Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"ubr5"”.
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Studies on the autophagy gene WIPI4 and its interactor UBR5
Autophagy is a tightly regulated process that sequesters and delivers proteins and other cellular substances for degradation in the lysosome. Dysfunction of autophagy has been implicated in many diseases including neurodegenerative diseases, cancer, and infectious diseases. Beta-propeller …
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Investigation of the E3 ubiquitin ligase UBR5; a novel regulator of Hh gene expression
… project was to investigate the hypothesis that UBR5, the murine homologue of Hyd, acts as a novel regulator of Hh gene expression in mammals. To investigate this hypothesis in vivo, I utilized the developing mouse limb as a model system that is highly sensitive to abnormal Hh expression. …
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Studies on Cellular Nutrient Responses and Protein Degradation
… degradation pathways and an E3 ubiquitin ligase UBR5 in regulating the stability of the protein kinase WNK1, a key regulator of cellular ion homeostasis. Mutations that increase WNK1 protein expression cause familial hypertension, highlighting the importance of understanding the regulation of …
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IDENTIFYING THE ROLE OF TIP60 IN HEPATOCELLULAR CARCINOMA
… that HBx utilizes an E3 ubiquitin ligase, EDD1/UBR5 to destabilize TIP60. In inflammation induced liver cancer, I found that TIP60 plays a role in modulating innate immune response by its ability to regulate various interferon factors as well as different cytokines and chemokines. Using an in …
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Genetic interactors of the SWI/SNF chromatin remodelling complex in Caenorhabditis elegans
… in either of the E3 ubiquitin ligases ubr-5 (UBR5 in humans) or hecd-1 (HECTD1 in humans) can restore development to adulthood in swsn-1 loss-of-function mutants that otherwise die as embryos. Furthermore, I showed that SWI/SNF protein levels are reduced in swsn-1; snfc-5 double mutants and …
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Mechanisms of molecular switching in the Wnt signal transduction pathway
… data showing that apposition of Gro/TLE and UBR5, a HECT E3 ubiquitin ligase, by β-catenin promotes Gro/TLE ubiquitylation, earmarking it for extraction by the VCP/p97 ATPase and ultimately leading to inactivation of its repressive function. In Chapter 3, I present the results of a different, …
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Construction and Biological Characterisation of Custom Engineered Protein Degradation Tools.
… the E3 ligase Keap1; however another E3 ligase UBR5 was not observed to bind. Cell-based experiments were performed, and microscopy and luminescence assays were designed to test for AurA degradation by the polyproxins. Low expression of the polyproxins in mammalian cells and their weak binding …