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Showing 1 to 20 of 253 for “"ubiquitin ligase"”.
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Characterization of SCF Ubiquitin-Ligase Subunits in Arabidopsis
… in the formation of the SCF-class of E3-ubiquitin ligase complexes. One such gene family encodes the Skp1-like class of polypeptide subunits, where 21 genes have been identified and are known to be expressed in Arabidopsis. The complexity of this family of Arabidopsis Skp1-like--or ASK …
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Regulation of Apoptosis by XIAP Ubiquitin- Ligase Activity
… IAPs contain RING domains that function as E3 ubiquitin-ligases to regulate the abundance of IAPs themselves and their binding partners by engaging the ubiquitin system. The precise physiological function of individual mammalian IAPs and their role as E3- ubiquitin ligases in situ remain …
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Characterization of The Ubiquitin Ligase, Ube4B, In Endocytic Trafficking
… extinguishes their signaling activity.</p> <p>Ubiquitination is a post-translational modification that underlies some aspects of membrane protein trafficking. Ubiquitin modification allows EGFR recognition by endosomal protein complexes that mediate protein inclusion into MVB vesicles from …
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Insights into the regulation of the CRL4D̳T̳L̳ ubiquitin ligase
… duplicate their genome and divide into two. Ubiquitin-mediated degradation of key cell cycle regulators ensures that the cell cycle phases progress in a unidirectional and orderly manner. Cullin E3 ubiquitin ligases (CRLS) comprise a large family of multi-subunit complexes that selectively …
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바이러스 감염시 미토콘드리아 E3 ubiquitin ligase 인 MARCH5의 새로운 생체 기능
… central role in preserving cellular homeostasis. Ubiquitin proteasome system (UPS) on the mitochondria is one of quality control systems that works as a first line barrier against aggregated or misfolded proteins. In this study, I investigated functional role of mitochondrial E3 ligase, MARCH5, …
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The Role of HOIL 1 Ubiquitin Ligase Activity in MDA5 Antiviral Signaling
… Previous work had identified that the E3 ubiquitin ligase, HOIL1, is essential for the induction of type 1 interferons in response to viral infections primarily sensed by MDA5 but is dispensable for RIG-I mediated interferon induction. However, these findings were confounded by the role of …
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Functional Interactions Between Par-1b Protein Kinase and RNF41 E3 Ubiquitin Ligase
… proteins. Nrdp1/RNF41, a RING finger E3 ligase was identified in their screen along with 14-3-3 and aPKC. I found that Par-1b binds to RNF41 and I identified RNF41 as a novel cell polarity determinant. My work demonstrated that phosphorylation of RNF41 on S254 by Par-1b is necessary for …
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Regulation of Substrate Degradation and Cancer Metabolism by the Fbw7 Ubiquitin Ligase
… is the substrate binding subunit of an SCF E3 ubiquitin ligase, which catalyzes the polyubiquitylation of substrates, initiating their recognition and degradation by the proteasome. The affinity of Fbw7 for its substrates is substantially increased following substrate phosphorylation at …
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Biochemical Characterization of IpaH E3 Ubiquitin Ligase Effector Proteins and Their Host Substrates
… including Salmonella and Yersinia secreted E3 ubiquitin ligases into the host cell cytoplasm via the Type III secretion system (T3SS) apparatus. The invasion plasmid antigen Hs (IpaHs) are a novel family of bacterial E3 ubiquitin ligases that are secreted by Shigella, Salmonella, and Yersinia. …
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The Ubiquitin Ligase Ube4B Is Required For Efficient Epidermal Growth Factor Receptor Degradation
… sorting complexes are believed to recognize ubiquitin as sorting signals. However, the link between MVB sorting machinery and the ubiquitination machinery is not known. Recently, Hrs was shown to recruit and bind an E3 ubiquitin ligase, UBE4B, to endosomes. In an assay that is able to measure …
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Defining a Novel Role for the E3 Ubiquitin Ligase Wwp1 in Cardiac Arrhythmogenesis
… lab is interested in examining the role of the ubiquitin ligase Wwp1 in regulating Cx expression during normal postnatal cardiac development as well as in gap junction remodeling associated with cardiac dysfunction. Thus, we created a mouse model which completely lacks Wwp1 activity (Wwp1-/-) as …
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Developing Constrained p27 Peptides to Target the Oncogenic E3 Ubiquitin Ligase SCF-Skp2
The ubiquitin-proteasome system (UPS) maintains homeostatic levels of proteins in normal cells and controls the levels of oncogenes and tumour suppressors by tagging proteins with ubiquitin for proteasomal degradation. The UPS is regulated by sequential action of three enzymes: E1 – ubiquitin …
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Investigation of the E3 ubiquitin ligase UBR5; a novel regulator of Hh gene expression
The Hedgehog (Hh) signalling pathway is essential for embryogenesis and regulating cellular homeostasis in the adult, however much remains unknown about the molecular mechanisms that control ligand expression. In 2002, Lee et al. demonstrated that conditional mutation of the Drosophila hyperplastic …
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The role of E3 ubiquitin ligase CBLB in mediating innate immunity to pulmonary infections
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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Regulation of microRNA degradation in Caenorhabditis elegans via the E3 ubiquitin ligase EBAX-1
… in AGO, leading to the recruitment of an E3 ubiquitin ligase complex containing the substrate receptor ZSWIM8. The subsequent polyubiquitination and proteolysis of AGO liberates the miRNA, rendering it vulnerable to nucleases. TDMD underlies the instability of many miRNAs in diverse cell …
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Nur77 Prevents Excessive Osteoclastogenesis by Inducing Ubiquitin Ligase Cbl-b to Mediate NFATc1 Self-Limitation
… in turn, Nur77 transcriptionally up-regulates E3 ubiquitin ligase Cbl-b, which triggers NFATc1 protein degradation. These findings not only identify Nur77 as a key player in osteoprotection and a new therapeutic target for bone diseases, but also elucidate a previously unrecognized …
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Small-molecule approaches to interrogate the druggability of the VHL E3 Cullin RING Ubiquitin Ligase
… more drug discovery programs to target PPIs. E3 ubiquitin ligases are attractive targets within the ubiquitin proteasome system, which function via PPIs. The von Hippel-Lindau protein (VHL) forms part of an E3 ubiquitin ligase for which the main biological function is to recognize and …
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Characterizing the Role of the E3 Ubiquitin Ligase Subunit MAEA in DNA Repair and Replication
… for the first time the role of the CTLH E3 ubiquitin ligase complex catalytic subunit MAEA in the DNA damage response. I identified MAEA through focused CRISPR- Cas9 screens using the chemotherapeutic agents camptothecin and etoposide. My subsequent investigations demonstrate that MAEA loss …
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