Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"tyrosines"”.
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FTIR study of carboxylic acids and tyrosines in bacteriorhodopsin
… acids in bR were monitored by 13C labeling. Tyrosines were monitored by both 2H and nitrate substitution. Some of the amino acid band regions were decomposed by curve fitting. Alteration of absorption bands among individual bR states were found for aspartic acids and tyrosines, but were not …
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A mechanism of activation of c-MET receptor tyrosine kinase
… and is autophosphorylated on specific tyrosines on its cytoplasmic domain. The phosphorylated tyrosines in specific sub-domains of c-MET cytoplasmic region perform specific functions including increase in catalytic activity and recruitment of effector molecules. Classically, it has been …
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Probing Isoforms of the Prion Protein through Tyrosine Nitration
… are reported. Two conserved tyrosine residues (tyrosines 149 and 150) are not labeled by either reagent in the normal cellular form of the prion protein but these residues become reactive after the protein has been converted to one of two aggregated isoforms. Another difference observed is that …
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Probing Isoforms of the Prion Protein through Tyrosine Nitration
… are reported. Two conserved tyrosine residues (tyrosines 149 and 150) are not labeled by either reagent in the normal cellular form of the prion protein but these residues become reactive after the protein has been converted to one of two aggregated isoforms. Another difference observed is that …
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Regulation of Protein Kinases (Syk and PKC zeta) in platelets
… the activation-dependent phosphorylation of tyrosines 753/759 on PLC gamma2 and phosphorylation of tyrosine 191 on the transmembrane scaffold protein LAT, were inhibited (p<0.05). However, the phosphorylation of the activation loop tyrosines 525/526 on Syk and of the tyrosine 145 on …
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Comparison of CLEC-2 and GPVI signaling in platelets: the role of adaptor proteins
… (Yxx(L/I)x\(_{6-12}\)Yxx(L/I)). These two tyrosines provide a docking site for the tandem-SH2 domains of Syk. In this thesis I show that CLEC-2 signalling through Syk is mediated by phosphorylation of the CLEC-2 YxxL sequence, receptor dimerisation and cross-linking by the Syk SH2 domains. …
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Role of basic and hydrophobic residues in the poliovirus polymerase elongation complex and the structure of a coxsackievirus polymerase elongation complex
… the role of that several arginines, lysines, and tyrosines play in the PV polymerase, we assessed whether mutations to these residues affect initiation, elongation, or stability of the EC. The data indicates the basic residues within the fingers domain of the PV polymerase have a major role in …
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Mechanistic Characterization of RTK Signaling Networks Using Phosphoproteomic Approaches
… the network effects of loss of phosphorylatable tyrosines that the protein of interest seemingly depends on, allows for an unbiased mechanistic characterization of the signaling network. When implemented with various computational tools, these data can provide a predictive model that can inform …
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Insulin-like growth factor receptor activity in cancer biology & therapy responses
… and in particular, by a motif that encompasses tyrosines 1250 and 1251 flanked by serines 1248 and 1252 (1248- SFYYS-1252). Mutation of Y1250/1251 greatly reduces IGF-1-promoted cell migration, interaction with the scaffolding protein RACK1 in the context Integrin signalling, and IGF- 1R kinase …
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Structure determination of proteins and peptides in solution: simulation, chirality and NMR studies
… presence of prolines, histidines and especially tyrosines, which form a hydrogen bond network in the hexarepeat region, only possible in the avian protein, and thus probably hampering the aggregation.
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Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation
… 2 (JAK2), which phosphorylates cytoplasmic tyrosines of the EpoR. Signaling proteins bind these phosphotyrosines through SH2 domains, leading to the survival and proliferation of erythroid progenitor cells and the differentiation of these progenitors into mature erythrocytes. Therefore, EpoR …
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Identification of EWS-FLI1 Regions Necessary for Ewing Sarcoma Proliferation
… 1-5 of the N-terminus of EF. Mutation of only 3 tyrosines to serine within the minimal construct was sufficient to prevent proliferation in Ewing cell lines.
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Phospho-regulation and metastatic potential of Murine Double Minute 2
… of cellular processes, phosphorylates Mdm2 on tyrosines 281 and 302. This phosphorylation event increases the half-life and neddylating activity of Mdm2 resulting in a neddylation dependent reduction of p53 transcriptional activity. Mdm2 also has many p53-independent cellular functions that are …
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Functional relationships among lck kinase and the lat and grb2 adaptors in the intracellular signaling cascade of the tcr/cd3 complex: implications in thymic development and lymphocyte activation
… of phosphorylation with respect to the other LAT tyrosines. This mechanism could constitute an essential step in the kinetic proofreading model for ligand discrimination. To elucidate the biological function of this glycine in vivo, thymic and peripheral T lymphocyte populations from LATG135D …
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Quantitative mass spectrometry analysis of the early signaling dynamics of the epidermal growth factor receptor
… of the network with clinically relevant tyrosines kinase inhibitors reveals temporally distinct effects of inhibitors in early signaling. Combination of broad kinase and phosphatase inhibition produces unusual results that raise further questions of EGFR signaling. Together, the tools …
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The development of the rumen fluke, Calicophoron daubneyi, within the mammalian host
… analysis revealed that a number of conserved tyrosines known to be crosslinked in other species have been replaced by cysteines in C. daubneyi eggshell precursor proteins suggesting that rumen fluke use different crosslinking chemistry (potentially disulphide linkages) during the final stages …
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Molecular Mechanisms Of Pressure-Stimulated Cancer Cell Signaling
… data illustrate that paxillin phosphorylation at tyrosines 31 and 118 is necessary for pressure stimulated adhesion, but tyrosine 81 phosphorylation is not. The phosphorylation events at tyrosine 31 and 118 form a docking site for the adaptor molecule Crk, which has a binding site for the highly …
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Biosynthesis of Caldariellaquinone in Sulfolobus acidocaldarius
… of methods. By growing cells with a series of tyrosines labeled with deuterium or ¹³C and measuring the extent and position at which label was incorporated into the CQ by mass spectrometry, it was concluded that the benzo[b]thiophen-4,7-quinone ring of CQ is derived as an intact unit from all …
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Synthesis of Novel Amino Acids and Peptidomimetics as Tools for Drug Discovery
… 4-heteroarylphenylalanines and O-arylated tyrosines) was carried out. The preparation of a series of Boc and methyl ester protected substituted biphenylalanines (3a-j) involved the palladium-catalysed Suzuki-Miyaura coupling of a tyrosine triflate intermediate 8 with various organoboron …
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Studies on the structure, function and mechanisms of the cbb3 type cytochrome c oxidase from Vibrio cholerae and the cytochrome bo3 ubiquinol oxidase from Escherichia coli
… which demonstrated the radicals originates on tyrosines. Further analysis of the signal splitting pattern revealed that the radical is on Y173 in the case of WT and Y288H, while in the case of Y173F radical is likely on Y288. Together with stop flow data, we were able to conclude that for H2O2 …
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