Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"vaccine escape"”.
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Population dynamics of infectious disease and pathogen evolution: modelling vaccine escape
… focussing on the selection pressure for immune escape. We study the qualitative patterns of this escape pressure — as a function of the vaccination coverage — and the epidemiological impact thereof, taking analytical approaches wherever possible. Chapter 2 varies the balance of the contributions …
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Responding to an Evolving Pandemic: Characterisation of Emerging Evolving Viruses and Population Immunity by the Example of SARS-CoV-2
… the achievement of protection with the original vaccine designed against the ancestral Wuhan strain to a time when vaccine strain updates became standard practice for SARS-CoV-2. Antigenic cartography is an integral tool for influenza virus characterisation and vaccine strain selection. In this …
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Investigation of the role of a large serine rich repeat protein in Streptococcus pneumoniae
… the prevalence of antibiotic resistance and vaccine escape is increasing. The pneumococcus causes a wide range of diseases, and this can be attributed to both the succeptibility of the human host and the genetic background of the infecting strain. The study of the contribution of variations …
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Interpretations of Machine Learning and Their Application to Therapeutic Design
… design, including a pan-variant COVID-19 vaccine. While ML models are widely deployed and often attain superior accuracy compared to traditional approaches, deep learning models are functionally complex and difficult to interpret, limiting their adoption in high-stakes environments. In …
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Bacterial colonization of the nasopharynx in paediatric patients with acute respiratory viral symptoms
… introduces selection pressures against those vaccine strains. This will likely alter colonization dynamics, with perhaps serotype replacement or the emergence of vaccine escape mutants. Evidence to date suggests that vaccine serotypes have been partially displaced, and that some non-vaccine …
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Exploring the Population Structure, Recombination Landscape, and Pan-Genome of the Global Neisseria meningitidis Population
… disease is vaccination. Currently, available vaccines target five of the extant serogroups of N. meningitidis, chosen through study of the serogroups most frequently found in disease. However, either the replacement of disease lineages with those of different serogroups or capsular switching …