Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 69 for “"vaccine design"”.
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Data-driven strategies for vaccine design
… with the same pathogen. Until recently, vaccine development has largely followed empirical paradigms that have proven successful against many diseases. However, many pathogens have now evolved that defy success using the traditional approaches. Rational design of vaccines against such …
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Neutralizing antibody responses in HIV dual infection: lessons for vaccine design
… of a safe, effective prophylactic HIV vaccine remains a major global health priority. Stabilized, soluble trimers that mimic the native functional HIV trimer have been developed that elicit strain-specific neutralizing HIV antibodies in animal models, and are currently being evaluated …
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Neutralizing antibody responses in HIV-1 dual infection : lessons for vaccine design
Includes abstract. Includes bibliographical references.
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A Tet-repressible regulation system in mycobacteria for application to vaccine design
Includes abstract. Includes bibliographical references (leaves 116-123).
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An investigation into improved HIV-1 subtype C envelope based vaccine design
Includes abstract. Includes bibliographical references.
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In silico vaccine design for hepatitis C: A computational platform for fighting disease
… have effective treatments been developed and a vaccine remains elusive. The high cost of efficacious drug treatments severely limits their impact in the developing world, leaving prophylactic vaccination the best hope for global control. The high mutation rate of HCV coupled with its rapid …
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Molecular modeling studies of carbohydrate vaccine antigens: informing the future of vaccine design
… into the intricate world of carbohydrate-based vaccine antigens by employing molecular dynamics simulations to explore the link between their structure, conformation, and immune function. Through a series of four case studies focused on distinct antigen targets, this research aims to predict …
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Candidate Bivalent HCV Vaccine: A Novel Approach To Vaccine Design for Hyper-variable Viruses
… underscores the urgent need for a prophylactic vaccine. Vaccine development has faltered because the extreme genetic diversity of the virus has precluded the induction of broadly protective antibodies (AB) with classical vaccines. Here, I describe a novel approach to vaccine design for …
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PCP and conformational motifs: applications in predicting mechanical strength, allergenicity of proteins and vaccine design
… folding process, and aids in the rational design of new therapeutic drugs and vaccines. In my research, I finished three projects where I identified specific motifs based on the conservation of Physical–Chemical Properties (PCP) of amino acids that could be related to the mechanical …
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Combating Plague: Fighting a War on Two Fronts Through Vaccine Design and New Therapeutic Intervention
… to occur annually. With no FDA-approved vaccine and therapeutics limited to antibiotics, there is an imperative need to develop new prophylactics as well as therapeutics against plague infection. Identification of new virulence factors of Y. pestis and understanding their role during the …
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Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design
… to be crucial for developing an effective vaccine. The Membrane Proximal External Region (MPER) within the HIV- 1 gp41 envelope is a promising vaccine target. The MPER is highly conserved, functionally constrained, facilitates virus fusion and is targeted by broadly neutralizing monoclonal …
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Human immunodeficiency virus type-1 distribution in South Africa and the relevance of genetic diversity on vaccine design
… (7.2%). It may thus be beneficial if a HIV vaccine for South Africa is based on a subtype C model. In addition, a rapid method for identification of HIV-1 gag subtypes was developed based on restriction fragment length polymorphism (RFLP) analysis of 400bp (p17) or 650bp (p17 and 5' p24) …
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Investigating cross-clade immune responses in HIV-1 subtype C-infected individuals from South Africa: implications for HIV vaccine design
Background An effective HIV vaccine remains the main hope for controlling the HIV epidemic and is a global health priority. The genetic diversity of the virus across the globe is a major impediment to developing an effective vaccine. Whether a universal vaccine is possible still remain elusive. …
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Creating a New Malaria Vaccine Design that uses a Blood Stage P. falciparum Chassis for Non-Blood Stage Antigen Presentation
… results in increasing drug resistance and poor vaccine efficacy. Current vaccine designs focus on a single stage in the parasite life cycle and antibody responses are inefficient in offering protection, leading to “malaria rebound” as a lack of immune response to multiple stages of the life …
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Refinement of the Computational Vaccine Optimization Framework (OptiVax) through the development and analysis of a better algorithm for vaccine design choice
… the maximum 𝑛- times coverage problem to epitope vaccine design (OptiVax) and compare various vaccine designs both found in the literature and produced by the three aforementioned algorithms.
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Engineering Nanoparticulate Antigens for Enhanced Follicular Accumulation and Immunogenicity
In vaccine design, antigens are often arrayed in a multivalent nanoparticle form, but in vivo mechanisms underlying the enhanced immunity elicited by such vaccines remain poorly understood. In this thesis, we began by examining two model, HIV-immunogen-bearing nanoparticles that displayed an …
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Finding all maximal common substructures in proteins
… relationship and application in drug and vaccine design. Unlikethe structural alignment problem, a good solution for the common substructureidentification problem should produce results that include:1. All possible common substructures (CS),2. CSs whose elements do not follow the same …
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An integrated approach to enable rapid scalable upstream production of subunit vaccines with Pichia pastoris (Komagataella phaffii)
… COVID-19 pandemic motivates the development of vaccine designs and manufacturing technologies tailored to enable widespread access in low- and middle-income countries (LMICs). Due to limited supply, vaccines targeting SARS-CoV-2 were initially distributed primarily to high-income countries. The …
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Optimizing vaccine dosing kinetics for stronger antibody response
One of the barriers to rational vaccine design against evolving pathogens is our lack of mechanistic understanding of how innate and adaptive immune response systematically emerge and evolve. Immune response is comprised of dynamic events that require many components to cooperate collectively in a …
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HIV subtype C diversity: analysis of the relationship of sequence diversity to proposed epitope locations
… HIVNET, Network for Prevention Trials cohort for vaccine development. HIVÂ’s biology and rapid mutation rate have made vaccine design difficult. We examined HIV-1 subtype C diversity and how it relates to CTL epitope location along viral gag sequences. We found a negative correlation between codon …
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