Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"upa"”.
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The uPA receptor in ovarian cancer. Regulation by EGF and the estrogen responsive membrane receptor GPR30. Soluble uPAR in diagnosis and prognosis.
… is part of the malignant phenotype, and the uPA receptor (uPAR) plays a central role in cell migration. We studied the role of EGF and estrogen on cell migration and uPAR expression in ovarian cancer cell lines. We also analyzed the diagnostic and prognostic value of cleaved forms of the uPAR …
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Biochemical And Genetic Studies of Quebec Platelet Disorder
… enzyme urokinase plasminogen activator (uPA) in platelets. Individuals with QPD experience delayed-onset bleeding after hemostatic challenges that is attenuated with fibrinolytic inhibitor therapy. The aims of this thesis were to: 1) determine if increased platelet uPA contributes to QPD …
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Role of Plasminogen and Urokinase-Type Plasminogen Activator in Cardiac Mesenchymal Cell Migration In Vitro
… show that urokinase-type plasminogen activator (uPA) conversion of plasminogen into plasmin is an important mediator of cell migration. In the developing chick heart, uPA has been implicated as a mediator of atrioventricular (AV) cushion cell migration, however the role of the plasminogen/plasmin …
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Phase I Clinical Trial of Recombinant Oncolytic Newcastle Disease Virus for Intracranial Meningioma
… to urokinase plasminogen activator (rLAS-uPA). This site is cleavable exclusively by the uPA receptor (uPAR), which is overexpressed in canine meningioma. The rLAS-uPA represents a targeted therapy that has the potential to be efficacious against meningioma when administered systemically. …
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Targeting the Urokinase Plasminogen Activator System Combined with Chemotherapy-a Potentially Novel Therapeutic Approach for Pancreatic Cancer
… targeting the urokinase plasminogen activator (uPA) system, a well-documented factor in cancer progression as a therapeutic strategy in PDAC management, particularly in conjunction with the chemotherapeutic agent, Gemcitabine. Using publicly available datasets, we first demonstrated that …
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Proteolytic mechanisms involved in the metastasis of human melanoma cells
… (tPA) and urokinase plasminogen activator (uPA) is one such mechanism. Extensive reports in the literature (reviewed in the introduction) indicate that most tumour cells synthesize uPA and that it is this enzyme, particularly when receptor-bound, which plays a role in invasion. UCT-Mel 3 is …
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Studying Microglia-Mediated Neurodegeneration Using Cocultures
… assays identified potential roles for urokinase (uPA) and spleen tyrosine kinase (SYK) in microglia-mediated neurodegeneration. uPA is an extracellular protease that may also regulate migration, inflammation and proliferation in association with its receptor uPAR. SYK signals downstream of other …
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AGRICULTURE URBAINE ET PÉRIURBAINE POUR LA SÉCURITÉ ALIMENTAIRE EN AFRIQUE DE L'OUEST. LE CAS DES MICRO-JARDINS DANS LA MUNICIPALITÉ DE DAKAR
… the context of Urban and Peri-urban Agriculture (UPA) micro-gardens, a simplified version of hydroponics, represent an interesting opportunity for producers, because they are characterized by a high efficiency in the use of water (2-3 l/m2/per day) and by a great spatial versatility. Moreover the …
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Y-box binding protein-1 (YB-1) is a bio-marker of aggressiveness in breast cancer and is a potential target for therapeutic intervention
… YB-1 and urokinase Plasminogen Activator (uPA) expression in the basal-like subtype. We then show that YB-1 is involved in the regulation of uPA expression. More importantly, silencing YB-1 or uPA results in a significant reduction in cancer cell invasion. As there are no commercially …
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Computational Methods to Identify and Target Druggable Binding Sites at Protein-Protein Interactions in the Human Proteome
… structure-based virtual screening. The tight uPAR•uPA interaction offers a platform to test methods that leverage hot spots on both the protein receptor and ligand. A method is described that enriches for small molecules that both engage hot spots on the protein receptor uPAR and mimic hot …
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Groundwater Modeling and Hydrogeological Parameter Estimation: Potomac Aquifer System, SWIFT Research Center
… identical except for the Upper Potomac Aquifer (UPA) layer 1, as the model has a large change in aquifer thickness with distance from TW-1 that the Theis-based calculations do not consider. Travel times from the monitoring wells to TW-1 were calculated with the single and multi-layered models …
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Private Provision of Public Goods: Uniform Price Mechanisms with a Threshold and Dynamics with a Tipping Point
… goods: The uniform price auction mechanism (UPA) collects an endogenously determined uniform price from everyone offering at least that price, while the uniform price cap mechanism (UPC) collects the uniform price from everyone offering at least that price, plus the full offer of everyone …
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Multiscale Mathematical Modelling of Cancer Invasion
… (MMP) and the urokinase plasminogen activator (uPA).<br/><br/>This thesis has investigated the complex process of cancer growth and spread that occur across several different spatial scales, in order to gain a better understanding of the key processes involved during invasion. At first, we …
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Functional in vitro analyses of lipid raft-associated cathepsin b: implication for the invasive phenotype of inflammatory breast cancer
… the tumor </p> <p>cell surface. We observed that uPA, uPAR and enzymatically active </p> <p>cathepsin B were all present in caveolae fractions isolated from </p> <p>SUM149 cells. Using a live-cell proteolysis assay, we demonstrated </p> <p>that both IBC cell lines degrade type IV collagen. The …
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Differential mechanisms by which the aryl hydrocarbon receptor attenuates liver regeneration
… receptor and urokinase plasminogen activator (uPA). However, this growth response is limited by the expression of plasminogen activator inhibitor-1 (PAI-1) and TGF-?, which terminates hepatocyte proliferation. The goal of these studies was to determine the influence of AhR on these moieties in …
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Preparation and Evaluation of Molecular Imaging Probes Targeting the Urokinase Plasminogen Activator System
… probe for the urokinase plasminogen activator (uPA) system, which has been shown to play a critical role in cancer metastasis, tumour aggressiveness and likelihood of progression. Two classes of small molecule inhibitors carrying isotopes of iodine were synthesized and evaluated using in vitro …
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Design and Synthesis of Small-Molecule Protein-Protein Interaction Antagonists
… two, small-molecule antagonists targeting uPA-uPAR protein-protein interaction are presented. A total of 500 commercially-available compounds were previously identified by virtual screening and tested by a FP assay. Three classes of compounds were found with biological activity. The first …
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PGE2 Receptor Subsets Mediate HCG Regulation of the Plasminogen Activator/Plasmin System in Primate Periovulatory Follicles
… (tPA) and urokinase type plasminogen activator (uPA) and their inhibitor PAI-1 was measured in granulosa cells. uPA and PAI-1 mRNAs peaked 12 hours and 36 hours after hCG administration respectively. tPA mRNA decreased 36 hours after hCG. Celecoxib administration had no effect on any of these …
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