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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"urea cycle"”.
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Urea Cycle Operation in the Diabetic Rat
Made available in DSpace on 2015-05-13T15:27:01Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 8009054.PDF: 7191925 bytes, checksum: 466f13c20f12839eead745ebafb7aa74 (MD5) Previous issue date: 1979
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Amino Acid Balance and Imbalance in the Pig With Emphasis on Urea-Cycle Metabolism and Interorgan Amino Acid Transfers
Several experiments were conducted to investigate amino acid metabolism in pigs as affected by arginine deficiency, fasting and amino acid imbalances. Supplemental citrulline replaced arginine for growth in pigs fed arginine-deficient diets whereas ornithine supplementation was without effect. …
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DNA analysis of Ornithine Transcarbamylase (OTC) deficiency in South African patients
… number are due to defects in enzymes of the urea cycle. This cycle has evolved to cope with waste nitrogen disposal and the de novo synthesis of arginine. There are five distinct enzymatic steps in the urea cycle, and defects in each, result in a biochemically distinct disease. Four of these …
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Thermodynamics of Ligand Binding to Glutamate Dehydrogenase
… causing increased ATP production via the Krebs Cycle and excess insulin release. In addition, GDH over activity leads to depletion of glutamate, which is the source of the urea cycle precursor N-acetylglutamate. Reduction of N-acetylglutamate leads to reduced urea cycle activity and increased …
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The Orotic Aciduria of Chemical Hepatotoxicity (Liver Disease, Alcohol, Galactosamine)
… or as a consequence of excessive demands on the urea cycle. Orotic acid is a precursor of nucleic acids which may depend on carbamyl phosphate, a product of the urea cycle, for synthesis under some physiological conditions. This thesis describes five previously unreported causes of orotic …
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Nitrogen Metabolites During Exercise in the Horse
… by exercise or treatment and suggests that the urea cycle was not impaired during exercise. These results did not show any metabolic evidence for a role of increased blood NH$\sb3$ in fatigue development at the level of the central nervous system.
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The Physiological and Biochemical Understanding of 5’-Amp Induced Deep Hypometabolism
… possibly due to its intricate role in the urea cycle. Supplemental arginine is clearly more beneficial both in suppressing arousal and increasing the survival rate after 12 hours in DH.</p>
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In silico systems analysis of biopathways
… are possible. Finally, a detailed model of urea cycle that includes gene regulatory networks, metabolic pathways and signal transduction is demonstrated by using our approaches. A system biological interpretation of the observed behavior of the urea cycle and its related transcriptomics …
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Understanding the gender-based mechanism of mso in als mice: a metabolic characterization of the sod1-g93a mouse model
… disrupts nitrogen metabolism, specifically the urea cycle. The results of these studies show that untreated presymptomatic SOD1 mice have altered nitrogen metabolism and show decreased levels of several urea cycle intermediates in the plasma compared to their wild-type counterparts. These plasma …
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Responses to abomasal infusion of casein, hydrolyzed casein or methionine-lysine and dietary protein degradability in lactating cows
… amino acids, branched-chain amino acids, and urea cycle amino acids were increased by the infusion of the caseins. There were differences between the caseins in their effects on individual plasma free amino acids. Methionine-lysine infusion increased plasma lysine and taurine, a metabolite of …
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Regulation and roles of nutrient-dependent mitochondrial fusion
… changes in levels of metabolites involved in the urea cycle, Krebs cycle and REDOX balance. Findings in this project suggest putative mechanisms linking amino acid metabolism, mitochondrial dynamics and mitochondrial function.
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Urea-N Recycling in Lactating Dairy Cows
… (RDP) and rumen undegradable protein (RUP) on urea-N recycling and microbial N flow. Eight mid-lactation Holstein cows were assigned to a repeated 4 x 4 Latin square. The diets were isoenergetic with RDP and RUP concentrations arranged in a factorial design (10.0 and 12.5% RDP and 5.6 and 8.1% …
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The Role of Gut Microbiota Urease in the Host With Liver Disease
… is nitrogen metabolism. In the colon, bacterial urease hydrolyzes host-derived urea into carbon dioxide and ammonia. Colonic ammonia can subsequently be absorbed by the host or utilized by the gut microbiota for additional nitrogen metabolism. In patients with liver disease such as cirrhosis and …
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Proteomic profiling of Nguni cattle liver tissue using gel and Gel-Free approaches: methodology development and potential applications
… In addition, proteins that play a role in the urea cycle (which is believed to contribute to the Nguni cattle’s enhanced metabolic ability) were all identified with both techniques. The RP-RP method was selected as the most appropriate method for future research linked to this work and will be …
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TUMOR PROMOTING FUNCTIONS FOR THE METABOLIC REGULATOR SIRT5
… enzyme involved in the rate-limiting step of the urea cycle. By deacylating CPS1, SIRT5 promotes urea cycle function and clearance of toxic ammonia. Sirt5-deficient mice fail to up-regulate CPS1 activity and show elevated blood ammonia during fasting. SIRT5 regulates mitochondrial respiration by …
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Community Composition and Function of the Hindgut Microbiome in Seaweed-Eating Marine Fish
… Clostridia co-expressed genes related to the urea cycle and polyamine biosynthesis, suggesting a role in nitrogen provisioning to the community. Results suggest that the coexistence of Bacteroidia and Clostridia relies on metabolite exchange, particularly cobalamin precursors produced by …
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Effects of carnitine on medium-chain fatty acid metabolism in newborn pigs
… of inhibiting oxidative processes as well as the urea cycle.
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The use of cultured cells with defects of citrulline metabolism in diagnosis and in the study of intercellular communication
… from defects in two consecutive enzymes of the urea cycle, argininosuccinate synthetase and argininosuccinate lyase. Fibroblast cell lines were derived from patients with these disorders and the diagnoses, which had been made on the basis of amino acid levels in plasma and urine, were confirmed …
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