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Showing 1 to 2 of 2 for “"uncompetitive inhibition"”.

  1. Adenosine triphosphate is an allosteric inhibitor of coxsackievirus B3 3Dpol

    … regulation of 3Dpol by a small molecule. Inhibition assays investigating the relative affinities of a stalled coxsackievirus elongation complex for non-cognate nucleotides uncovered a mixed inhibition profile of ATP. Among the six picornavirus species tested, this mode of inhibition seems …

    colostate Repository record for Adenosine triphosphate is an allosteric inhibitor of coxsackievirus B3 3Dpol (opens in a new tab)

  2. Assessing the acetylcholinesterase inhibitory potential of novel pharmacophores for potential treatment of Alzheimer’s disease

    … regarded as possessing AChEI activity (≥ 60% inhibition at 5 µM). For the secondary screen, two subsets of structurally similar compounds, subset B (n = 508) and subset C (n = 545) were selected and evaluated. The AChEI activity for a further six compounds (C33, C43, C53, C82, C129 and C189) …

    pretoria Repository record for Assessing the acetylcholinesterase inhibitory potential of novel pharmacophores for potential treatment of Alzheimer’s disease (opens in a new tab)