Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"uropathogenic"”.
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The Nature of Uropathogenic Escherichia coli ST127
Uropathogenic Escherichia coli ST127 is a recently emerged clone that is reported to cause a small, but significant, proportion of urinary tract infections. Paradoxically, the low prevalence of ST127 in most published studies is also accompanied by a virulence potential significantly higher than …
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A Proteomics Approach to Investigate Uropathogenic Escherichia coli
Uropathogenic Escherichia coli (UPEC) is the most commonly known cause of urinary tract infection (UTI). The possession of many virulence factors and global dissemination of multi-drug resistant UPEC strains is posing a critical risk to treatment worldwide. The most virulent UPEC strains have …
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Isolation and Characterization of Bacteriophages Targeting Uropathogenic E. coli
… common human bacterial infections, caused by uropathogenic E. coli (UPEC). Conventionally, UTI’s are treated with antibiotics, such as sulpha-mathoxazole/trimethoprim and ampicillin. However, a significant proportion of UPEC strains have become resistant to these antibiotics, resulting in a …
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Characterization of β-lactamases and Porins in Uropathogenic E. coli
Uropathogenic Escherichia coli, the predominant causative agent of urinary tract infections, are becoming increasingly resistant to commonly utilized β-lactam antibiotics leading to higher medical costs, prolonged treatment from persistent infections, and increased mortality. This rising resistance …
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Intercellular communication in uropathogenic Escherichia coli and the probiotic Lactobacillus reuter
… (AI-2) in the regulation of virulence factors of uropathogenic Escherichia coli J96, determine if the probiotic Lactobacillus reuteri RC-14 produced AI-2, and evaluate if secreted products from the probiotic could affect pathogen recognition by the host. Disruption of luxS (AI-2 synthesis) in E. …
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An Investigation into the utilisation of ethanolamine by uropathogenic E. coli
… organism responsible for 75% of all cases. Uropathogenic E. coli (UPEC) naturally reside in the gastrointestinal tract (GI tract) and infect the urinary tract via migratory ascension of the urethra. Ethanolamine, an amino alcohol found naturally in phospholipids as phosphatidylethanolamine, …
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Pilus biogenesis in uropathogenic Escherichia coli : An electrophysiology study on the PapC usher
Uropathogenic Escherichia coli are the main causal agents of urinary tract infections. Pili are bacterial surface adhesive organelles that are critical virulence factors in the successful colonization of the urinary tract by uropathogenic E. coli. Pili are composite in structure and are formed from …
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Studies on the architecture and on transferability of pathogenicity islands of uropathogenic Escherichia coli strain 536
… and functional analysis of DNA regions of uropathogenic Escherichia coli strain 536 that belong to the flexible E. coli gene pool. The first part of this thesis focused on the identification and structural characterisation of pathogenicity island V of strain 536 (PAI V536). PAI V536 is …
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Studies on the Role of Histone-like Proteins in Gene Regulation in Uropathogenic Escherichia coli Isolate 536
… of histone-like proteins in gene regulation in uropathogenic Escherichia coli isolate 536 was monitored. The histone-like nucleoid structuring protein H-NS is a global regulator in Escherichia coli that has been intensively studied in non-pathogenic strains. No comprehensive study on the role of …
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Investigating the effect of prophylactic D-mannose treatment on adhesion of Uropathogenic Escherichia coli to the human bladder epithelium
… annually, mainly women, and primarily caused by Uropathogenic Escherichia coli (UPEC). Treatment of UTIs is challenged by the continued increase of antibiotic resistance, and alternative strategies are necessary to reduce this disease burden. The pathology of UTI rapidly develops when …
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Role of <i>bax</i>, <i>ibpA</i>, <i>ibpB</i> and <i>cspH</i> Genes in Protecting CFT073 (Uropathogenic <i>Escherichia coli</I>) Against Salt and Urea Stress
Uropathogenic <i>Escherichia coli</i> (UPEC) are the primary cause of 80 to 90% of uncomplicated urinary tract infections. After entering the urinary tract, uropathogenic <i>E.coli</i> has to tolerate high levels of salt and urea in urine to cause a successful infection. The osmotic stress imposed …
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Cranberry metabolites with urinary anti-adhesion activity
… blood cell (HRBC) anti-agglutination assay with uropathogenic P-fimbriated E. coli. Active urine fractions but not control urine or inactive fractions were found to contain complex mixtures of oligosaccharides but not PACs. An octasaccharide, consisting of a tetrameric, β-(1→4)-linked D-glucose …
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Synergistic Effects of Monoculture Biofilm Dispersion and Antibiotic Treatment
… increase antibiotic efficacy of CAUTI treatment, uropathogenic Pseudomonas aeruginosa PAO1 and Escherichia coli F11 biofilms were cultured on silicone disks, modeling the surface of urinary catheters. These biofilms were then treated with two potential dispersal agents and challenged with …
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Analysis of the genome organization and fitness traits of non-pathogenic Escherichia coli strain Nissle 1917 (O6:K5:H1)
… those of analogous islands in the genome of uropathogenic E. coli strain CFT073 (O6:K2(?):H1), but they lack important virulence genes of uropathogenic E. coli (hly, cnf, prf/pap). Evidence for instability of GEI IINissle 1917 was given, since a deletion event in which IS2 elements play a …
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Identification and characterisation of Group 3 Innate Lymphoid Cells in the renal tract
… The commonest cause of uncomplicated UTI is Uropathogenic Escherichia coli and we used this organism in murine models to interrogate the role of ILC3s within this setting. The project focussed on three vital components of effective defence: the epithelium, mononuclear phagocytes (MNPs) and …
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The Role of Host Hormones and Metabolites in the Regulation of Virulence in Enterohemorrhagic Escherichia coli (EHEC)
… is sensed by EHEC, Citrobacter rodentium and uropathogenic E.coli. In EHEC and C.rodentium we showed that serotonin inhibits the transcription of the LEE PI. We also determined that the mechanism of LEE PI inhibition by serotonin is through the reduction of autophosphorylation of the bacterial …
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Investigating Bacterial Filamentation as a Survival Strategy for Infection
… bacteria such as Escherichia coli. Filamentous uropathogenic E. coli appear to play important roles in combating host defences during urinary tract infections through their decreased engulfment by phagocytic immune cells like macrophages. Bacterial filamentation, as a strategy to avoid …
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The Physiological and Morphological Responses of the Bladder Urothelium to Differential Injury
… we used a UTI injury model from instillation of uropathogenic E. coli: UPEC), a cellular damage model from single dose protamine sulfate: SDPS) instillation, and an inflammatory damage model from multiple instillations of lipopolysaccharide: LPS). We identified that UPEC injury increased the pain …
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Conservation Of The Intracellular Bacterial Community Pathogenic Pathway In Urinary Tract Infection
… 13 million women annually in the United States. Uropathogenic Escherichia coli: UPEC) is the predominant etiologic agent of UTI; however, several other uropathogens, including Klebsiella pneumoniae, are also significant causative agents. In a murine cystitis model, UPEC utilize a multistep …
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