Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"urate"”.
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Genetics of serum urate regulation in human health and disease
… of blood pressure. Excessively high serum urate levels (hyperuricaemia) are associated with a wide range of diseases. With the exception of gout, where monosodium urate crystals are known to trigger a painful inflammatory response, both the causality and the underlying mechanisms linking …
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An investigation into the physiology of urate pellet excretion by Parcoblatta fulvescens (Saussure and Zehntner) (Dictyoptera: Blattellidae)
Physiological parameters involved in formed urate pellet excretion by the wood cockroach, <i>Parcoblatta fulvescens</i> were investigated. Uric acid excretion by last instar juvenile <i>P. fulvescens</i> was studied first. Food consumption, urate and non-urate pellet excretion patterns show a …
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Μελέτη της σωληναριακής μεταφοράς του ουρικού οξέος στην πολυκυστική νόσο των ενηλίκων με τη χρήση των δοκιμασιών πυραζιναμίδης και προβενεκίδης
… the urine, because of extensive reabsorption of urate. Many factors affect the tubular transport of urate, some by increasing the tubular transport (extracellular volume increment, sodium load, hyperglycemia, ADH, contrast media, drugs e.t.c.), and others by decreasing it (organic acids, …
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Modeling Uric Acid Kidney Stones Disease in D. melanogaster using RNAi and Dietary Modulation
… </em>uric acid can be further metabolized by urate oxidase into readily excreted allantoin. We hypothesize that if urate oxidase enzyme activity and dietary purine are both critical in uric acid kidney stone formation, then urate oxidase knockdown in combination with dietary purine …
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Uric acid metabolism in the Dalmatian coach hound
… of these abnormalities is a high incidence of urate urolithiasis in this breed. Other diseases such as recurrent dermatitis, chronic cystitis and deafness are also found in the Dalmatian and whether there is any causal relationship with the uric acid disorder is unknown. In terms of the …
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Elevated levels of low molecular weight substances in the red cells of some mammalian species imply unsuspected antioxidant strategies
… of substances including tyrosine, tryptophan, urate, and urate riboside occuring within the red cells of some species. Whereas novel evolutionary adaptations may characterise most of these species-specific variations, the ability of red cells to produce urate is proposed to be an inducible …
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MarR Family Transcriptional Regulators from Streptomyces coelicolor
… DNA can be efficiently attenuated by the ligand urate, which also quenches the intrinsic fluorescence of PecS, indicating a direct interaction between urate and PecS. In vivo measurement of gene expression showed that activity of pecS and pecM genes is significantly elevated after exposure of S. …
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Biochemical Studies Of Human Hyperuricaemia
… in all systems. There is no evidence for urate binding to plasma proteins in either healthy or hyperuricaemic individuals from occlusion, ultrafiltration, electrophoresis or gel filtration experiments. Urate appears to be present in human leucocytes combined to protein or other component …
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The effect of allopurinol on left ventricular mass in haemodialysis patients
… analysis of patients who achieved a reduction in urate of 20% or more with allopurinol, allopurinol significantly reduced LVMI- change in LVMI placebo +3.6 ± 10.4 versus -2.9 ± 7 p= 0.03. Allopurinol had no demonstrable effect on BP, FMD, Aix or PWV. <br/><br/>This thesis shows that, compared with …
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Obesity-Related Metabolic Syndrome: Investigations into Novel Clinical Markers and Possible Causes
… rate (ESR); haemoglobin A1c (HbA1c); urate; ferritin; liver function tests (LFT): alkaline phosphatase (AlkPhos); alanine transferase (ALT); aspartate transferase (AST); gamma glutamyl transferase (γGT); bilirubin (2) Protective Markers; (a) serum fat cell-derived, adiponectin (Adpn) …
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The Effects of Epidural Deracoxib on the Ground Reaction Forces in an Acute Stifle Synovitis Model
… mediate clinical signs and effects of a sodium urate crystal-induced stifle synovitis in dogs, and to compare the effects of epidural versus subcutaneously injected deracoxib. Study Design: Experimental, randomized, double-blinded, placebo controlled modified cross over design. Animals or Study …
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The Effect of Allopurinol on Left Ventricular Mass in Patients with Treated Essential Hypertension
… velocity, blood pressure control, biomarkers (Urate, High sensitivity C-Reactive Protein (HsCRP), Thiobarbituric acid reactive substances (TBARs), N-terminal prohormone B-Type Natriuretic Peptide (NTproBNP), Procollagen type I carboxy-terminal Propeptide (PICP) and soluble ST2 (sST2) and other …
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Dietary and Serum Biomarkers, and Glycaemic status: Relationships with Type 2 Diabetes Mellitus and Incident Dementia
… positive associations with dementia risk, while urate showed a negative association. CoxBoost model identified fructosamine, MIC-1, urate, plasminogen activator inhibitor-1, and vitamin E as key dementia predictors. T2D moderated associations between dietary factors and dementia, though no …
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PRG4/CD44/PP2A Signaling Axis: A Significant Regulator of Gout Arthritis
… a common chronic arthritis caused by monosodium urate (MSU) crystal deposition in joints leading to activation of synovial resident macrophages and downstream production of interleukin-1b (IL-1b). Xanthine oxidase (XO) catalyzes purines into uric acid (UA) and reactive oxygen species (ROS) that …
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The Analgesic Effects of Epidural Ketamine in Dogs With a Chemically Induced Synovitis: A Comparison Between Pre - or Post - Injury Administration
… before or after the induction of a sodium urate crystal synovitis provides analgesia in dogs. In Part I, sixteen dogs were anesthetized with propofol (4 mg kg-1 intravenously). A sodium urate crystal synovitis was induced in the right stifle and allowed to develop for 12 hours. These dogs …
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Inter-individual variation in saliva antioxidant status in relation to periodontal disease
… as a biomarker of oxidative tissue damage. Urate, ascorbate and albumin contributed 85% of the total scavenging antioxidant capacity (TAA) which followed a diurnal rhythm (peak 5.OOpm, nadir 3.OOam). Salivary antioxidant flow rate was significantly lower in individuals with severe PD (TAA …
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Kinetic and metabolic studies in HPRT deficiency
… for a month. He was shown to have haematuria and urate crystalluria, and had a serum urate of 0.8mmol/l (reference range 0.12-0.5mmol/l). The diagnosis was confirmed by demonstrating a haemolysate hypoxanthine-guanine phosphoribosyltransferase activity of 550μU/mg Hb (reference range …
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Glucose-6-Phosphatase in Metabolic Disease and Cancer
… pathway, which produce precursors to lactate and urate, respectively. Transcriptomic analysis revealed that these metabolic changes were accompanied by increased transcription of genes in both pathways. In addition to stimulating these metabolic pathways, we observed that G6PC deletion stimulates …
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Role of Bcl-2 proteins in neutrophil activation and delayed apoptosis in crystal-induced arthritis
… by the deposition of crystals of monosodium urate monohydrate (MSUM) and calcium pyrophosphate dihydrate (CPPD) in the synovial fluid of joints, results from the interaction of the crystals with neutrophils. Neutrophils (whose function in the body is to remove hazardous microorganisms and …
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Advancing precision medicine: harnessing data from diverse sources and individuals to predict medication efficacy and safety.
… of evaluating the impact of vitamin C on serum urate levels in Hmong adults, both with and without gout/hyperuricemia (Gout/HU). Enrolling a total of N=135 Hmong adults, including those with or without Gout/HU, participants provided comprehensive medical, demographic, dietary, and anthropometric …
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