Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1007 for “"upregulation"”.
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PATHOGENIC ROLE OF PHOSPHODIESTERASE TYPE 5 UPREGULATION IN CARDIAC ISCHEMIA/REPERFUSION INJURY
… oxygen species (ROS) during I/R leads to upregulation of PDE5, which contributes to pathological changes following acute myocardial infarction (AMI). Adult male ICR mice were subjected to 30 minutes of in vivo or ex vivo I/R. To examine the role of ROS, a subset of hearts were perfused …
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Functional Significance of the Upregulation of Adhesion Molecules on Irradiated Endothelial Cells
… for cancer. Damage to the endothelium and upregulation of inflammatory responses are major side effects of radiotherapy, but the mechanisms behind these processes are not clear. A key component of the inflammatory response is leukocytes adhesion to the endothelium in a multi-step process …
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Mechanism of tissue transglutaminase upregulation and its role in ovarian cancer metastasis
… inhibitor, SD-208, blocked TGF-β1 induced TG2 upregulation and EMT in vitro and tumor dissemination in vivo, which confirms the link between TGF-β1 and TG2 in EMT and tumor metastasis. TG2 expression was correlated with the number and size of self-renewing spheroids, the percentage of …
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Molecular Basis of Upregulation of IL-17 in Estrogen Model of Inflammation
Interleukin-17 (IL-17) plays a major role in inflammation by regulating the induction of various proinflammatory genes, which aid in the recruitment and activation of neutrophils. Although IL-17 is considered to be protective in infection, overproduction of IL-17 in conditions like autoimmune …
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Upregulation of Cystathionine-β-synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
… carcinogenesis. Here, we report CBS expression upregulation begins in premalignant colonic specimens. Additionally, forced upregulation of CBS in an adenoma-like colonic epithelial cell line (NCM356) is sufficient to induce increased NCM356 cell bioenergetics, proliferation, invasion through …
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Upregulation of PIP3-dependent RAC Exchanger 1 (P-Rex1) Promotes Prostate Cancer Metastasis
Activation of Rac by guanine-nucleotide exchange factors (GEFs) at the leading edge of the cell plays an important role in directional cell migration, a critical step of tumor metastasis cascades. We investigated the role of P-Rex1, a novel specific GEF for Rac, in human prostate cancer metastasis. …
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Upregulation of heme oxygenase-1 and activation of Nrf2 by the phytochemicals in protandim
… the use of Protandim as a potential method for upregulation of antioxidant defenses and protection of heart cells against an oxidative challenge. Future studies will focus on optimizing phytochemical induction of Nrf2-mediated antioxidant defenses in relevant in vivo models of CVD.
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Pathological Upregulation of a Calcium-Stimulated Phosphatase, Calcineurin, in Two Models of Neuronal Injury
Excitotoxic calcium influx and activation of calcium-regulated systems is a common event in several types of neuronal injury. This mechanism has been the focus of intense research, with the hope that a more complete understanding of how neuronal injury affects calcium-regulated systems will provide …
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Upregulation of COX-2 protein expression in porcine macula densa with L-NAME treatment
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] COX-2 inhibitors are newly developed drugs which are widely used for controlling pain and inflammation. Blocking this enzyme impedes the production of the prostaglandins that cause pain and swelling. However certain …
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Investigating the functional significance of the upregulation of Cyclin D2 and p21 following Apc loss in vivo
… is activated following loss of Apc in vivo. This upregulation is noteworthy as c-Myc is implicated in stem cell survival, proliferation, apoptosis and tumourigenesis. Previous studies have shown c-Myc dependency for both apoptosis and proliferation following activation of the Wnt pathway, however …
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Atr-Mediated Cd47 and Pd-L1 Upregulation Restricts Radiotherapy-Induced Immune Priming and Abscopal Responses In Colorectal Cancer
… activation. This post-irradiation CD47 and PD-L1 upregulation can be observed across various human solid tumor cells. Concordantly, rectal cancer patients with poor responses to neoadjuvant radiotherapy exhibited significantly elevated post-irradiation CD47 levels. The combination of radiotherapy, …
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Sulforaphane sensitizes TRAIL-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated upregulation of DR5
… overexpression of catalase inhibited SFN-induced upregulation of DR5 and almost completely blocked the cotreatment-induced apoptosis. Furthermore, the SFN-mediated sensitization to TRAIL was efficiently reduced by administration of a blocking antibody or small interfering RNAs for DR5. These …
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Inflammasome upregulation and activation in photoreceptors of type 2 diabetes and N-methyl-N-nitrosourea models is attenuated by Wedelolactone
Inflammation is known to play an important role in the pathogenesis of diabetic retinopathy (DR) and some aspects of retinal neurodegeneration although the precise underlying mechanisms linking these pathologies are not fully understood. Inflammation and oxidative damage are linked pathogenic …
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Butyrate-induced upregulation of intestinal glucose transport and signaling pathways represent a possible nutrient therapy for individuals with malabsorptive disorders
… model for the human intestine to test for the upregulation of GLUT2 mRNA abundance by butyrate and other SCFA. Next, the impact of butyrate on glucose transport by the intestine was examined using the Sprague Dawley rat as an in vivo model. Finally, proglucagon mRNA, and the G-protein coupled …
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Upregulation of Reactive Oxygen Species During The Retrovirus Life Cycle and Their Roles In A Mutant of Moloney Murine Leukemia Virus, Ts1-Mediated Neurodegeneration
… we observed reactive oxygen species (ROS) upregulations: one at low levels during the early infection phase and another at high levels during the late infection phase. Initially we hypothesized that p53 might play an important role in <em>ts</em>1-mediated astrocytic cell death. …
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Importance of MAPK and PKC in cerebrovascular endothelin receptor changes
… ischemic stroke. Previous studies have shown an upregulation of contractile ETB receptors in the ipsilateral middle cerebral artery (MCA) after experimental focal ischemia and a similar upregulation is also seen after organ culture of MCA. Furthermore, studies have shown an involvement of protein …
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Regulation and Targeting of Fyn in Human Cutaneous Squamous Cell Carcinoma
… HaCaT human keratinocyte cell line resulted in upregulation of FYN mRNA (200-fold) and protein, but did not increase the expression of other SFKs. We identified two nucleotides 74 bases upstream of the human FYN gene transcription start site as necessary for FYN upregulation in HaCaT-Ras cells. …
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A Novel Mechanism of Skin Tumor Promotion Involving Interferon-Gamma (Ifnγ)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling In Epidermis
… in epidermis. CHRY treatment also led to upregulation of unphosphorylated Stat1 (uStat1) at later time points. In addition, CHRY treatment also led to upregulation of IRF-1 mRNA and protein which was dependent on Stat1. Further analyses demonstrated that topical treatment with CHRY but not …
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