Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"uveal melanoma"”.
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microRNAs in Uveal Melanoma: in vivo findings and computational analysis
Background: Uveal melanoma (UM) is the most prominent primary eye cancer in adults, featuring a high mortality rate and poor prognosis. The role of miRNAs as potential biomarkers in UM patients has drown increasing attention and recent computational analyses have shown the prognostic significance …
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YAP and TAZ have Functionally Redundant Roles in Uveal Melanoma
Uveal Melanoma (UM) is the primary ocular malignancy in adults. The primary tumor is treatable but 50% of patients develop fatal metastases. Most UM are driven by activating mutations in the heterotrimeric G protein alpha subunits paralogs, GNAQ or GNA11, whose main downstream effectors are MAPK …
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Establishment of MITF and TAZ as major determinants of uveal melanoma
Uveal melanoma (UM) is a cancer that arises from transformed melanocytes that exist in the uvea of the eye. Although UM is relatively rare, it is extremely deadly, due to the lack of treatment options for the metastatic disease. In contrast, cutaneous melanoma (CM), which is derived from …
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The Dark Side of the Eye: Towards Robust Deep Learning Models for Uveal Melanoma Screening
UM (Uveal Melanoma) is a rare but highly aggressive cancer, characterized by high metastatic risk and a poor prognosis if not treated in time. Early detection is challenging, as this lesion presents overlapping features with benign ones, which can lead to misdiagnosis. A late diagnosis often …
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Oncogenic mutation of GNAQ/11 disrupts melanocyte biology in a Zebrafish model of uveal melanoma
Uveal melanoma (UM) is the most common primary intraocular cancer in humans. These tumors arise from nonclassical melanocytes found in the choroid, iris, and ciliary body (collectively called the uvea). Over 80% of UM tumors contain activating mutations in one of two genes encoding the homologous …
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Genetic markers in circulating tumour cells as a measure of the metastatic propensity of uveal melanoma
Background: Uveal melanoma (UM) is an extremely aggressive disease with approximately 50% of patients developing incurable metastatic disease. Therefore, accurate prognosis of a patient is necessary for closer follow up and the earlier implementation of systemic adjuvant therapies in those most …
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A GNAQ/11-driven zebrafish cancer model identifies MITF and YAP as key determinants for uveal melanoma
Uveal melanoma (UM) is a cancer of eye melanocytes that has a particularly poor prognosis and a dearth of treatment options. In contrast to cutaneous melanoma (CM), which is driven by oncogenic mutation of BRAF or NRAS, UM is driven by oncogenic mutations in GNAQ or GNA11 (>80% of patients). We …
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Biased Constitutive Activity in the Uveal Melanoma Oncogene CYSLTR2 is Unique in CYSLTR2 Germline and Pan-Cancer Human Variome
<p>Uveal melanoma is the most common eye cancer in adults and is clinically and genetically distinct from skin cutaneous melanoma. In a subset of cases, the oncogenic driver is an activating mutation in CYSLTR2, the gene encoding the G protein-coupled receptor (GPCR) cysteinylleukotriene receptor …
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The Role of Ribosomal Maturation Proteins WBSCR22 and EMG1 Methyltransferase Activity in Cancer
… reported in acute myeloid leukaemia (AML) and uveal melanoma (UVM), where it strongly correlates with poor prognosis. However, the specific role of these enzymes in cancer is still unknown. I identified both WBSCR22 and EMG1 catalytic activity as essential for the growth of AML and UVM cells …
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A Contemporary Appraisal of Ocular Melanoma in New Zealand (Aotearoa)
… represents a contemporary appraisal of ocular melanoma in New Zealand (Aotearoa), providing fundamental knowledge on uveal and conjunctival melanoma in a population with an exceptionally high burden of cutaneous melanoma. Seven nationwide studies, both prospective and retrospective, spanning 21 …
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The Role of NKT Cells in Immune Evasion of Liver Metastases Arising from Intraocular Tumors
Uveal melanoma (UM) is the most common intraocular tumor in adults and liver metastasis is the leading cause of death in UM patients. We have previously shown that NKT cell-deficient mice develop significantly fewer liver metastases from intraocular melanomas than do wild-type (WT) mice. Here, we …
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Induced Degradation of G-Protein-Coupled Receptors Through Proteolysis Targeting Chimeras
… receptor 2 (CysLTR2), which is associated with uveal melanoma (UM). UM is an eye cancer that develops in melanocytes with high mortality rates due to high incidence of metastasis. In a subset of cases, the oncogenic driver is the activating mutation in the gene CYSLTR2, which encodes a …
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Identificazione delle alterazioni epigenetiche indotte dall'esposizione ai pesticidi e validazione del potenziale diagnostico e prognostico dei microRNA nel melanoma uveale
… livelli di espressione dei miRNA osservati nel melanoma uveale al fine di identificare un pannello di fattori genetici ed epigenetici marcatori da utilizzare per monitorare lo stato di salute degli individui professionalmente esposti a questi contaminanti e quindi prevedere il rischio di …
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Identifying the basis for anticancer synergy with PAC-1, with applications to meningioma
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Ligandi ibridi Sigma-HDAC come potenziale trattamento terapeutico per il melanoma uveale: design, sintesi e valutazione biologica
… con efficacia terapeutica nei confronti del melanoma uveale, un tumore intraoculare tanto raro quanto aggressivo. Il lavoro è stato condotto presso il Dipartimento di Scienze del Farmaco e della Salute (Università degli Studi di Catania), presso il Departamento de Quimica Organica …
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Design and synthesis of small molecules for oncological and neurodegenerative diseases with multitarget properties [Progettazione e sintesi di piccole molecole con proprietà multitarget per malattie oncologiche e neurodegenerative]
Questa ricerca di dottorato affronta l’esigenza urgente di strategie terapeutiche innovative contro malattie complesse come il cancro e i disturbi neurodegenerativi, in cui i farmaci a singolo bersaglio spesso falliscono a causa della patogenesi multifattoriale e della resistenza ai farmaci. Il …