Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"v&beta"”.
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Alpha v beta 5 and related receptors in human B lymphocyte development
CD23 is a multi-functional protein which exists in membrane-bound and soluble forms. Its functions include acting as the low affinity receptor for IgE and generating pro-inflammatory cytokine release in monocytes. CD23 has been found to interact with αvβ5 and this interaction greatly enhances …
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Identification and functional characterization of novel receptor ligands of CD40 and alpha(v) beta(3) integrin: implications for gene delivery
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Microbiology and Immunology, 2002.
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Chemomechanical regulation of integrin activation and cellular processes in acidic extracellular pH
… activation and binding of integrin [alpha]v[beta]3, and to characterize the consequences for downstream subcellular- and cellular-scale processes. Molecular dynamics simulations demonstrate that opening of the integrin [alpha]v[beta]3 headpiece occurs more frequently in acidic pHe than in …
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Characterization of a T Cell Receptor: Peptide/MHC Binding Interaction
… (CDR) and fourth hypervariable region of the $\beta$ chain. Using these mutant scTCRs, we have identified V$\beta$ residues which are energetically important in the interaction of the 2C TCR with the anti-V$\beta$8 mAb F23.2, the anti-clonotypic mAb 1B2, and the peptide/MHC ligand …
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Progression of chondrocyte signaling responses to mechanical stimulation in 3-D gel culture
… At early days in culture, blocking [alpha]v[beta]3 integrin abolished dynamic compression stimulation of proteoglycan synthesis, independent of effects in free-swell culture, while blocking [alpha]5[beta]1 integrins abolished the effect of compression only when blocking in free-swell …
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The Role of Epigenetics in Regulating V(D)J Recombination and Allelic Exclusion
… force RSS accessibility in DP thymocytes, but Vβ RSS accessibility did not overcome additional mechanisms involved in allelic exclusion. One potential mechanism that has been suggested in the literature is changes in locus conformation. Thus, we tested if RSS accessibility and locus …
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Peptide Targeted Drug Delivery to Non-Small Cell Lung Cancer
… for the delivery of therapeutics to alpha(v)beta(6)-positive NSCLC tumors. To examine the ability of the H2009.1 peptide to specifically deliver drugs to NSCLC cells, it was used as a targeting ligand for three different drug platforms: liposomal doxorubicin and direct drug conjugates of both …
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T-Lymphozyten aus Nabelschnurblut tragen den Killer cell Lektin-like Receptor G1 (KLRG1) : eine phänotypische und funktionelle Charakterisierung
… des Nabelschnurblutes zu klären: Das V-beta-Repertoire aller T-Zellen des Nabelschnurblutes war polyklonal, was darauf hindeutet, dass sowohl die KLRG1+ als auch die KLRG1- Population aus einer Vielfalt von T-Zellklonen entstanden war. Außerdem zeigte die Analyse des TREC "T cell …
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The Roles of Rap1 in Cancer Metastasis and Pancreatic Islet Beta Cell Function
… Epac, are important regulators of pancreatic β-cell insulin secretion. However, the role of Rap1 in β-cell biology has not yet been defined. Here we established roles for Rap1 in distinct signaling events and begin to answer some of the key questions about Rap1 function in two diverse …
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Decay of correlations and inference in graphical models
… each vertex v is at least [alpha][delta](v) + [beta] where [delta](v) is the degree of vertex v and [beta] is a constant that only depends on [alpha]. The result is obtained by proving the decay of correlations of marginal probabilities associated with the vertices of the graph measured using a …
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Analysis of Β8 Integrin In Neurogenesis and Neurovascular Homeostasis
Neurogenesis in the adult mouse brain occurs within the subventricular zone (SVZ) of the lateral ventricle. In the SVZ, neural stem cells (NSC) reside in a specialized microenvironment, or vascular niche, consisting of blood vessels and their basement membranes. Most NSCs in the SVZ differentiate …
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Structually diverse Cu-64-labeled RGD peptide conjugates for PET imaging of αvβ3 expression
… the development of integrin α<sub>v</sub>β<sub>3</sub>-targeting radiopharmaceuticals for medical imaging applications from the perspective of both the radiometal-labeled chelator as well as the targeting peptide. Several macrocyclic copper(II) chelators have been studied with the goal …
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How CD4+ T Cells Recognize Allostimulatory Peptide-MHC
… molecule, I-E<super>b</super>. The naive TCR Vβ repertoire was altered in B6.E+ thymi and spleens, suggesting a potential for mediating different outcomes in T cell reactivity. In alloreactivity, the B6.E+ T cell response was significantly dampened. We wondered if similar effects would be …