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Showing 1 to 8 of 8 for “"us28"”.
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Understanding and Exploiting Viral Protein US28 During Human Cytomegalovirus Latency
… including the viral G-protein coupled receptor US28. Here, I explore mechanisms by which US28 optimises host cells for latent carriage. Using an unbiased proteomic screen, I have assessed changes in total host proteins induced by US28 and find that interferon-inducible genes are downregulated by …
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CHARACTERIZATION OF HCMV-ENCODED CHEMOKINE RECEPTOR US28 TRANSDUCED MSU1.1 HUMAN FIBROBLAST CELLS
… (HCMV) encodes the G-protein coupled receptor US28. Using a mouse model system, US28 was previously found to be oncomodulatory, increasing proliferation, inducing anchorage independent growth and loss of contact inhibition. Similarly, in the human glioblastoma cell line U373, US28 activated …
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Investigating and exploiting the latency-associated expression of the human cytomegalovirus gene US28 in early myeloid lineage cells.
… the HCMV-encoded chemokine receptor homologue US28, which is expressed during latent infection of CD14+ monocytes, is necessary for maintaining HCMV latency in these monocytes and, in the absence of US28 protein expression, HCMV undergoes lytic infection. US28 expression was found to attenuate …
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Phylogenetic Analysis of Human Cytomegalovirus pUS27 and pUS28: Ascertaining an Independent or Linked Evolutionary History
… receptor homologs, products of the US27, US28, UL33 and UL78 genes. G protein-coupled receptors (GPCR) are the largest family of cell surface proteins, found in organisms from yeast to humans. In this research, phylogenetic analysis was used to investigate the origins of the US27 and US28 …
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The roles of human cytomegalovirus US27 gene product during virus infection
… G protein-coupled receptors (GPCRs): US27, US28, UL33, and UL78. The US28 gene product is a functional chemokine receptor that exhibits a variety of signaling outcomes. In contrast, the US27 gene product is an orphan with no known chemokine ligands. We have found that US27 triggers several …
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Characterisation of T cell responses to proteins expressed during Human Cytomegalovirus latency
… to other key latency-associated viral proteins; US28, UL111A, and UL144. Using overlapping peptide pools designed to cover the whole of the predicted amino acid sequence of these HCMV proteins, in combination with fluorescent ELIspot (FluoroSpot), ELISA, and intracellular cytokine staining, I …
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Ligand induzierte Phosphorylierung des Chemokin Rezeptors CCR5: strukturelle Analyse und Funktion
… mit einer konstitutiv internalisierenden C5aR-US28-Chimäre eine Ligand unabhängige Cointernalisierung. Eine phosphorylierungsdefiziente C5aR-Mutante, die nicht in der Lage war, β-Arrestin zu binden, konnte CCR5 nicht cointernalisieren. Damit weisen die Ergebnisse auf einen …
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Analysis of two hypervariable human cytomegalovirus genes, UL146 and UL139
… other genes (UL55, UL74, UL75, UL115, US9 and US28), and is consistent with the theory that recombination has played a role in HCMV evolution. The absence of linkage between highly variable genes complicates attempts to examine associations between genotype and disease, as many combinations of …