Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"uptake mechanisms"”.
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Synthesis of 2,4,6-Substituted Pyrrolo[2,3-d]pyrimidines as Potential Anticancer Agents
… development, such as folate function, its three uptake mechanisms inside human cells, antifolates’ role in chemotherapy, <em>et. al</em>. In addition, the Structure-Activity-Relationship design rationale for the series of antifolates will also be discussed. Nevertheless, the details of …
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STRUCTURAL INVESTIGATION OF EXTRACELLULAR VESICLES AND THEIR INTERACTION WITH BIOMIMETIC INTERFACES
… under study. Then, an investigation of the EVs uptake mechanisms was carried with bottom-up approaches. In this contest, there is an urging need to design different membrane models with different complexities and geometries, to be used as biomimetic interfaces for mimicking the interaction …
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Occurrence and fate of endocrine disrupting chemicals and other hydrophobic organic compounds in a tropical river in Kenya
… the well-established SR, despite differences in uptake mechanisms with both sampler materials. This study demonstrated that passive samplers are versatile tools that can be applied in remote locations, and with proper storage, they can be transported and analyzed far afield.
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Acclimation of marine macrophytes (Saccharina latissima and Zostera marina) to water flow
… low water flow occurred via upregulation of DIC uptake mechanisms in both S. latissima and Z. marina. Both species increased their ability to generate CO2 in the boundary layer by increasing external carbonic anhydrase and in Z. marina by also increasing proton extrusion and photosynthetic …
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Uptake and distribution of 3H-cholesteryl oleyl ether in tissues of cholesterol-fed New Zealand White and Watanabe Heritable Hyperlipidemic rabbits
… to identify organs and cells active in the uptake of plasma cholesteryl ester (CE) at critical stages in the progression of atherosclerosis. The iliac arteries were injured by balloon catheterization to compare the repair process between the two animals. The morphology of the atherosclerotic …
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Pre-clinical development of cyclodextrin-based nanoparticles for oral delivery of protein/peptide drugs-in vitro and in vivo evaluation
… vivo were carried out to evaluate the intestinal uptake mechanisms of the formulations. In vitro studies using the Caco-2 cell monolayer model and ex vivo (rat intestinal tissue) studies showed that insulin glulisine NPs enhanced the epithelial permeability of insulin. Lastly, the formulations …
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Flux of cadmium through a laboratory food chain (media-algae-mussel) and its effects
… deductions, more information about chemical mechanisms and background ecophysiological data is needed, otherwise accumulation reports may become misleading. It was found that the best growth and accumulation results were achieved by harvesting algae from a zinc deficient media containing 7 …
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Describing the Cell Biology of Saprolegnia parasitica: Role of Metals and Respiration
… on Saprolegnia parasitica growth, metal uptake, and respiratory function. We cultured S. parasitica in chemically defined media supplemented with or depleted of essential metals using specific chelators— Bathocuproinedisulfonic acid (BCS) (a high-affinity Cu(I) chelator), Ferrozine …
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Anatomical, developmental and physiological aspects of silica in wheat
… soluble/deposited silica partitioning and uptake of silica by wheat. The morphology of a particular phytolith (the papilla) from inflorescence bracts of 70 species from Triticum (wheat). Hordeum, Aegilops families and Secale cereale was analyzed. Using papilla pit number and/or diameter it …
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Single quantum dot tracking for quantitative molecular imaging
… living cells to assess delivery efficiency and uptake mechanisms. In this method, single quantum dot mobility information is used in conjunction with single-molecule brightness measurements to develop novel single-cell metrics of delivery efficiency. These metrics are used to investigate the …
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Cationic Glycopolymers for DNA Delivery: Cellular Internalization Mechanisms and Biological Characterization
Understanding the biological mechanisms of polymeric DNA delivery is essential to develop vehicles that perform optimally. In this work, the cellular internalization mechanisms of poly(glycoamidoamine) (PGAA) DNA delivery polymers were investigated. Polymer:DNA complexes interact with cell-surface …
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THORIUM SPECIATION IN SYNTHETIC ANHYDRITE, PLACER ILMENITE CONCENTRATE, AND TITANIA SLAG: IMPLICATIONS FOR THORIUM GEOCHEMICAL BEHAVIOR, SEQUESTRATION, AND BENEFICIATION
… and their metallurgical products, and the uptake mechanisms of thorium into these materials. Gaining an understanding of thorium in these materials will improve both thorium extraction and sequestration methods. Conditions present in the Sulfuric Acid Roasting Method for rare-earth element …
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GABA as a Putative Neurotransmitter in the Optic Lobes of the Crab HEMIGRAPSUS NUDUS
… Biochemical analysis of <sup>3</sup>H-GABA uptake revealed little surface receptor binding as picrotoxin and bicuculline did not appear to effect uptake. Similar biochemical experiments showed little glial . involvement. 2,4-diaminobutyrate ( L-DABA ), shown in other studies to …
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Cellular uptake and biological activity of synthetic hammerhead ribozymes
… and a fundamental understanding of cellular uptake mechanisms. Chimeric 2'-O-methylated hammerhead ribozymes proved to be significantly more stable (>4000-fold) in serum than unmodified RNA ribozymes and exhibited high in vitro catalytic activity. The cellular association of an internally …
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Modulating macrophage phenotype for obesity therapy
… of these phenotypes. Next, I investigate uptake mechanisms of dextran in inflammatory macrophages in vitro and adipose tissue depots in vivo. I determine that dextran nanocarriers of higher molecular weights (≥ 70 kDa) are well posed for specific targeting to obese adipose tissue. …
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Investigation of the interactions between Trypanosoma congolense invariant surface glycoproteins and components of the mammalian immune system
… ISG75 has been implicated in trypanocidal drug uptake mechanisms. The function of other ISGs including all ISGs in *T. congolense* is unknown. The aim of the work here was to identify ligands for ISGs in *T. congolense*. First, the *T. congolense* ISG gene repertoire was investigated as a whole. …
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Gold Nanoparticles as a Delivery System of Oligonucleotides into the Brain
… and can enter cells by both active and passive uptake mechanisms and can cross the blood-brain barrier in vivo and in vitro. The aim of this study was to investigate the potential of 5nm gold glyconanoparticles as a delivery system for oligonucleotides into the brain. Three ligand formulations …
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Molecular mechanism of Trypanosoma brucei Aquaglyceroporin 2
… Aquaglyceroporin 2 (TbAQP2) is required for the uptake of two of the drugs used clinically, pentamidine and melarsoprol. TbAQP2 mutations or the formation of a chimeric gene with TbAQP3 (TbAQP2X3) cause pentamidine-melarsoprol cross-resistance (PMXR). TbAQP2 is an aquaporin, a type of water …
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Development and evaluation of amphotericin B Loaded iron oxide nanoparticles for targeted drug delivery to systemic fungal infections
… with dialysis method were evaluated. Second, uptake (with fluorescence microscopy and flow cytometry) and killing efficacy (with susceptibility testing) of AMB-IONP in fungal clinical isolates of Candida species were evaluated and compared with standard drug AMB deoxycholate (AMB-D) data. …
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