Global ETD Search
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Showing 1 to 2 of 2 for “"unanchored ubiquitin"”.
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Proviral Roles of Ebola virus VP35 Ubiquitination
… unknown. Previously, we observed the host E3 ubiquitin ligase TRIM6 conjugates ubiquitin onto VP35 at lysine (K) 309. This post-translational modification was found to be proviral, but we did not know which VP35 role(s) ubiquitination regulated. We generated recombinant EBOVs encoding glycine …
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Regulation of DHX16-mediated Innate Immunity by Unanchored Polyubiquitin
… by post-translational modifications (PTMs), like unanchored (or free) polyubiquitin (poly-Ub), which properly regulate IFN-I to elicit responses as needed. Despite its known roles regulating critical IFN-I pathways, the extent to which unanchored poly-Ub is involved in innate immunity is unknown. …