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Showing 1 to 20 of 51 for “"vWF"”.
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Understanding the Role of von Willebrand Factor (VWF) in Angiogenesis and Angiodysplasia
von Willebrand factor (VWF) is a large multimeric glycoprotein essential for hemostasis, mediating platelet adhesion to sites of vascular injury and stabilizing coagulation factor VIII (FVIII) in circulation. Deficiency or dysfunction of VWF results in von Willebrand disease (VWD), the most common …
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A genome-wide association study in chronic thromboembolic pulmonary hypertension and the ADAMTS13-VWF axis
… variation in plasma von Willebrand factor (VWF) levels. Abnormalities in haemostasis are implicated in CTEPH pathobiology, including elevated levels of VWF, which is cleaved by ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13). The ADAMTS13-VWF axis …
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von Willebrand factor interaction with subendothelial collagens and platelet surface receptor GPIBalpha under shear conditions
… platelet surface receptors GPIbalpha, multimeric vWf acts as a bridge between subendothelium and circulating platelets. In this study, the molecular binding between vWf multimers and human pepsin-digested collagen I, III and VI was characterized using Surface Plasmon Resonance (BIAcore). Compared …
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A Microfluidic Approach For Investigating The Role Of Blood Flow In Thrombosis
… rates to aggregate von Willebrand factor (VWF) into insoluble fibers held in place by a micropost. VWF fibers were non-amyloid and resistant to ADAMTS13 and tissue plasminogen activator. Factors XIIa and XIa were captured in VWF fibers during aggregation, and could initiate fibrin formation …
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Characterization of platelet glycoprotein Ib-IX-V: von Willebrand factor interaction under shear conditions
… glycoprotein (GP) Ib and von Willebrand factor (VWF). In the first part of the work, we evaluated the kinetics of interaction between platelet GP Ib-IX-V complex and VWF under arterial flow conditions. The GP Ibalpha subunit of GP Ib complex binds to VWF through the Al domain of VWF. Impaired GP …
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Aberrant and Alternative Splicing of von Willebrand Factor
… or qualitative defects of von Willebrand factor (VWF). VWD can be caused by a variety of mutations throughout the VWF gene, the majority of which are missense changes. Approximately 10% of pathologic VWF mutations are thought to disrupt the process of VWF splicing leading to VWD; however, this …
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The Role of YAP/TAZ in von Willebrand Factor Gene Expression
von Willebrand Factor (VWF) is a large multimeric glycoprotein with important procoagulant roles in the circulation, including mediating platelet adhesion at sites of vascular injury and stabilizing Factor VIII in the plasma. VWF expression and activity is critically regulated to protect against …
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Interaction Between the Metalloprotease ADAMTS-13 and the Proteins of the Alternative Pathway of the Complement System
Von Willebrand factor (VWF), a multimeric protein that has a central role in hemostasis, has been shown to interact with complement components. However results are contrasting and inconclusive. By studying 20 patients with congenital thrombotic thrombocytopenic purpura (cTTP) who can not cleave VWF …
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Determination of ADAMTS13 Susceptibility in Type IIA von Willebrand Disease
… caused by a deficiency in von Willebrand Factor (vWF), a large glycoprotein that assists in coagulation. Specifically, large vWF multimers in the blood stream are key components in starting the coagulation cascade. vWF is cleaved by the metalloprotease ADAMTS13, regulating the multimers size, …
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VON WILLEBRAND DISEASE: NEW INSIGHTS INTO THE EPIDEMIOLOGY, PATHOPHYSIOLOGY AND GENOTYPE/PHENOTYPE CORRELATION
… della glicoproteina fattore di von Willebrand (VWF). Questa tesi mirava a fornire nuove informazioni sull'epidemiologia, la fisiopatologia e il genotipo/fenotipo della VWD. Abbiamo condotto 5 studi per affrontare questi obiettivi. (i) Analizzando i dati dell'esoma e del genoma di 141.456 …
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Effect of Levothyroxine Administration on Hemostatic Analytes in Doberman Pinschers with von Willebrand's Disease
… increases plasma von Willebrand factor (vWf) concentration and enhances vWf function. The effects of levothyroxine administration were evaluated in 8 euthyroid Doberman Pinschers with plasma vWf concentration <30%. Levothyroxine (0.04mg/kg PO q12hours) and placebo were administered for 30 …
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PATHOPHYSIOLOGY OF VON WILLEBRAND FACTOR IN BLEEDING AND THROMBOSIS
von Willebrand factor (VWF) is a multimeric glycoprotein mainly known to be involved in primary hemostasis recruiting platelets at the site of damaged vessels and acting as factor VIII (FVIII) carrier. Quantitative or qualitative alteration of VWF protein is responsible for von Willebrand disease …
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Multi-scale computational modeling of particle adhesion dynamics under shear flow
… description of the von Willebrand factor (VWF) mediated thrombus growth process was formulated. The physics-based model captures distinct stages of the thrombus growth process in shear-induced platelet adhesion (SIPA) and platelet-aggregate morphology. It describes platelets dynamics, VWF …
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The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke.
… adults. High levels of von Willebrand factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF multimers into smaller …
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CLINICAL AND LABORATORY CHARACTERISATION OF ACQUIRED VON WILLEBRAND SYNDROME
… disorder due to reduced or dysfunctional VWF in individuals without a personal or familial bleeding history. It is associated with systemic diseases such as lymphoproliferative (LPDs) and myeloproliferative neoplasms (MPNs), cardiovascular, and autoimmune conditions. The underlying …
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Role of von Willebrand factor in shear induced platelet accumulation in a microfluidic device
… via the glycoprotein von Willebrand factor (vWF). To investigate the relative contributions of vWF and platelets in high shear thrombosis, the present work developed a microfluidic thrombosis assay to meet low blood volume requirements and fluid shear conditions (3500-6000 s-1). Microfluidic …
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Vibration-induced white finger in dockyard employees
Vibration-induced white finger (VWF) is a vascular condition associated with occupational exposure to hand-transmitted vibration. The fingers are prone to intermittent blanching attacks which may be triggered by cold conditions and are usually accompanied by numbness and tingling or pain. VWF has …
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Genetic characterization of families with von Willebrand disease
… defects of the von Willebrand factor (VWF). The severity of the disease can vary considerably, as can the hereditary patterns. The variable phenotypes of VWD have given rise to a classification scheme that divides the disease into three types according to how it is manifested and …
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Die Wirkung von niedrig dosiertem Desmopressin auf die durch Acetylsalicylsäure verlängerte Blutungszeit
… von FVIII und den von Willebrand-Faktor (vWF) ist lange bekannt und gut untersucht. Zur Erklärung dieser Beobachtung wird meist die plättchenadhäsive Wirkung des vWF genannt. Obwohl die Bedeutung der vor¬liegenden Daten zur vWF-/FVIII-Freisetzung für die Therapie von Plättchenstörungen …
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