Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"urothelial carcinoma"”.
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MOLECULAR PROFILING OF UROTHELIAL CARCINOMA
… of this thesis was to molecularly characterize urothelial carcinoma (UC) at the transcriptional level using gene expression microarrays to improve the classification and pathogenetic understanding of this disease. In the first two studies (Articles I and II), gene expression profiling was used …
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Inhibition of Urothelial Carcinoma By Type I Interferon Activation of The Innate and Adaptive Immune Response
… (IFN-I) has potent anti-tumor effects against urothelial carcinoma (UC) and may be an alternative treatment option for patients who do not respond to BCG standard of care. However, the mechanisms that mediate the IFN-I-stimulated immune responses against UC are not fully elucidated. Herein, we …
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The Role of microRNAs in Bladder Urothelium Development and Tumorigenesis
… group suggest that there may be more than one urothelial progenitor. Bladder cancer is the fifth most common cancer in the United States and the second most prevalent genitourinary malignancy. Urothelial carcinoma accounts for 90% of bladder cancers. Based on clinical and histological studies, …
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Investigating couplet strategies incorporating 4 pillars of cancer therapy
… the issue of disease stratification in dogs with urothelial carcinomas. In male dogs specifically, uroepithelial cancers include invasive urothelial carcinoma and prostate carcinoma. The inability to distinguish invasive urothelial carcinoma involving the prostate from prostate carcinoma results …
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PATHOLOGY OF THE UROGENITAL TRACT IN DOMESTIC ANIMALS
… is organized into two main topics: canine urothelial carcinoma and tumours of the genital system (ovarian and testicular tumours). My research into urothelial carcinoma began with an analysis of the grading systems proposed in veterinary medicine. The relationship between tumour morphology …
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Smac Mimetic and Combination Immunotherapy for the Treatment of Urothelial Cell Carcinoma
… Here, I adopted an orthotopic murine model of urothelial carcinoma (MB49) resistant to prominent immune-stimulating therapies BCG mycobacterium and PD-1/PD-L1 checkpoint blockade. I found treatment with a monovalent SM, LCL161, generated T lymphocyte-dependent cures of MB49, retaining potent …
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Lessons from a pilot study of screening for upper tract urothelial cell carcinoma in Lynch Syndrome
… to develop other cancers, including upper tract urothelial carcinoma (UTUC) that has an estimated lifetime risk of 0.2-25%, above that of the general population. Our aim was to assess the prevalence of UTUC in a Lynch syndrome cohort undergoing screening for CRC, to determine the need for a UTUC …
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Interpretable Tumor Localization in Bladder Cancer Histopathology Using Deep Multiple Instance Learning
… and eosin (H&E)-stained bladder cancer (urothelial carcinoma) slides. We found that CLAM was more robust against overfitting to spurious confounders when compared with a traditional approach, resulting in more interpretable outputs. Additionally, we generated high-resolution tumor …
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Design and Validation of Medical Devices for Photothermally Augmented Treatments
… and Laser Light to Treat Human Transitional Cell Carcinoma of the Urinary Bladder in a Rodent Model Using a rodent model we explored a treatment method for Transitional Cell Carcinoma (TCC) in the urinary bladder in which Single Walled Carbon Nanohorn (SWNH) solution and 1064 nm laser light are …
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Genetic analysis of Kmt2d loss in tumorigenesis using genetically engineered mouse models
… in human lymphoma, melanoma, and epithelial carcinoma. Biochemically, KMT2D shapes the cellular enhancer landscape as the major writer of the putative enhancer mark H3K4me1. Given the critical role of cellular enhancer landscape in determining cellular lineage in embryonic development, it is …
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Retrospective review of open versus laparoscopic radical cystectomy for the treatment of bladder cancer: complications and oncological outcome
… remains the standard of care for muscle-invasive urothelial carcinoma. Our centre (Groote Schuur Hospital) has been performing laparoscopic radical cystectomies since 2009. We aimed to audit our data regarding complications and oncological outcome and compare it to data obtained from patients …