Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 99 for “"tyrosine phosphorylation"”.
-
The Functional Analysis of A Major Tyrosine Phosphorylation Site On Actin
… In this work, I investigate the role of actin phosphorylation at tyrosine 53 (pY53), one of the most frequently detected actin PTMs, through identifying interaction partners, or ‘readers’, for this modification. Using an SH2 (Src Homology 2) protein domain array, we identify N-terminal SH2 …
-
Tyrosine phosphorylation and cytoskeletal tension regulate the release of fibroblast adhesions
… the periphery of the cell. Interestingly, phosphotyrosine staining as well as nascent, intracellular integrin precedes the recruitment of focal adhesion constituents into the trabecular network. The ATP-stimulated focal adhesion breakdown appears to operate through two mechanisms. First ATP …
-
Calcium- and tyrosine phosphorylation-dependent mechanisms of amyloid precursor protein processing
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
-
The Role of Tyrosine Phosphorylation In The Functions of The Tumor Suppressor Gprc5A
… by posttranslational modification(s) such as phosphorylation. It is well established that Serine/Threonine phosphorylation of G protein coupled receptors leads to their desensitization and in a few cases Tyrosine phosphorylation of GPCRs has been linked to internalization. Others reported that …
-
Tyrosine Phosphorylation of Villin: Effects on Actin Dynamics, Cell Morphology and Cell Migration
… cell migration. We further demonstrate that tyrosine phosphorylation of villin by c-src is required for villin-induced cell migration. Previously, we identified four tyrosine phosphorylation sites in the amino-terminal domain of villin. I further identified six new sites in the …
-
Protein Tyrosine Phosphorylation in Haematopoietic Cancers and the Functional Significance of Phospho- Lyn SH2 Domain
Protein-tyrosine phosphorylation (pY) is a minor but important protein post-translational modification that modulates a wide range of cellular functions and is involved in cancer. Dysregulation of tyrosine kinases (TKs) and protein-tyrosine phosphatases (PTPs) have been observed in multiple myeloma …
-
MHC Class I Tyrosine Phosphorylation Site Y320 Augments CD8+ T Cell Priming, Effector Function, and Memory Response
… molecules contains a single, highly conserved tyrosine residue (Y320). In previous work, we found that mice expressing a Y320F-mutated form of H-2K<sup>b</sup> had reduced capacity to generate K<sup>b</sup>-restricted cytotoxic T lymphocyte (CTL) responses following viral infection, due (at …
-
Bridging the gap between protein-tyrosine phosphorylation networks, metabolism and physiology in liver-specific PTP1b deletion mice
… risk. Studies of liver-specific protein-tyrosine phosphatase lb (PTPlb) deletion mice (L-PTPlb-/-) suggests that hepatic PTPlb inhibition would mitigate metabolic syndrome progression through amelioration of hepatic insulin resistance, endoplasmic reticulum stress, and whole-body lipid …
-
The localization of UCH-L1(Ubiquitin C-terminaHydrolase-L1) in lipid rafts of neuronal cell
… dimerization, glycosylation, serine/threonine phosphorylation or tyrosine-phosphorylation play arolein the localization of UCH-L1 into lipid rafts. This study demonstrated that UCH-L1 associated with lipid rafts through tyrosine phosphorylation. But, the tyrosine phosphorylation of UCH-L1 might …
-
Regulation of Exocytosis by Syntaxin 4-Munc18c Complexes
… that Syn4-Munc18c complexes are regulated by tyrosine phosphorylation of Munc18c at Y219 in beta cells. Munc18c tyrosine phosphorylation disrupts Syn4-Munc18c complexes, which leads to an increase in Munc18c associating with the double C2 domain protein Doc2β. Disruption of Syn4-Munc18c upon …
-
Molecular mechanisms involved in the regulation of beta-cell viability by Signal Regulatory Protein-Alpha (SIRPα)
… study, the aim was to explore the importance of tyrosine phosphorylation of SIRPα in maintaining the interaction with HDAC6 by replacing the cytoplasmic tyrosine residues with phenylalanine to block the phosphorylation events. Several molecular and cellular approaches were employed, including …
-
The interconnected KIT receptor and Microphthalmia-associated transcription factor axis in melanoma
… events in melanocytes. The KIT receptor tyrosine kinase and the Microphthalmia-associated transcription factor (MITF) are two essential components that are required for the normal physiology of melanocyte development and function. Consequently, aberrant activities of these factors are …
-
Insulin Receptor Substrate-1 Serine Phosphorylation by a Novel Phosphatidylinositol-3'-Kinase-Associated Serine Kinase Regulates Insulin and Interferon Receptor Signaling
… importantly, PAS kinase mediated IRS-1 serine phosphorylation reduced subsequent tyrosine phosphorylation of IRS-1 by insulin receptors (IRs). Finally, under hyperinsulinernic conditions, IRS-1 serine phosphorylation by PAS kinase can reduce IFNalpha mediated IRS-1 tyrosine phosphorylation. …
-
Translational phosphoproteomics methods to identify biomarkers and novel therapeutic targets
Phosphorylation plays a fundamental role in cellular processes, and it is commonly dysregulated in cancer. Characterization of phosphorylation mediated signaling networks in tumors can inform therapeutic interventions. Additionally, analysis of phosphoproteome in response to drug candidates can …
-
Biochemical and physiological changes in bovine sperm during extended incubation under aerobic and anaerobic conditions
… substrate is available. Changes in protein tyrosine phosphorylation, viability and motility were studied as a function of extended storage of bovine sperm in vitro at ambient temperature (18-20°C). Over a period of 8 days of storage at ambient temperature there was a time-dependent decline …
-
Characterization of IphP from Nostoc commune UTEX 584 and a Dual Specificity Protein Phosphatase from Anabaena PCC 7120
Protein phosphorylation is utilized universally as a mechanism of signal transduction. However, the use of tyrosine phosphorylation by bacteria has been a matter of dispute. Conventional wisdom dictated that "prokaryotic phosphorylation" was typified by phosphorylation of histidine and aspartate …
-
Probing the assembly of the <em>Bacillus subtilis</em> flagellum and its role in signal transduction.
… extracellular polymeric matrix. <br/> Bacterial tyrosine phosphorylation is required for <em>B. subtilis</em> biofilm formation and has been suggested to also play a role in regulating the putative motility protein, YvyG. This led to the hypothesis that tyrosine phosphorylation might play a role …
-
A Role for RAS in V-CRK Transformation
… oncogene product, while possessing no intrinsic tyrosine kinase activity, causes an elevation in levels of cellular phosphotyrosine as it transforms chicken embryo fibroblasts (CEF). Because of this similarity to v-Src transformation and EGF receptor (EGFR) stimulation, signalling pathways that …
-
Mechanisms of Eph/ephrin mediated cell-cell communication
… ligand ‘reverse signaling’ is the regulated tyrosine phosphorylation of the cytoplasmic domain, initiating docking sites for downstream signaling adaptors. Moreover, ephrinB ligands can signal by interactions with various PDZ-domain containing proteins. Using a broad range of in vitro assays …
-
Pyp3 Involvement in Mitotic Control and Cell Growth in Fission Yeast
In fission yeast, Schizosaccharomyces pombe, tyrosine dephosphorylation of p34cdc2 is required for mitotic initiation and this reversible tyrosine phosphorylation plays a crucial role in the regulation of the cell cycle. The kinases wee1+, mik1+ and the phosphatases cdc25+, pyp3+ play opposite …
Page 1 of 5