Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"ultrasound contrast agents"”.
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Acoustic characterisation of ultrasound contrast agents at high frequency
… aims to investigate the acoustic properties of ultrasound contrast agents (UCAs) at high ultrasound frequencies. In recent years, there has been increasing development in the use of high frequency ultrasound in the fields of preclinical, intravascular, ophthalmology and superficial tissue …
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The Role of Ultrasound Contrast Agents in Producing Sonoporation
This dissertation successfully elucidated the physical mechanism of sonoporation. Oscillation of UCAs near a cell produced microstreaming that resulted in shear stress on the cell membranes. This shear stress resulted in sonoporation, a permeability change that allowed for the uptake of …
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Quantification of Ultrasound Contrast Agents Using High-Frequency Ultrasound
Ultrasound contrast agents (UCAs) are small microbubbles filled with gas. Because of their scattering properties, UCAs enhance the diagnostic capabilities of ultrasonic imaging. UCAs are associated with therapeutic or enhancing therapeutic applications of ultrasound and with possible adverse …
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Estimating the concentration of ultrasound contrast agents using ultrasonic backscatter in vitro
Ultrasound contrast agents (UCAs) are tiny microbubbles used clinically to enhance the contrast of B-mode images. Recently, UCAs have been combined with therapeutic ultrasound techniques to increase their effectiveness. These therapeutic techniques often require high concentrations of UCAs at …
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Production methods of radiation sensitive ultrasound contrast agents and their response to neutron irradiation
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms
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Effects of nutrition and ultrasound imaging on the cardiovascular system
… on two major areas: the biological effects of ultrasound and ultrasound contrast agents, and nutritional interventions to inhibit the development of atherosclerosis. Ultrasound is a highly flexible and affordable imaging modality that has proven clinically useful in many diagnostic situations …
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Examining the biophysics of ultrasound and contrast agent induced angiogenesis
… treatments. Current research suggests that ultrasound-ultrasound contrast agent treatment can be therapeutically beneficial, providing a noninvasive way to spatially and temporally target ischemic tissues. This type of angiogenic therapy can be used as an alternative to high risk …
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The Use of Ultrasound-Targeted Microbubble Destruction in Mediated Delivery of a Gadolinium Magnetic Resonance Imaging Contrast Agent Into Fibroblast Cells In Vitro
A method for delivering Gd-based MRI contrast agents by ultrasound-targeted microbubble destruction into fibroblast cells in vitro is presented. First, MRI contrast agents Gd-F-DOTP-ME and Gd-DOTA-4iBA are shown to associate with liposome microbubbles used as ultrasound contrast agents. Repeated …
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Non-linear, non-spherical bubble dynamics near a two fluid interface
… of the bubble column. The acoustic driving of ultrasound contrast agents near tissue layers has also been investigated, demonstrating a new mechanism for tissue damage due to the toroidal re-expansion, the membrane peeling phenomenon.
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Nanoparticle-coated polymeric microbubbles for revascularization
… polymer. Microbubbles are commonly used as ultrasound contrast agents, and the limited life time of microbubbles is the major challenge for microbubble applications. The coating of the nanoparticles enhanced the microbubbles’ stability, and at the same time, the microbubbles helped to reduce …
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Biomedical ultrasonics, cavitation, and sonoporation
… cavitation and sonoporation. Focussed ultrasound surgery can heat tissue to a temperature that causes protein denaturation and coagulative necrosis. For high-resolution focused ultrasound microsurgery, high working frequencies are necessary. We manufactured a highfrequency, …
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Spatial control of cavitation in therapeutic ultrasound
… using Optison[TM], a commercially available contrast agent. The performance of the rest of acoustic field in suppressing cavitation when cavitation is induced at the focus is investigated theoretically and checked experimentally. This first part shows that dual-frequency phased arrays could …
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Engineering Microbubbles with the Buried-Ligand Architecture for Targeted Ultrasound Molecular Imaging
… of this property, microbubbles are used as ultrasound contrast agents for signal enhancement. In addition, they are being developed for targeted diagnostic molecular imaging applications. Previous studies have shown that targeted microbubbles could induce complement activation and reduce …
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Improving the Specificity of Medical Ultrasound Imaging Using Scattering Spectrum Matching
Medical ultrasound imaging systems continue to evolve at a fast pace enabled by advances in transducer technology, analog mixed-signal electronics, and high-performance computing. Ultrasound imaging is used in numerous applications, including echocardiography and peripheral vascular imaging in …
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Collapse dynamics of ultrasound contrast agent microbubbles
Ultrasound contrast agents (UCAs) are micron-sized gas bubbles encapsulated with thin shells on the order of nanometers thick. The damping effects of these viscoelastic coatings are widely known to significantly alter the bubble dynamics for linear and low-amplitude behavior; however, their effects …
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Investigations of the Role of Triglycerides in Synthetic Colloidal Systems
… microbubbles, which are clinically employed as ultrasound-contrast agents. Theoretically, TGs may be able to flexibly coat the expanded microbubble interface during rarefaction. Preliminary acoustic experimentation indicates that microbubbles produced with triglycerides have longer lifetimes …
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Design and evaluation of drug loaded microbubbles for ultrasound guided cancer therapy
… and clinical use of several new anticancer agents. We succeeded in preparing microbubbles which are able to carry genetic (pDNA, siRNA) and chemotherapeutic (doxorubicin) drugs. We proved that these microbubbles can selectively deliver their genetic or chemotherapeutic drugs to melanoma …