Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 290 for “"unnatural"”.
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Unnatural Ecopoetics: Unlikely Spaces in Contemporary Poetry
… toward and identification of what I am calling unnatural ecopoetics represents an important development for ecopoetics and more broadly for ecocriticism--first, through broader applicability of ecopoetic theory and second, through increased clarity surrounding the term ecopoetics. The …
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Unnatural glycopeptides with application on cancer research
… and patients with cancer when using these new unnatural glycopeptides. On the other hand, antifreeze glycoproteins have recently attracted interest due to their use as crystal inhibitors for applications such as tumor cryotherapy. However, the mechanism of action of these glycoproteins is …
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Grieving unnatural death : a pastoral care challenge
Dissertation (MA (Practical Theology))--University of Pretoria, 2023.
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Metabolic Pathways for Natural and Unnatural Sialic Acids
… mechanisms for hIBM pathogenesis. The use of unnatural sialic acids, such as SiaDAz, and metabolic carbohydrate engineering is enabling deeper understanding of the biological roles of sialic acid. In Chapter 3, I determined that different cell lines have impairments at different metabolic …
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Design and Synthesis of Natural and Unnatural Macrocycles
<p>Macrocycles have received growing appreciation for their potential in probing a broader biological space, and there are a significant number of bioactive macrocycles in nature. In addition, a macrocyclic scaffold provides interesting features, including high binding affinity and target …
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Synthesis of unnatural analogues of pancratistatin and narciclasine
… synthesis of several different types of unnatural analogues of Amaryllidaceae constituents. Development and refinement of existing and design and execution of new approaches towards the synthesis of C-1 analogues of pancratistatin and A-ring heterocyclic analogues of narciclasine are …
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Structure-based design of unnatural glycopeptides for cancer diagnosis and therapy
En esta tesis se han desarrollado glicopéptidos no naturales de MUC1 utilizando un diseño racional basado en estructura. Este trabajo se ha apoyado en datos previamente reportados con el fin de mejorar la afinidad de estos derivados in vitro con anticuerpos bien estudiados, incorporando sustitutos …
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Using Unnatural Amino Acids and Nonnative Cofactors for Metalloprotein Design and Engineering
Different positions for anchoring the salen cofactor to the Mb scaffold were observed to affect both the rate and selectivity of the artificial enzyme in a modular and accumulative fashion. Molecular dynamic simulations indicate that these changes may be due to the steric effects of the linker arms …
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Site-specific labeling of cellular proteins with unnatural substrates of biotin ligases
E. coli biotin ligase (BirA) catalyzes the site-specific ligation of biotin to the lysine within its 15-amino acid peptide substrate (AP). We harnessed the high peptide substrate specificity of BirA to develop a general methodology for site-specific protein labeling with biophysical probes. We …
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Development Of Unnatural Amino Acid Based Spectroscopic Probes For Chemical And Biological Applications
… similar to the existing scaffold, such as unnatural amino acids (UAAs). Therefore, in this thesis we describe the utility of several UAAs as site-specific spectroscopic probes as well as their applications in the study of various chemical and biophysical problems. Specifically, we …
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Electrochemical Detection of Anti-Biofilm Activity Using Unnatural Amino Acid-Containing Antimicrobial Peptides
… of antimicrobial peptides (AMP) containing unnatural Tic-Oic amino acids have been developed for this purpose. Traditional methods such as biological assays are the standard by which antibiotics are judged, but they have their drawbacks, such as the lengthy test times and the costs …
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Synthesis of unnatural analogues of narciclasine: Chemoenzymatic synthesis of 2-epi-1-hydroxymethylnarciclasine
An approach to the synthesis of novel C-1 analogues of narciclasine has been developed. The synthesis relies on chemoenzymatic dihydroxylation of an arene, Stille coupling, and an intramolecular Heck reaction to affect key transformations. The synthesis of the targeted C-1 analogues addresses a gap …
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Understanding the Speciation of Ruthenium Arene Complexes as Precursors to Unnatural Enzyme Cofactors
Ruthenium arene complexes have been extensively explored as metallo-pharmaceuticals and as small molecule catalysts. Exploring the overlap between these areas, this thesis describes a body of work aimed at quantitatively understanding the biological speciation and catalytic behaviour of ruthenium …
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A Forensic Study of Unnatural Deaths in Kuwait: Epidemiological, Virtual Autopsy and DNA Investigations
… The results showed that most people who died of unnatural deaths were more predominant in the age group 20-29 years (third decade). Road Traffic Accidents accounted for 65% of accidental deaths, and 4% out of them were related to alcohol consumption. The results also illustrated that the highest …
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Metalloprotein engineering with unnatural amino acids: application in functional heme-copper oxidase and azurin
… could coordinate to metal. Incorporation of unnatural amino acids greatly expands the toolbox of bioinorganic chemists. Several methods for unnatural amino acid incorporation have been developed, including cavity complementation, total synthesis, native chemical ligation, expressed protein …
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Towards The Development Of Intrinsically Fluorescent Unnatural Amino Acids For In Vivo Incorporation Into Proteins
Acridonylalanine (Acd) is a fluorescent unnatural amino acid that can site specifically label a protein of interest during protein translation. Acd’s incorporation relies on an evolved tRNA synthetase that specifically charges Acd to its cognate tRNA. As the protein mRNA sequence is being …
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Synthesis of compounds of natural and unnatural origin by intramolecular alkylations / by Neil John Shirley
Bibliography: leaves 213-223
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Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials
… several branched peptide libraries containing unnatural amino acids to target the high-affinity binding site of RRE RNA (RRE IIB), with the idea that branching in peptides can provide multivalent contacts with folded RNA structures and boost binding affinity and selectivity for the target. …
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Thermodynamic and Spectroscopic Investigations of Novel Antimicrobial Peptides containing Unnatural Amino Acids with Model Membrane Systems
… of antimicrobial peptides that incorporate unnatural amino acids to impart specific physicochemical properties onto these peptides. Circular Dichroism (CD), isothermal titration calorimetry (ITC) and calcein leakage assays were conducted and it was determined that there are two distinctly …
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