Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"vaccine adjuvant"”.
-
EVALUATION OF ALPHA-D-GLUCAN NANOPARTICLE AS A VACCINE ADJUVANT
The use of nanoparticles for delivery of vaccine antigens and as vaccine adjuvants is appealing because their size allows efficient uptake by dendritic cells and their biological properties can be tailored to the desired function. Here, we evaluated the potential of dendrimer-like α-D-glucan …
-
Cytokine-bearing Influenza Vaccine: Adjuvant Potential of Membrane-bound Immunomodulators
… a much improved, more sophisticated influenza vaccine. Our group has developed an in vitro model system for producing a membrane-bound Cytokine-bearing Influenza Vaccine (CYT-IVAC). Numerous cytokines are involved in directing both innate and adaptive immunity and it is our goal to utilize the …
-
Expression strategies for plant-based production of a vaccine adjuvant
Today's development of novel vaccines stresses the need for edible vaccines that are inexpensive, easily administered and capable of being stored and transported without refrigeration. Without these characteristics, developing countries find it difficult to adopt vaccination as the central strategy …
-
Development of a Novel Vaccine Adjuvant and Delivery System for Cancer and Influenza
<p>Vaccines often require addition of adjuvants to boost the potency and longevity of antigen specific immune responses. At present, there is a scarcity of safe vaccine adjuvants and delivery systems that can stimulate both cellular (Th1) and humoral (Th2) immune response. Such adjuvants are …
-
Incorporation of CpG Oligodeoxynucleotides into α2-Macroglobulin: Development of a Novel Vaccine Adjuvant Delivery Mechanism
… are being clinically evaluated as treatments and vaccine adjuvants for infectious diseases, cancer, and allergic disorders. α2-Macroglobulin (α2M) is a human plasma protein that binds and modulates the activity of a variety of cytokines, growth factors, enzymes, and antigens. Upon proteolytic …
-
Development of a Novel Vaccine Adjuvant System Utilizing an In Situ Implant System to Modified Release
<p>Pulsatile release formulations for single dose vaccines have been studied for many years because of the advantages that they may provide to vaccine administration with a single dose instead of prime and booster shots.</p> <p>The aim of this work is to develop novel formulations based on an In …
-
Use of Cholera Toxin B as a Vaccine Adjuvant Activates Antigen Presenting Cells and Stimulates Production of Pro-Inflammatory Cytokines
… Disease Control. To date, there is no approved vaccine to provide protection against this pathogen. Previous <em>in vivo </em>studies with mice<em> </em>have shown that a mucosally targeted vaccine preparation of inactivated <em>F. tularensis</em> (<em>iFt</em>) adjuvanted with Cholera toxin “B” …
-
Peptide Vaccine Formulation Controls The Duration of Antigen Presentation and Magnitude of Tumor‐Specific Cd8+ T Cell Response
… progresses in vaccinology, therapeutic cancer vaccines have not achieved their full potential. We previously showed that the duration of antigen presentation critically affected the quantity and quality of T cell response and subsequent anti‐tumor efficacy. Here we describe L‐tyrosine amino …
-
Determining the Innate and Adaptive Immune Responses to Vesicular Stomatitis Virus Vaccine Vectors
Vesicular stomatitis virus (VSV) vaccine vectors have been engineered to express many different antigens. Studies in mice and nonhuman primates have demonstrated efficacy against several pathogens. A novel strategy to enhance VSV as an effective vaccine is to engineer vectors that induce innate …
-
A materials-based approach for localized delivery of cancer immunotherapy
… with pSer tags bind tightly to the common vaccine adjuvant aluminum hydroxide (alum) via ligand exchange. Intratumoral injection of pSer-cytokine-loaded alum led to prolonged retention of the proteins in tumors (>weeks) with minimal side effects. A single dose of alum-tethered …
-
SYNTHESIS AND STRUCTURAL DESIGN OF CARBOHYDRATE-BASED ARCHITECTURES: FROM VACCINE ADJUVANTS TO GLYCAN FOLDAMERS
… and synthesis of glycomimetics structures3, vaccine adjuvants4. Polyglycan structures have been used both for biology and for material chemistry purpose5. The first chapter of this PhD thesis focus the attention on vaccine adjuvant semi-synthesis. Vaccines are one of the oldest treatments in …
-
The effects of topical calcipotriol treatment on immune responses to vaccination
… shown to promote mucosal immunity when used as a vaccine adjuvant. We show here that pretreatment of an area of skin with the synthetic vitamin D analog calcipotriol combined with transcutaneous immunization results in the induction of CD4⁺CD25⁺ Tregs capable of inhibiting the elicitation of a …
-
THE ACTIVATION, RECEPTOR COMPLEXING AND ENDOGENOUS REGULATION OF THE TYPE-I INTERFERON RESPONSE AS IT PERTAINS TO INNATE IMMUNITY
… immune response. First, investigations into the adjuvant potential of dsRNA reveal that a 139bp dsRNA molecule is a viable candidate for vaccine adjuvant studies. Next, structural and functional studies of TLR3 with neutralizing antibodies provide evidence for a new TLR-signaling model in which …
-
Mechanisms of Immuno-Modulation With The TLR4 Agonist Monophosphoryl Lipid A in the Treatment of Sepsis
… 4 agonist that has been approved for use as a vaccine adjuvant in humans. In these studies, we evaluated the effect of MPLA treatment on the innate immune response to systemic infection in mice with emphasis on bacterial clearance, leukocyte recruitment and function, as well as potential …
-
Design of vaccine nanotechnology-based delivery systems, the effect of CpGODN TLR9 agonist-protein antigen conjugates anchored to liposomes
… Although CpGODN has shown promising results as vaccine adjuvant in preclinical and clinical studies, its in vivo stability and potential systemic toxicity have generated concern for the use of CpGODN. In an effort to increase stability, localise action and reduce dosage, different strategies …
-
Modulation of Allergic Disease through the use of Th1-associated Vaccine Adjuvants
… The purpose of this work was to identify a vaccine adjuvant that induced potent antigen-specific Th1 immune responses and determine its ability to reduce the development and severity of Th2- mediated allergic disease, using models of peanut hypersensitivity.</p><p>Three studies were …
-
A study of the biological activity of bee venom and its fractions with regard to cosmetic science and immunology
… use in skin anti-ageing applications and as a vaccine adjuvant, respectively. BV fractions were obtained by reversed phase preparative chromatography and characterised by LC-MS and NMR techniques. The fractions were assayed for antimicrobial and cytotoxic activities against a range of microbes …
-
Exploration of Toll-like Receptor 7 and 8 Agonists as Potential Vaccine Adjuvants
… TLR7/8 agonists hold promise as potential vaccine adjuvants, since they directly activate antigen-presenting cells and enhance T helper 1-driven immune responses. A general introduction to TLRs, with an emphasis on the role of TLR7/8 activation in innate and adaptive immune responses is …
-
Antibody-omics for biomarker discovery in vaccinology and infectious diseases
… by neutralizing toxins, thereby modulating vaccine response and disease outcome. Their protective effector functions are primarily regulated by the antigen-binding domain (Fab) and the crystallizable domain (Fc). While traditional methods of antibody profiling have successfully applied …
-
Modulation of the immune response by current and novel treatments for hepatitis C virus
… to boost antigen specific responses or as a vaccine adjuvant.<br/>SM-360320 was shown to enhance viral clearance and immune modulation with induction of 2’5’OAS gene expression, inhibition of replication of HCV replicons in Huh 7 cells, enhanced secretion of anti-viral and pro-inflammatory …
Page 1 of 2