Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"ultrasensitive"”.
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Ultrasensitive Biodetection based on Plasmonically-active Materials
… investigated. Overall, we have realized ultrasensitive and stable biodetection platform based on plasmonically-active materials, which can be potentially deployed in point-of-care and resource-limited settings
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Ultrasensitive DNA aptasensors based on exponential amplification reaction
… are amplified by the EXPAR technique for ultrasensitive detection. It is shown that the detection limit of a cocaine aptasensor is improved from 5 micromolar in assays without amplification to 0.8-1micromolar when EXPAR is applied, providing a 5-fold enhancement. The flexibility in …
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Nanoscale BioFETs for ultrasensitive pH and biomolecular detection
In the last decade, nanoscale field-effect transistor biosensors have proven to be powerful, ultra-sensitive, label-free electrical detectors of relevant molecules ranging from solution pH to proteins to nucleic acids. Such sensors are highly amenable to scale-up and mass production and are easily …
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Microfluidic Engineering for Ultrasensitive Molecular Analysis of cells
… the development of microfluidic technology for ultrasensitive and fast molecular analysis of cells. Chromatin immunoprecipitation (ChIP) assay followed by next generation sequencing serves as the primary technique to characterize the genomic locations associated with histone modifications. …
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Nanostructured Materials for Ultrasensitive Detection of Contaminants in Water
L'abstract è presente nell'allegato / the abstract is in the attachment
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Fluorescence correlation spectroscopy: ultrasensitive detection in clear and turbid media
… and the food industry, and to the fast and ultrasensitive detection of protein aggregates for the diagnosis of Alzheimer’s and other neurodegenerative diseases in clinical medicine. A prototype instrument has been built and allowed the detection and quantification of particles down to a few …
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Nanostructured Devices for Ultrasensitive and High Throughput Vibrational Spectroscopic Imaging
… of sets of probes and filters to enable rapid, ultrasensitive acquisition of unlimited number of molecular targets.
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Ultrasensitive Force Sensing with Nanospheres in an Optical Standing Wave Trap
This thesis details the experimental progress developing a state-of-the-art neutral force sensor using an optically levitated nano-sphere. Trapping 300 nm diameter fused silica spheres using a dual beam optical standing wave trap, we have experimentally reported a force sensitivity of 1.63 …
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Development of ultrasensitive electrochemical sensors based on nanocomposites for environmental applications
Water quality assessment is an essential component of environmental monitoring, which affects not only aquatic life but the surrounding ecosystem as well. The presence of organic and inorganic micropollutants such as carbamate pesticides and heavy metals in water is a crucial water problem …
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Ultrasensitive CMOS-compatible lab-on-a-chip integrated photonic sensors with wideband operation
Sensors are becoming increasingly important to human beings and have penetrated every part of life. The rapid development of the field of integrated photonics enables the opportunity of realizing integrated and compact sensing systems with fast analysis, low cost, and potential for mass production. …
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Ultrasensitive methods for the detection of biomolecular systems at the micro/nano scale
… DNA sequences of different olive cultivar. The ultrasensitive detection of DNA was also investigated by coupling microfluidic devices with the SPRi apparatus. A similar approach allowed a real time label-free detection of specific genomic DNA sequences carrying the â°39 thalassemia mutation. …
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Ultrasensitive quantification of circulating disease biomarkers through enzymatic labeling and single molecule counting
… research is on the development of simplified and ultrasensitive methods for quantifying low abundance biomarkers with the ultimate goal of developing robust tools for advancing disease diagnosis. In recent years there has been an immense expansion in the identification of sensitive and specific …
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The aluminum single-electron transistor for ultrasensitive electrometry of semiconductor quantum-confined systems
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1998.
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Development of luminescent probes for ultrasensitive detection of biopolymers, their complexes, and living cells
New luminescent probes with enhanced brightness convenient for bioconjugation were synthesized and tested in major biological applications including the detection of nucleic acids and living cells. The first project used luminescent lanthanide ion probes that take advantage of hyper-sensitive …
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Nanolaminated Plasmonics: from Passive to Active Nanophotonics Devices
… arrays to control the surface wettability for ultrasensitive SERS measurements. The hierarchical micro/nano plasmonic surface has densely packed intrinsic SERS-active hot spots that give rise to SERS EFs exceeding 107. This platform can take full advantage of low surface energy to control and …
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Ultratrace Neurotransmitters SERS Sensing
… is a powerful analytical technique for ultrasensitive detection of chemicals and biomolecules. As the high sensitivity of SERS requires analytes to be in close contact with a plasmonic substrate, the detection of analyte molecules with low chemical affinity towards the substrate is thus …
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Development of Gold Nanocluster-Based Biosensors
… and practical importance in the development of ultrasensitive biosensors based on surface-enhanced Raman spectroscopy (SERS). Manipulation of gold nanoclusters in a predictable and reproducible manner for the application of refined biochemical analysis still remains challenging. In this study, …
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Simulation and modelling to develop a nanopore-based device for ricin detection
… represents an exciting opportunity to develop ultrasensitive diagnostic devices that are both portable and affordable. Aptamer-encoded nanopores detect target molecules by binding to them to facilitate a corresponding blockage of ionic flow through the pore. Molecular dynamics simulations are …
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Synthesis and characterization of nanoparticle suspensions: Towards quantitative surface-enhanced Raman spectroscopic sensing
Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive technique with applications ranging from in vitro and in vivo biological sensing to chemical and explosives detection. In this thesis, we explore the design and characterization of suspensions of nanoparticles prior to their use for …
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