Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"unfolded protein response (UPR)"”.
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Unfolded Protein Response (UPR) Signaling in Hepatic Stellate Cells (HSC) as a Key Regulator of Liver Fibrosis
… (HSCs), which secrete extracellular matrix (ECM) proteins such as collagen to form fibrotic scars. Activated HSCs produce vast amounts of fibrotic proteins that require folding and processing prior to secretion. Increased protein folding demands cause endoplasmic reticulum (ER) stress and initiate …
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N-Glycosylation Protects Host from Mycobacterial Infection
… molecule to nascent secretory or membrane proteins within the endoplasmic reticulum (ER) for protein folding and trafficking. Defects of N-glycosylation induce the unfolded protein response (UPR), which sensitizes infected macrophages to intrinsic apoptosis. This apoptosis differs from the …
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Role of Abberant Proteolysis in the Pathogenesis of APL
… leukemia (AML), is caused by PML-RARN1, a fusion protein resulting from chromosomal translocation involving the promyelocytic leukemia (PML) and the retinoic acid receptor N1 (RARN1) genes. PML-RARN1 promotes misfolding of nuclear hormone receptor corepressor (N-CoR) and that accumulation of …
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Modulation of the Magnetic Properties of Aqueous Metal Ions and the Bioelectrodynamic Effects on Cancerous and Noncancerous Cells
… the cancerous cells headed to apoptosis by the unfolded protein response (UPR), TNF/TRAIL, and p53 oncogene activation. Alternatively, the noncancerous cells show a significant increase in cell migration/wound healing after exposure to the treated media with no activation of apoptosis …
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Quercetin and chloroquine synergistically induces cell death in glioma cells via the increase of Ca2+ and ROS levels
… quercetin and CQ accumulated poly-ubiquitinated proteins and activated unfolded protein response (UPR) in these cells. We found that combined treatment with quercetin and CQ increases intracellular and mitochondrial Ca2+ levels. The cell death by quercetin plus CQ was effectively inhibited by …
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Targeting mdr1 and endocrine therapy-resistant cancers through estrogen receptor
… reticulum (EnR) stress signaling cascade, the unfolded protein response (UPR), has documented in various human cancers and diseases. However, the precise roles of UPR signaling in development of hormone-dependent gynecological cancers were unknown. Here we show that the activation of UPR prior …
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Modeling The Unfolded Protein Response And Its Connection To Cellular Stress
… plays a pivotal role in cellular functioning. Proteins undergo modifications in the ER. The cell monitors protein folding and has a quality control. The incorrectly folded proteins are tagged for degradation or sent back to the refolding cycle. Upon accumulation of incorrectly folded proteins …
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The unfolded protein response and HLA-B27 misfolding: implications for ankylosing spondylitis
The unfolded protein response (UPR) detects the presence of misfolded proteins in the endoplasmic reticulum (ER) and subsequently relieves ER stress by increasing the folding capacity of the ER. The secretory pathway substrate HLA-B27 is highly associated with the chronic inflammatory disease …
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Regulation of B lymphocyte terminal differentiation and death by the transcription factor Blimp-1
B lymphocyte induced maturation protein-1 (Blimp-1) und X-box-binding protein-1” (XBP-1) sind als Transkriptionsfaktoren unverzichtbar für die terminale Differenzierung von B-Lymphozyten zu Immunglobulin (Ig)-sezernierenden Plasmazellen. Ebenso stellen die unfolded protein response (UPR) und das …
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Necrotic cell death: A novel outcome of BHPI-hyperactivation of the anticipatory unfolded protein response
… ERa to hyperactivate a lethal anticipatory unfolded protein response (UPR), hijacking a normally protective and pro-proliferative action of estrogen and ERa. We have found that BHPI effectively inhibits proliferation of and kills breast cancer cells expressing constitutive and antiestrogen …
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The degradation of membrane proteins from the mammalian endoplasmic reticulum
Membrane glycoproteins of the secretory pathway that cannot adopt their native conformation are targeted for dislocation from the endoplasmic reticulum (ER) membrane for subsequent degradation by the cytosolic proteasome. This thesis investigates factors influencing the catalyzed destruction of MHC …
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Characterization of the degradation of wild-type and mutant HFE proteins during stress signalling in the endoplasmic reticulum
HFE is a transmembrane protein that becomes N-glycosylated during transport to the cell membrane. It acts to regulate cellular iron uptake by interacting with the Type 1 transferrin receptor and interfering with its ability to bind iron-loaded transferrin. There is also evidence that HFE regulates …
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Improving cancer therapy strategies via cellular stress and immune modulation
… cell death through hyperactivation of the unfolded protein response (UPR). Preclinical studies in osteosarcoma (OS), chondrosarcoma (CS), and Ewing sarcoma (ES) demonstrated potent ErSO mediated cytotoxicity and anti-metastatic activity, significantly extending survival even in late stage, …
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Mechanisms of Impaired Efferocytosis of Synovial Macrophages in Knee Osteoarthritis
… found that signs of cell stress, such as the unfolded protein response (UPR), were significantly enriched. Selective inhibitors were used to block the UPR pathway and there was a rescue effect. Overall, this study identified mechanisms contributing to impaired efferocytosis in OA and helped to …
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Dilations of the Endoplasmic Reticulum Contribute to Spongiform Degeneration and Unlock a Door to a Unified Model of Neuropathological Features in Prion Diseases
… degeneration, neuronal loss, and misfolded prion protein (PrPSc) deposition. The mechanistic origins of spongiform degeneration, which manifests as intracellular vacuolation in neurons, have remained unclear. We considered similarities between the spongiform degeneration in prion diseases and …
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Characterization of the antiviral activity of cyclosporine A against dengue virus
… CsA against DENV-2 is independent of its target proteins, cyclophilin A or B, which are not required host factors for DENV-2 in Huh7 and A549 cells. In Huh7 and A549 cells, CsA induces interferon regulatory factor-1 (IRF1)-dependent antiviral gene expression. While CsA does not increase IRF1 …
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Using cannabidiol and trazodone to treat protein misfolding neurodegenerative disease in C. elegans
… by the accumulation of the misfolded proteins Amyloid-Beta (Aβ1-42) and/or hyperphosphorylation of Tau (p-Tau). Despite the lack of a cure for the disease, it is well known that targeting signaling pathways involved in reactive oxygen species (ROS) or the unfolded protein response …
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Synergistic inhibition of prostate tumor progression with a combination of curcumin and ursolic acid in the diet
… of PCa compared to single agents. Analyses of protein isolated from the ventral prostate of these mice indicated that the combination reduced activation of oncogenic signaling pathways, including STAT3, AKT, and mTORC1 compared to controls. The combination also modulated critical cell …
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Regulation of mammalian IRE1α: Co-chaperones and their importance
When unfolded proteins accumulate in the endoplasmic reticulum (ER), the unfolded protein response (UPR) increases ER protein folding capacity to restore protein folding homeostasis. Unfolded proteins activate UPR signalling across the ER membrane to the nucleus by promoting oligomerisation of …
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HIV Protease Inhibitors Trigger Lipid Metabolism Dysregulation Through Endoplasmic Reticulum Stress and Autophagy
… depletion of ER calcium stores, activating the unfolded protein response (UPR). UPR activation further lead to an alteration of cellular differentiation through downstream transcription factor CHOP. At the same time, HIV PIs also altered adipogenesis via differential regulation of the adipogenic …
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