Global ETD Search
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Showing 1 to 3 of 3 for “"undecaprenyl diphosphate synthase (UPPS)"”.
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Multi-target drug discovery against Staphylococcus aureus and Trypanosoma brucei infections
… active compounds are potent inhibitors against undecaprenyl diphosphate synthase (UPPS), an essential enzyme involved in cell wall biosynthesis pathway. Besides, they bound to an AT-rich DNA dodecamer (CGCGAATTCGCG)2 and were found to increase the melting transition by up to 24 °C using …
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Targeting isoprenoid biosynthesis for drug discovery
… targets: a trans-prenyl transferase farnesyl diphosphate synthase (FPPS), and a cis-prenyl transferase undecaprenyl diphosphate synthase (UPPS). In chapter 2, I report the discovery and x-ray crystallographic structures of 10 structurally diverse compounds (benzoic/diketo/phosphonic acids, …
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ANTIMICROBIAL CHARACTERIZATION AND THERAPEUTIC APPLICATIONS OF NOVEL SYNTHETIC THIAZOLE COMPOUNDS AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCI AND ENTEROCOCCI
… possible targets: YubA, YubB and YubD. YubB is undecaprenyl diphosphate phosphatase (UPPP) and UPPP as well as undecaprenyl diphosphate synthase (UPPS) were inhibited by 1, as confirmed by traditional enzyme inhibition assays. YubA and YubD are annotated as transporters and may also be targets …