Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"ubiquitin-mediated proteolysis"”.
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Investigating how ubiquitin-mediated proteolysis of AURKA contributes to its activity in the cell cycle
… AURKA protein is targeted for proteasome-mediated degradation by the FZR1 activated form of APC/C at the end of mitosis. This study focuses on characterisation of AURKA degrons, the contribution of APC/C-FZR1 in the timing of AURKA inactivation, identifying the physiological consequences …
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The Expanding Diversity of Plant U-box E3 Ubiquitin Ligases in Arabidopsis: Identifying AtPUB18 and AtPUB19 Function during Abiotic Stress Responses
… As part of these diverse cellular functions, ubiquitin-mediated proteolysis has emerged to be an important process involved in how plant signalling pathways can be regulated in response to such cues. Of the three enzymes involved in linking ubiquitin to protein targets, E3 ubiquitin ligases …
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Exploring genetic interactions with G-quadruplex structures
… of G4s by small molecules can perturb G4-mediated processes and initial studies suggest that this approach has chemotherapeutic potential. I therefore also aimed to identify cell genotypes sensitive to G4-ligand treatment that may offer further therapeutic opportunities. To address these …
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Enzyme Architecture and Flexibility Affect DNA Topoisomerase I Function
… checkpoint, processive DNA replication, or ubiquitin-mediated proteolysis. The core and C-terminal domains are connected by extended α-helices (linker domain), which position the active site Tyr within the catalytic pocket. The physical connection of the linker domain with the Top1 clamp as …
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Biochemical Context Drives Inhibitor Selectivity in Aurora A Kinase
… Aurora A, as this complex protects N-Myc from ubiquitin-mediated proteolysis. However, no current compounds can effectively dissociate this complex in cellular models, and further inhibitor development is hindered by a lack of complete structural detail of the complex. An understanding of the …
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Post-translational Regulation of Plant Fatty Acid Desaturases as Expressed in Saccharomyces cerevisiae
Differences have been shown in the steady-state accumulation and half-lives between Brassica FAD3 (BF3) and tung FAD3 (TF3) proteins expressed in yeast cells cultured at 30°C. TF3 has a greater steady-state accumulation and longer half-life than BF3. These differences are attributed to …
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The Role of Bcl-xL and EGFR in the Malignant Progression of Neurofibromatosis type 1
… of the NF1 gene, as in the neurofibromin-mediated EGFR expression, caused the high expression of Bcl-xL in MPNST cells. Because Bcl-xL is also one of the downstream proteins of the Ras/Erk/Sp1 pathway, I tested the effect of Erk1/2 in regulation of the neurofibromin-mediated Bcl-xL …