Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 71 for “"tyrosine phosphatase"”.
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Regulation of cell motility by Shp-2 tyrosine phosphatase
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Investigations into the chemistry of protein tyrosine phosphatase redox regulation
… reversible phosphorylation of specific protein tyrosine residues. This reversible phosphorylation serves as a biochemical "rheostat" that alters a protein's functional properties and leads to propagation of the signal. The phosphorylation status of these tyrosine residues, thus transmission of …
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Signalling mechanisms of the tyrosine phosphatase SHP2 upstream of Ras
… SHP2 is a cysteine-based non-receptor protein tyrosine phosphatase (PTP). It is susceptible to redox regulation; although canonically it is thought to be inactivated by oxidation, our lab has identified the capacity for specific redox-regulated interactions with PTPs, at least in vitro. To …
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Small Phosphomonoesters as Probes of Protein-Tyrosine Phosphatase Active Sites
… differentiating between two families of protein phosphatases: the protein-tyrosine phosphatases [PTPs] and the dual-specificity protein phosphatases [DSPs]. Three PTPs, PTP-1B, Tc-PTPa, and PTP-H1, and three DSPs, Cdc-14, VHR, and IphP, were challenged in vitro with alpha-naphthyl phosphate and …
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Characterization of the molecular environment of the protein tyrosine phosphatase PTP-BL
Contains fulltext : 18735.pdf (Publisher’s version ) (Open Access)
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Targeting the protein tyrosine phosphatase, SHP2, and PI3K in FLT3-ITD+ leukemia
Internal tandem duplications in the fms-like tyrosine kinase receptor (FLT3-ITDs) cause constitutive activation of the receptor and confer a poor prognosis in acute myeloid leukemia (AML). We hypothesized that Shp2 interacts with FLT3-ITD via protein complexes at tyrosine (Y) 768, 955, and/or 969 …
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Protein Tyrosine Phosphatase Receptor Type S (PTPRS) Regulates Hematopoietic Stem Cell Self-Renewal
… are regulated by signaling through protein tyrosine kinases (PTK) such as c-kit, Flt-3 and Tie2. PTKs work in concert with receptor protein tyrosine phosphatases (PTPs) to maintain cellular equilibrium. The functions of PTPs in counterbalancing PTK signaling in HSCs however remain …
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The Role Of Protein Tyrosine Phosphatase 1b In The Central Regulation Of Energy Homeostasis
Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed tyrosine phosphatase implicated in the central control of energy homeostasis via negative regulation of leptin signaling. Mice with central nervous system (CNS)-specific PTP1B deficiency demonstrate clear metabolic improvements, …
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Synthesis of exo-affinity labeling agents of protein tyrosine phosphatase non-receptor type 1
… OF MISSOURI AT AUTHOR'S REQUEST.] Protein-tyrosine phosphatase 1B (PTP1B) is a negative regulator in the insulin signaling cascade. A lot of research has focused on inhibiting PTP1B but with no success. Only one drug is currently in phase II clinical trials. We have developed a synthetic …
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An investigation of the structure and function of the receptor-type protein tyrosine phosphatase CD148
CD148 is an R3 receptor-type protein tyrosine phosphatase (RPTP) found on platelet surfaces, where it has a vital dual role in regulating platelet signalling and thrombosis. Inhibition of CD148 has been suggested as a novel anti-thrombotic strategy. Loss-of-function polymorphisms located in the …
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The receptor tyrosine phosphatase Ptp69D and the receptor tyrosine kinase Pvr in Drosophila nervous system development
… migration in Drosophila. Ptp69D is a receptor tyrosine phosphatase required for axon guidance in the developing embryo and for layer-specific axon targeting in the developing visual system. Using a dominant-negative form of Ptp69D, I have identified several genes with which Ptp69D genetically …
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The Regulation of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP-2) in Brain Microglia
SHP-2, a member of protein tyrosine phosphatases (PTPs), plays a role on the regulation of several signaling pathway such as NF-kB, MAP kinase, JAK-STAT, and PI3 kinase. However, the roles of SHP-2 in brain microglia activation are largely unknown. Here, I determined the regulation of SHP-2 on …
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Rôles de la protéine tyrosine phosphatase SHP-2 dans l'inflammation intestinale et le cancer colorectal associé à la colite
SHP-2 est une tyrosine phosphatase impliquée dans la signalisation intracellulaire déclenchée par des facteurs de croissance, des cytokines pro-inflammatoires et des produits bactériens. Bien que cette phosphatase soit exprimée de manière ubiquiste et donc dans l’épithélium intestinal, son rôle …
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The diverse branches of PTPRR protein tyrosine phosphatase function. New insights in cell differentiation, neuronal signalling and mouse behaviour
Contains fulltext : 161370.pdf (Publisher’s version ) (Open Access)
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Identification of a Low Molecular Weight Protein Tyrosine Phosphatase and Its Potential Physiological Substrates in Synechocystis sp. PCC 6803
… with known low molecular weight protein tyrosine phosphatases (PTPs). To determine the gross functional properties of this hypothetical protein, open reading frame slr0328 was cloned, and its predicted protein product was expressed in E. coli. The recombinant protein, SynPTP, was purified …
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Non-autonomous regulation of bone mass accrual and the role of T-cell protein tyrosine phosphatase in the bone regulation of insulin sensitivity
… cascade is negatively regulated by ESP, a tyrosine phosphatase dephosphorylating the insulin receptor. is one of many tyrosine phosphatases expressed in osteoblasts, and this observation suggests that other protein tyrosine phosphatases may contribute to the attenuation of insulin receptor …
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