Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"ubiquitin-interacting motif"”.
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Investigating the role of DA1 in growth control.
… described in this thesis identify an active ubiquitin interacting motif (UIM) in the N-‐terminal region of DA1 and an ubiquitin-‐activated metallopeptidase in its C-‐terminal region. Further studies reveal that, in addition to being activated by the RING E3 ligases EOD1/BB and DA2, the DA1 …
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Design and Characterization of Chimeric Probes Specific to K48-K63-linked Heterotypic Ubiquitin Chains
<p>Ubiquitin signaling plays a central role in orchestrating cellular processes and regulating dynamic molecular interactions. Consequently, dissecting the mechanisms that govern diverse biological pathways relies heavily on our ability to interpret the complexity of ubiquitin modifications. A …
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Structural and Functional Characterization of the Endosome-associated Deubiquitinating Enzyme AMSH
… required for transport (ESCRT) machinery is a ubiquitin-dependent molecular mechanism made of up of four individual complexes: ESCRT-0, -I, -II, III, that is necessary for regulating the degradation of cell surface receptors directed towards the lysosome. Not only are the ESCRTs implicated in …