Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"ubiquitin-proteasome system (UPS)"”.
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Hypertrophic Cardiomyopathy: A Review of Clinical and Molecular Characteristics and Effects and A Clinical Case Study
… of such mutant forms on the quality control ubiquitin-proteasome system (UPS) contribute to cardiac dysfunction. The E334K mutant cMyBP-C has been shown to destabilize its protein and lead to the impairment of the UPS, resulting in the clinical arrhythmias and cardiac dysfunction observed in …
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Age related memory loss and the role of the ubiquitin proteasome system
… as the accumulation of damaged proteins. The ubiquitin-proteasome system (UPS), responsible for breaking down damaged proteins, exhibits dysfunction in neurodegenerative disorders like Alzheimer's disease or dementia. While we acknowledge that proteasome function declines with age, its …
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Characterization of the IBR5-PAD1 Interaction in Arabidopsis Auxin Response
Many plant hormones utilize the ubiquitin-proteasome system (UPS) to modulate the expression of specific genes involved in various developmental processes as well as responses to environmental stress. In this process the target proteins are polyubiquitinated by a multi-subunit E3 ubiquitin ligase …
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Effects of mitochondrial dysfunction on neurofilament turnover and distribution in human neuroblastoma cells
… a number of proteins including α-synuclein, ubiquitin and neurofilaments (NFs). NFs, the intermediate filaments expressed in neuronal cells are responsible for the maintenance of axonal structure. Although NFs were the first proteins identified in LBs their role in PD pathogenesis has not …
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Regulation of Protein Degradation In The Heart By Amp-Activated Protein Kinase
<p>The degradation of proteins by the ubiquitin proteasome system is essential for cellular homeostasis in the heart. An important regulator of metabolic homeostasis is AMP-activated protein kinase (AMPK). During nutrient deprivation, AMPK is activated and intracellular proteolysis is enhanced …
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Regulation of Protein Degradation In The Heart By Amp-Activated Protein Kinase
<p>The degradation of proteins by the ubiquitin proteasome system is essential for cellular homeostasis in the heart. An important regulator of metabolic homeostasis is AMP-activated protein kinase (AMPK). During nutrient deprivation, AMPK is activated and intracellular proteolysis is enhanced …
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Differential regulation of the phosphorylated and dephosphorylated forms of the ubiquitin-conjugating enzyme Ubc6e
The ubiquitin proteasome system (UPS) is a key stress response employed by cells to remove damaged and misfolded proteins that accumulate in the endoplasmic reticulum (ER) during energy deprivation, hypoxia, or viral infection. Ubc6e is an ER-localised ubiquitin-conjugating enzyme that plays an …
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Harnessing the Anaphase-Promoting Complex for Targeted Protein Degradation
… of TPD involves co-opting components of the ubiquitin-proteasome system (UPS) to label disease-associated proteins with ubiquitin, thereby tagging them for destruction by the cellular protein degradation machinery. However, a major limitation in the field of TPD is that most UPS-based TPD …
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Regulation of Protein Degradation by ADP-Ribosylation
… is essential for cellular homeostasis. The Ubiquitin-Proteasome System (UPS) is responsible for the regulated breakdown of intracellular proteins. All proteins are not degraded at the same rate in the cell. For instance, global protein turnover rates in mammals change with an average time …
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Investigating the regulation of plant immunity by the N-degron pathway
… by unprecedented rates of climate change. The Ubiquitin Proteasome System (UPS) contributes to the regulation of plant immunity and a greater understanding of its role in these processes could lead to the future development of disease-resistant crops. The N-degron pathway is a subset of the UPS …
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Fragment-based approaches to probe the surface of the VHL E3 ligase
… in the control of protein homeostasis, E3 ubiquitin ligases are emerging as interesting targets for the development of chemical probes and drugs. Small-molecule modulation of E3 ligases can provide several advantages over other members of the ubiquitin-proteasome system (UPS), as E3 ligases …
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바이러스 감염시 미토콘드리아 E3 ubiquitin ligase 인 MARCH5의 새로운 생체 기능
… central role in preserving cellular homeostasis. Ubiquitin proteasome system (UPS) on the mitochondria is one of quality control systems that works as a first line barrier against aggregated or misfolded proteins. In this study, I investigated functional role of mitochondrial E3 ligase, MARCH5, …
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Targeting PfUCHL3 Using Chemically Constrained Peptides
PfUCHL3 is a highly conserved, dual specificity deubiquitinating and deNeddylating enzyme acting within the ubiquitin proteasome system (UPS) of *Plasmodium falciparum*, the deadliest and most prominent *Plasmodium* species responsible for the transmission of malaria to humans. Malaria kills on …
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The Systems Biology of the Protein Quality Control
The 26S proteasome, an ATP-dependent protease, is the main powerhouse for protein degradation in all eukaryotic cells. Proteostasis is maintained by the ubiquitin-proteasome system (UPS) targeting aberrant proteins whose accumulation and aggregation are hallmarks of aging and neurodegenerative …
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Effect of cellular factors on the generation of beta-amyloid.
… 'blob-like aggregates', are high copy number, ubiquitinated structures that originate from the nuclear/ER interface, and are not dependent on microtubules for their formation nor are they contained by the intermediate filament vimentin, indicating that they are neither aggresomes nor inclusion …
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Design and synthesis of molecular tools for the ubiquitin proteasome system
… 0.5% of the population living with dementia. The ubiquitin proteasome system (UPS), in particular the interaction between a mutant form of ubiquitin, Ubb+1, and the E2-conjugating enzyme E2-25K, has been identified as playing a possible pathophysiological role in the early and late stage …
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Fbxw7 Triggers Degradation Of Kmt2d To Favor Growth Of Mature B-Type Malignant Cells
The ubiquitin-proteasome system (UPS) precisely controls the levels of most proteins in a cell. As such, the UPS regulates cellular processes such as proliferation and survival and is dysregulated in a variety of diseases including cancer. Lymphoid malignancies are the fourth most common cancer and …
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Biophysical methods to study the ubiquitination of amyloidogenic proteins and proteasomal responses to protein aggregates
… of misfolded proteins are degraded by the ubiquitin-proteasome system (UPS), in which selective substrates are unfolded and cleaved into small peptides when passing through proteasome. The underlying pathogenesis of neurodegenerative diseases is at least partially contributed by the …
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Selective Degradation of Aggregated Tau Protein Via Vectored Nanobody-TRIM21 RING Fusion Constructs
… degraded by the intracellular Fc receptor and E3 ubiquitin ligase TRIM21. It was therefore hypothesised that intracellular aggregated tau could be targeted for degradation by exploiting this TRIM21 pathway. This thesis describes the development of TRIMinators, vectored constructs designed from the …
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Identification and characterisation of new factors and mechanisms regulating human cytochrome c oxidase biogenesis
… being its turnover controlled by the cytoplasmic ubiquitin-proteasome system (UPS), while increased oxidative stress had stabilising effects on the mature intramitochondrial form, which was shown to protect COX subunits from oxidatively-induced degradation.
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