Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"uncoupling protein 2"”.
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Mitochondrial Involvement in Pancreatic Beta Cell Glucolipotoxicity
… mitochondrial ROS and associated cell loss, uncoupling protein-2 (UCP2) protein levels and activity were probed in NEFA exposed INS-1E cells. It is concluded that UCP2 neither mediates palmitate-induced mitochondrial ROS production and the related cell loss, nor protects against these …
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Uncoupling Lipid Metabolism from Inflammation in Adipose Tissue
… Interestingly, deficiency of fatty acid binding protein 4 (FABP4, also know as aP2) in macrophages suppresses inflammatory activation of the cells and contributes to whole body insulin sensitivity in an animal model. However, the mechanism of how FABP4 deficiency leads to the suppressed …
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The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia
… observed an LCAR mediated increase in levels of uncoupling protein 2 (UCP-2). In a series of experiments we observed a correlation between UCP-2 expression, the reversible modulation of mitochondrial membrane potential, and a decrease in cell death after OGD. These observations taken together …
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The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia
… observed an LCAR mediated increase in levels of uncoupling protein 2 (UCP-2). In a series of experiments we observed a correlation between UCP-2 expression, the reversible modulation of mitochondrial membrane potential, and a decrease in cell death after OGD. These observations taken together …
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The Role of UCP2 in Pancreatic Cancer Metabolism and Its Potential as a Radiosensitizer
<p>Uncoupling protein 2 (UCP2) is a mitochondrial protein that regulates the flow of protons down the gradient established by the electron transport chain (ETC) without generating ATP, thus uncoupling the proton gradient from ATP generation. In tumors, specifically pancreatic cancer (PDAC), the ETC …
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Metabolic Mechanisms of Nutritionally Regulated Hormone Signaling on T Helper Cell Function
… mROS caused by IGF-1 treatment is mediated by uncoupling protein 2 (UCP2) activity, and that the effects of IGF-1 treatment can be reversed by UCP2 inhibition. Altogether, these studies implicate nutritionally regulated hormones in promoting CD4+ T cell metabolism and function both in health …