vector platform, and initial investigations into use of CMV as a vaccine against pandemic influenza A virus
Abstract Cytomegalovirus (CMV)-based vectors are a promising vaccine platform with an ability to induce high levels of durable, immediate, effector memory T (TEM) cell responses against their heterologous encoded pathogen target antigen. The primary focus of this thesis is centered on a hypothesis …
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The development of penguinpox virus (PEPV) as a vaccine vector : transfer vector construction and rescue of virus growth in rabbit kidney cells (RK-13) by vaccinia virus K1
Of the many vaccine trials which have taken place, the most promising results have been obtained from the recent phase 3 clinical trial which tested the ability of a dual protein and Canarypox virus recombinant to protect humans against HIV-1 infections. Because poxviruses are being developed as …
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HIV prophylaxis: an essential role for T cells and adjuvants in recombinant mucosal Lactobacillus acidophilus vaccines
Current HIV vaccines have poor efficacy, with inconsistent levels of protection following mucosal HIV exposure. Lactic acid bacteria offer an alternative vaccine vector targeting the primary site of HIV infection, the mucosa. In these studies we evaluated the immunogenicity of several strains of …
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Construction and evaluation of three candidate vaccines expressing HIV-1 subtype-C mosaic Gag
… makes it challenging to develop effective vaccines that target a wide range of HIV subtypes. Mosaic immunogens have been computationally designed to specifically overcome this hurdle by maximizing the inclusion of common T cell epitopes. When compared to consensus immunogens, polyvalent …
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Development of new tools for the production of plasmid DNA biopharmaceuticals
DNA vaccines and gene therapies that use plasmid DNA (pDNA) as a vector have gained attention in recent years for their good safety profile, ease of manufacturing, and potential to treat a host of diseases. With this interest comes increased demand for high-yield manufacturing processes. Overall, …
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The construction and characterization of recombinant sindbis virus vectors as a platform for anthrax vaccine development
… to protect against B. anthracis. Anthrax Vaccine Adsorbed (AVA) is the only licensed vaccine preparation currently used however, immunogenicity is variable and the boosting regimen is long-term and must be maintained to ensure continued protection. Protective antigen (PA), the chief …
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Investigation of Vesicular Stomatitis Virus Interaction with Host Cell Proteins and Associated mRNA Structures
… VSV has also proven to be an effective vaccine vector and oncolytic therapy agent. For these reasons, the interaction between VSV and host cells in the context of infection and innate immunity was of great interest. Previous work performed by the laboratory of Douglas Lyles determined …
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Generation of a FHV-1 Viral Vaccine Against Gonadotropin Releasing Hormone for Immunocontraception of Felines
… this research is to develop a safe contraceptive vaccine that could be delivered to the feral cat population in bait without compromising non-feline species. Feline Herpes Virus (FHV) is a feline specific virus. The USDA has approved the immunization of cats with an attenuated, non-pathogenic …
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Determining the Innate and Adaptive Immune Responses to Vesicular Stomatitis Virus Vaccine Vectors
Vesicular stomatitis virus (VSV) vaccine vectors have been engineered to express many different antigens. Studies in mice and nonhuman primates have demonstrated efficacy against several pathogens. A novel strategy to enhance VSV as an effective vaccine is to engineer vectors that induce innate …
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A Recombinant Vesicular Stomatitis Virus Expressing the Junin Virus Glycoprotein for Arenavirus Countermeasure Development
… First, we evaluated rVSVΔG-JUNVGP as a vaccine against lethal Junin virus (JUNV) challenge in a guinea pig model. Currently, there are no JUNV vaccines licensed by the United States Food and Drug Administration (FDA) for at-risk individuals. We demonstrated that rVSVΔG-JUNVGP generated …
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