Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"ubiquitin; proteins"”.
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Structure function analysis of the deubiquitylating enzyme Fam
The ubiquitin pathway is a highly conserved post-translational modification system best characterised for its roles in protein degradation and intracellular trafficking and is involved in a diverse spectrum of cellular processes. Ubiquitylation is opposed by deubiquitylating enzymes (Dubs), and the …
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Protein quality and distribution determines anabolic signaling, cellular energetics, and body composition
… turnover is a continuous process in which proteins are degraded, and replaced by newly synthesized proteins. Muscle growth occurs when protein synthesis exceeds protein degradation. Regulation of protein synthesis is complex, with multiple signals influencing this process. The mammalian …
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Probing static disorder in protein unfolding and chemical reactions by single-molecule force spectroscopy
… we study the nonexponential kinetics of single ubiquitin proteins unfolding under constant forces. We find that the measured variance in the barrier heights has a quadratic dependence on force. Our study illustrates a novel adaptation of the classical Arrhenius equation that accounts for the …
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Utilizing Proteomic Techniques to Discover Host Protein Interactions with the E1 Glycoprotein of Venezuelan Equine Encephalitis Virus (VEEV) for Anti-Viral Discovery
… matches (PSMs) revealed a number of chaperone proteins and ubiquitin proteins as top interactors of VEEV E1. These results effectively revealed a number of previously unknown alphavirus interactions that can be targeted by antivirals and explored further for implications in viral replication. …
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Mechanisms and regulation of dsDNA break repair in the Sulfolobus genus of thermophilic archaea
… chromatid to replace any lost information. Key proteins involved in maintaining genomic stability this way are conserved in all domains of life. One such component is the Mre11/Rad50 complex that is involved in the initial recognition of damage and recruitment of subsequent repair factors. …