Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"undruggable target"”.
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Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach
… which induces the transcription of Notch target genes. Abnormal expression or mutations in the different components of the pathway are associated with a number of diseases and cancers. An enhanced activity of Notch signalling resulting from a mutation in the extracellular domain is …
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Towards Inhibition of Oncogenic RhoA Signaling using Stapled Peptides
… less toxic treatments are needed. A challenge in targeted therapy is the "undruggability" or difficulty in developing traditional small molecule inhibitors to many of the identified oncogenic targets, including the Ras superfamily of small GTPases. Peptide therapeutics are emerging as promising …