Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"urokinase plasminogen activator"”.
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Soluble urokinase plasminogen activator receptor in venous ulcers
… give rise to better treatments.<br/>Urokinsae plasminogen activator receptor (uPAR), a GPI anchored 3‐domain<br/>protein exists either attached to cell wall or in soluble forms (suPARI‐III, suPARI<br/>& suPARII‐III fragments). Cleavage of uPAR results in a number of nonproteolytic<br/>functions …
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Targeting the Urokinase Plasminogen Activator System Combined with Chemotherapy-a Potentially Novel Therapeutic Approach for Pancreatic Cancer
… explores the potential of targeting the urokinase plasminogen activator (uPA) system, a well-documented factor in cancer progression as a therapeutic strategy in PDAC management, particularly in conjunction with the chemotherapeutic agent, Gemcitabine. Using publicly available datasets, …
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Dissection of receptor functions through the generation of a tcu-PA cleavage resistant u-PAR: a u-PA independent active u-PAR
… inflammation, wound healing, and tumor invasion. Urokinase plasminogen activator receptor (u-PAR) has been widely studied in both systemic and cellular processes. Systemic roles for u-PAR include angiogenesis, inflammation and cancer while cellular roles include cell proliferation, survival, …
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Production of Extracellular Matrix-Degrading Proteases by a Rat B Cell Line.CRL-1631
… metalloproteinases (MMPs) and components of the urokinase plasminogen activator (uP A) system. Our studies include RT-PCR of CRL-1631 eDNA revealing mRNA for MMP-2, MMP-9, TIMP-1, TIMP-2 and uPAR. MMP-2 and MMP-9 activity was verified by gelatin zymography. TIMP-1, TIMP-2 and uPAR protein …
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Multiscale Mathematical Modelling of Cancer Invasion
… the matrix metalloproteases (MMP) and the urokinase plasminogen activator (uPA).<br/><br/>This thesis has investigated the complex process of cancer growth and spread that occur across several different spatial scales, in order to gain a better understanding of the key processes involved …
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Phase I Clinical Trial of Recombinant Oncolytic Newcastle Disease Virus for Intracranial Meningioma
… site to be replaced with that belonging to urokinase plasminogen activator (rLAS-uPA). This site is cleavable exclusively by the uPA receptor (uPAR), which is overexpressed in canine meningioma. The rLAS-uPA represents a targeted therapy that has the potential to be efficacious against …
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Differential mechanisms by which the aryl hydrocarbon receptor attenuates liver regeneration
… proteins, the c-Met transmembrane receptor and urokinase plasminogen activator (uPA). However, this growth response is limited by the expression of plasminogen activator inhibitor-1 (PAI-1) and TGF-?, which terminates hepatocyte proliferation. The goal of these studies was to determine the …
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Characterisation of cytokine secretion in malignant gliomas
… growth factor receptor 1 (sVEGFR-1) and urokinase plasminogen activator (uPA). The data also show that tumour tissue revealed increased expression of follistatin and G-CSF with little expression of prolactin. In conclusion, these results suggest that potential candidate biomarkers can be …
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Proteolytic mechanisms involved in the metastasis of human melanoma cells
… which could contribute to the process, plasminogen activation by tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) is one such mechanism. Extensive reports in the literature (reviewed in the introduction) indicate that most tumour cells synthesize uPA and that …
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Kininogen and Ferritin in Tumorigenesis
… cell surface have been identified including urokinase plasminogen activator receptor (uPAR, CD87), cytokeratin 1(CK1), globular “head” of C1q (gC1q-R) and tropomyosin, of which uPAR is the most studied and most relevant to tumorigenesis. Tumor cells frequently overexpress uPAR. The work …
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Y-box binding protein-1 (YB-1) is a bio-marker of aggressiveness in breast cancer and is a potential target for therapeutic intervention
… we find an association between YB-1 and urokinase Plasminogen Activator (uPA) expression in the basal-like subtype. We then show that YB-1 is involved in the regulation of uPA expression. More importantly, silencing YB-1 or uPA results in a significant reduction in cancer cell invasion. …
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Multiscale Modelling of Cancer Response to Viral Therapy
… micro scale, we focus on essential dynamics of urokinase plasminogen activator (uPA) system which is one of the important proteolytic systems responsible for the degradation of the ECM, with notable influence in cancer invasion. While sourced by the cancer cells that arrive during their …
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Role and regulation of prostaglandin production in granulosa cell DNA synthesis during ovarian follicular development.
… as well as its involvement in the regulation of urokinase plasminogen activator, an enzyme playing an important role in tissue remodelling. Granulosa cells from the first (F1), fifth, and sixth (F5-6) largest preovulatory follicles were cultured in the presence of TGF$\alpha ,$ and/or TGF$\beta …
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How the Outside Gets in: Linking Social and Physical Environments with Physiology and Body Size in Wild Baboons
… acute inflammation: c-reactive protein, soluble urokinase plasminogen activator receptor, interleukin 6, interleukin 1-beta, and tumor necrosis factor alpha. We test two measures of early-life adversity: maternal loss and a cumulative measure that incorporates 5 different potential sources of …
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Investigating spatial distribution and dynamics of membrane proteins in polymer-tethered lipid bilayer systems using single molecule-sensitive imaging techniques
… state and distribution of GPI-anchored urokinase plasminogen activator receptor (uPAR) and the transmembrane protein αvβ3 integrin. Experiments on uPAR showed that receptor oligomerization and raft sequestration are predominantly influenced by the binding of natural ligands, but are …
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Mathematical modelling of the innate and adaptive immune response to solid tumours
… describe the interactions between cancer cells, urokinase plasminogen activator (uPA), plasminogen activator inhibitor-1 (PAI-1), plasmin, extracellular matrix (ECM) and the immune response. The mathematical model focuses on the effect of the immune response on cancer invasion by assuming that …