Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"ubiquitin proteasome system"”.
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PMI 5011 regulates the ubiquitin proteasome system in skeletal muscle
… a process that is primarily regulated by the ubiquitin-proteasome system. Studies have shown that an extensively characterized ethanol extract of Artemisia dracunculus L (Russian Tarragon), termed PMI 5011, enhances insulin signaling in human primary skeletal muscle cells and in a rodent model …
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Design and synthesis of molecular tools for the ubiquitin proteasome system
… 0.5% of the population living with dementia. The ubiquitin proteasome system (UPS), in particular the interaction between a mutant form of ubiquitin, Ubb+1, and the E2-conjugating enzyme E2-25K, has been identified as playing a possible pathophysiological role in the early and late stage …
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Age related memory loss and the role of the ubiquitin proteasome system
… as the accumulation of damaged proteins. The ubiquitin-proteasome system (UPS), responsible for breaking down damaged proteins, exhibits dysfunction in neurodegenerative disorders like Alzheimer's disease or dementia. While we acknowledge that proteasome function declines with age, its …
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An investigation into the role of the ubiquitin-proteasome system in plant defence
Ubiquitin is a highly conserved regulatory protein that is ubiquitously expressed in eukaryotes. The ubiquitin pathway appears to be more diversified in plants compared to the other organisms. In plants, the ubiquitin-26S proteasome pathway appears to be particularly involved in regulating plant …
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Non-proteolytic roles of the ubiquitin-proteasome system in memory formation across the lifespan
… Epigenetic modifications, such as histone monoubiquitination and ubiquitin signaling, have emerged as key players in these processes. While monoubiquitination of histone H2B is a well-established regulator of increased gene transcription in memory formation, the role of histone H2A …
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Sex-differences in proteasome-independent roles of the ubiquitin proteasome system in memory formation
… in protein degradation during fear memory is the ubiquitin-proteasome system (UPS), which utilizes the small protein ubiquitin to label proteins. Ubiquitin contains eight linkage sites that each lead to a unique outcome for the protein being labeled and a protein can gain one (monoubiquitination) …
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Investigating new roles of the ubiquitin proteasome system in cell death and innate immune signalling
… we explored the role of some regulators of the ubiquitination and proteasome systems in cell death and innate immune signalling pathways in macrophages. Initial studies focused on a form of regulated cell death termed necroptosis, a type of cell death mediated by the receptor-interacting protein …
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The Role of the Ubiquitin-Proteasome System in the Regulation of Nuclear Hormone Receptor-Dependent Transcription
… rekrutieren NHRs auch Komponenten des Ubiquitin-Proteasom-Systems an die Zielgene. Das Ubiquitin-Proteasom-System (UPS) ist das wichtigste intrazelluläre Proteinabbausystem und ist Ziel in der Krebstherapie (Bortezomib). Verschiedene Indizien sprechen für eine wesentliche Rolle des UPS …
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Mechanisms of Controlled Proteolysis during Drosophila Spermatogenesis: Coordinate Action of Apoptotic Caspases and the Ubiquitin-Proteasome System
… to be required for caspase activation in this system. We also isolated two members of a Cullin-3-based ubiquitin ligase complex, Cullin-3T and KLHL10. The mutations in cullin-3 were in a specialized intron that splices into a testis-specific isoform, the first characterization of a …
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Components of the Ubiquitin Proteasome System are Required for the Nonapoptotic Death of the C. Elegans Linker Cell
… Our work suggests that components of the ubiquitin proteasome system (UPS) act to promote linker cell death. We show that LET-70, an E2 ubiquitin-conjugating enzyme, is required cell-autonomously for linker cell death. LET-70 levels, as well as those of ubiquitin and some proteasome …
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Investigation of the ubiquitin-specific protease UBP41 and of the lysosomal cysteine proteases cathepsin-L and cathepsin-B as potential mediators of proapoptotic signalling
… this thesis. The first project characterizes the ubiquitin-specific protease UBP41 as a protein which upon overexpression causes apoptosis induction in several mammalian cancer cell lines. The second project investigates a possible involvement of the lysosomal cysteine proteases cathepsin-L and …
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Persistent “hijacking” of brain proteasomes in HIV-associated dementia
… virus-1 (HIV) infection of the central nervous system results in a syndrome of neuropsychological impairment, motor deficits, and behavioral changes diagnosed as HIV-associated dementia. Findings of increased ubiquitin-stained deposits and high molecular weight ubiquitin-protein conjugates in …
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Regulation of Protein Degradation In The Heart By Amp-Activated Protein Kinase
<p>The degradation of proteins by the ubiquitin proteasome system is essential for cellular homeostasis in the heart. An important regulator of metabolic homeostasis is AMP-activated protein kinase (AMPK). During nutrient deprivation, AMPK is activated and intracellular proteolysis is enhanced …
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Regulation of Protein Degradation In The Heart By Amp-Activated Protein Kinase
<p>The degradation of proteins by the ubiquitin proteasome system is essential for cellular homeostasis in the heart. An important regulator of metabolic homeostasis is AMP-activated protein kinase (AMPK). During nutrient deprivation, AMPK is activated and intracellular proteolysis is enhanced …
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Induction of Caspase-Dependent Death By Proteasome Targeted Therapy In Glioblastoma
… of only 14 months with current treatment. The proteasome inhibitor bortezomib (BTZ) shows efficacy in cancers like myeloma, but its clinical utility in other cancer types has been more limited. Newer proteasome inhibitors such as marizomib (MRZ) have unique inhibitory and death inducing …
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Hypertrophic Cardiomyopathy: A Review of Clinical and Molecular Characteristics and Effects and A Clinical Case Study
… of such mutant forms on the quality control ubiquitin-proteasome system (UPS) contribute to cardiac dysfunction. The E334K mutant cMyBP-C has been shown to destabilize its protein and lead to the impairment of the UPS, resulting in the clinical arrhythmias and cardiac dysfunction observed in …
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The study of sonic hedgehog signaling pathway in the development of lysosomal acid phosphatase (Acp2) mutant mice cerebellar granule cells
… which was accompanied by an increase in proteasome activity, suggesting that the significant reduction of granule cells in nax cerebellum is potentially due to the dysregulation of N-Myc via the abnormal ubiquitin-proteasome system activity.
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Molecular function and regulation of the Bax-associating protein MOAP-1
… protein due to constitutive degradation by the ubiquitin-proteasome system. MOAP-1 is rapidly up-regulated by multiple apoptotic stimuli through inhibition of its poly-ubiquitination process. Elevation of MOAP-1 levels sensitizes cells to apoptotic stimuli, whereas, cells with stable expression …
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Development of Protein Degraders Inspired by Chemical Modifications
… that the Dha-based degrader operates through the ubiquitin-proteasome system by recruiting a Cullin-RING E3 ligase. Lastly, transferability studies showed that the incorporation of the Dha handle into phosphodiesterase type-5 (PDE5) and androgen receptor (AR) binders also promoted target …
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Studies of the UNC-45A Molecular Chaperone Expression in Human Cancer
… in human breast cells. More importantly, the ubiquitin-proteasome system degraded endogenous UNC-45A and the 15 amino acid sequence unique to UNC-45A 944 protein mediated rapid turnover in mammalian cells.
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